Systemic vasculitis in myelodysplastic syndromes

Detalhes bibliográficos
Autor(a) principal: Oostvogels, Rimke
Data de Publicação: 2012
Outros Autores: Petersen, Elijah Joel, Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP], Abrahams, Alferso C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://www.njmonline.nl/getpdf.php?id=1148
http://repositorio.unifesp.br/handle/11600/45006
Resumo: The development of immunological abnormalities in various neoplasms is a rather common phenomenon. The prevalence of life-threatening systemic vasculitis in malignancy, however, is much lower. Nonetheless we found an unexpected frequency of several autoimmune manifestations, including systemic vasculitis, in certain myelodysplastic syndromes.We illustrate this finding with the case of a 43-year-old man with signs of polyarteritis nodosa-like systemic vasculitis during progression of chronic myelomonocytic leukaemia. Subsequently, we review the literature on the combination of myelodysplastic syndromes and systemic vasculitis and discuss the prognostic consequences, considerations for treatment and possible pathophysiological mechanisms.
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spelling Systemic vasculitis in myelodysplastic syndromesChronic myelomonocytic leukaemiamyelodysplastic syndromespolyarteritis nodosavasculitisThe development of immunological abnormalities in various neoplasms is a rather common phenomenon. The prevalence of life-threatening systemic vasculitis in malignancy, however, is much lower. Nonetheless we found an unexpected frequency of several autoimmune manifestations, including systemic vasculitis, in certain myelodysplastic syndromes.We illustrate this finding with the case of a 43-year-old man with signs of polyarteritis nodosa-like systemic vasculitis during progression of chronic myelomonocytic leukaemia. Subsequently, we review the literature on the combination of myelodysplastic syndromes and systemic vasculitis and discuss the prognostic consequences, considerations for treatment and possible pathophysiological mechanisms.Univ Med Ctr Utrecht, Dept Haematol, Utrecht, NetherlandsUniv Fed Sao Paulo, Dept Haematol, Sao Paulo, BrazilUniv Med Ctr Utrecht, Dept Hypertens & Nephrol, Utrecht, NetherlandsUniv Fed Sao Paulo, Dept Haematol, Sao Paulo, BrazilWeb of ScienceVan Zuiden CommunicationsUniv Med Ctr UtrechtUniversidade Federal de São Paulo (UNIFESP)Oostvogels, RimkePetersen, Elijah JoelChauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]Abrahams, Alferso C.2018-06-18T11:15:18Z2018-06-18T11:15:18Z2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion63-68http://www.njmonline.nl/getpdf.php?id=1148Netherlands Journal Of Medicine. Alphen Aan De Rijn: Van Zuiden Communications, v. 70, n. 2, p. 63-68, 2012.0300-2977http://repositorio.unifesp.br/handle/11600/45006WOS:000308204600003engNetherlands Journal Of Medicineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:57:30Zoai:repositorio.unifesp.br/:11600/45006Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:57:30Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Systemic vasculitis in myelodysplastic syndromes
title Systemic vasculitis in myelodysplastic syndromes
spellingShingle Systemic vasculitis in myelodysplastic syndromes
Oostvogels, Rimke
Chronic myelomonocytic leukaemia
myelodysplastic syndromes
polyarteritis nodosa
vasculitis
title_short Systemic vasculitis in myelodysplastic syndromes
title_full Systemic vasculitis in myelodysplastic syndromes
title_fullStr Systemic vasculitis in myelodysplastic syndromes
title_full_unstemmed Systemic vasculitis in myelodysplastic syndromes
title_sort Systemic vasculitis in myelodysplastic syndromes
author Oostvogels, Rimke
author_facet Oostvogels, Rimke
Petersen, Elijah Joel
Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
Abrahams, Alferso C.
author_role author
author2 Petersen, Elijah Joel
Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
Abrahams, Alferso C.
author2_role author
author
author
dc.contributor.none.fl_str_mv Univ Med Ctr Utrecht
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Oostvogels, Rimke
Petersen, Elijah Joel
Chauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
Abrahams, Alferso C.
dc.subject.por.fl_str_mv Chronic myelomonocytic leukaemia
myelodysplastic syndromes
polyarteritis nodosa
vasculitis
topic Chronic myelomonocytic leukaemia
myelodysplastic syndromes
polyarteritis nodosa
vasculitis
description The development of immunological abnormalities in various neoplasms is a rather common phenomenon. The prevalence of life-threatening systemic vasculitis in malignancy, however, is much lower. Nonetheless we found an unexpected frequency of several autoimmune manifestations, including systemic vasculitis, in certain myelodysplastic syndromes.We illustrate this finding with the case of a 43-year-old man with signs of polyarteritis nodosa-like systemic vasculitis during progression of chronic myelomonocytic leukaemia. Subsequently, we review the literature on the combination of myelodysplastic syndromes and systemic vasculitis and discuss the prognostic consequences, considerations for treatment and possible pathophysiological mechanisms.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
2018-06-18T11:15:18Z
2018-06-18T11:15:18Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.njmonline.nl/getpdf.php?id=1148
Netherlands Journal Of Medicine. Alphen Aan De Rijn: Van Zuiden Communications, v. 70, n. 2, p. 63-68, 2012.
0300-2977
http://repositorio.unifesp.br/handle/11600/45006
WOS:000308204600003
url http://www.njmonline.nl/getpdf.php?id=1148
http://repositorio.unifesp.br/handle/11600/45006
identifier_str_mv Netherlands Journal Of Medicine. Alphen Aan De Rijn: Van Zuiden Communications, v. 70, n. 2, p. 63-68, 2012.
0300-2977
WOS:000308204600003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Netherlands Journal Of Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 63-68
dc.publisher.none.fl_str_mv Van Zuiden Communications
publisher.none.fl_str_mv Van Zuiden Communications
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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