Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://doi.org/10.1007/s40257-015-0164-2 https://repositorio.unifesp.br/handle/11600/58500 |
Resumo: | Background Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning the best treatment method. Objective We aimed to systematically review and meta-analyze published data comparing the efficacy and adverse effects of monochromatic excimer lamps versus excimer laser and narrowband ultraviolet B (NB-UVB) in treating vitiligo. Methods A systematic search of PubMed, EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), and clinical trials registries identified randomized controlled trials that included vitiligo patients, regardless of age, sex, or study language. We evaluated studies comparing excimer lamps with excimer laser or NB-UVB phototherapy. Results The review included six studies (411 patients, 764 lesions). No study found significantly different efficacy between excimer lamps and excimer laser using the outcomes of >= 50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84-1.11] and >= 75 % repigmentation (RR = 0.96, 95 % CI 0.71-1.30). Likewise, no study found significant differences between excimer lamps and NB-UVB (RR = 1.14, 95 % CI 0.88-1.48 for >= 50 % repigmentation; RR = 1.81, 95 % CI 0.11-29.52 for >= 75 % repigmentation). Adverse effects were mild, including pruritus, burning sensation, and dryness, none of which interrupted treatment. Conclusions To our knowledge, this is the first systematic review of the efficacy and safety of excimer lamp treatment for vitiligo. Excimer lamps, excimer laser, and NB-UVB are all safe and effective in repigmentation of vitiligo lesions. Safety, effectiveness, and cost are considerations when choosing treatment. |
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Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-AnalysisBackground Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning the best treatment method. Objective We aimed to systematically review and meta-analyze published data comparing the efficacy and adverse effects of monochromatic excimer lamps versus excimer laser and narrowband ultraviolet B (NB-UVB) in treating vitiligo. Methods A systematic search of PubMed, EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), and clinical trials registries identified randomized controlled trials that included vitiligo patients, regardless of age, sex, or study language. We evaluated studies comparing excimer lamps with excimer laser or NB-UVB phototherapy. Results The review included six studies (411 patients, 764 lesions). No study found significantly different efficacy between excimer lamps and excimer laser using the outcomes of >= 50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84-1.11] and >= 75 % repigmentation (RR = 0.96, 95 % CI 0.71-1.30). Likewise, no study found significant differences between excimer lamps and NB-UVB (RR = 1.14, 95 % CI 0.88-1.48 for >= 50 % repigmentation; RR = 1.81, 95 % CI 0.11-29.52 for >= 75 % repigmentation). Adverse effects were mild, including pruritus, burning sensation, and dryness, none of which interrupted treatment. Conclusions To our knowledge, this is the first systematic review of the efficacy and safety of excimer lamp treatment for vitiligo. Excimer lamps, excimer laser, and NB-UVB are all safe and effective in repigmentation of vitiligo lesions. Safety, effectiveness, and cost are considerations when choosing treatment.Fed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Div Emergency Med & Evidence Based Med, Sao Paulo, BrazilSanto Amaro Univ UNISA, Discipline Rheumatol, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Internal Med & Evidence Based Med, Sao Paulo, BrazilBrazilian Cochrane Ctr, Sao Paulo, BrazilUniv Fed Sao Paulo, Disciplina Med Baseada Evidencia, Rua Botucatu,740-3 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Div Emergency Med & Evidence Based Med, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Internal Med & Evidence Based Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Disciplina Med Baseada Evidencia, Rua Botucatu,740-3 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, BrazilWeb of ScienceAdis Int Ltd2020-10-30T18:46:32Z2020-10-30T18:46:32Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion23-32https://doi.org/10.1007/s40257-015-0164-2American Journal Of Clinical Dermatology. Northcote, v. 17, n. 1, p. 23-32, 2016.10.1007/s40257-015-0164-21175-0561https://repositorio.unifesp.br/handle/11600/58500WOS:000368988100003engAmerican Journal Of Clinical DermatologyNorthcoteinfo:eu-repo/semantics/openAccessLopes, Celso [UNIFESP]Trevisani, Virginia Fernandes Moca [UNIFESP]Melnik, Tamara [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T14:22:54Zoai:repositorio.unifesp.br/:11600/58500Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T14:22:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis |
title |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis |
spellingShingle |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis Lopes, Celso [UNIFESP] |
title_short |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis |
title_full |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis |
title_fullStr |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis |
title_full_unstemmed |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis |
title_sort |
Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis |
author |
Lopes, Celso [UNIFESP] |
author_facet |
Lopes, Celso [UNIFESP] Trevisani, Virginia Fernandes Moca [UNIFESP] Melnik, Tamara [UNIFESP] |
author_role |
author |
author2 |
Trevisani, Virginia Fernandes Moca [UNIFESP] Melnik, Tamara [UNIFESP] |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Lopes, Celso [UNIFESP] Trevisani, Virginia Fernandes Moca [UNIFESP] Melnik, Tamara [UNIFESP] |
description |
Background Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning the best treatment method. Objective We aimed to systematically review and meta-analyze published data comparing the efficacy and adverse effects of monochromatic excimer lamps versus excimer laser and narrowband ultraviolet B (NB-UVB) in treating vitiligo. Methods A systematic search of PubMed, EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), and clinical trials registries identified randomized controlled trials that included vitiligo patients, regardless of age, sex, or study language. We evaluated studies comparing excimer lamps with excimer laser or NB-UVB phototherapy. Results The review included six studies (411 patients, 764 lesions). No study found significantly different efficacy between excimer lamps and excimer laser using the outcomes of >= 50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84-1.11] and >= 75 % repigmentation (RR = 0.96, 95 % CI 0.71-1.30). Likewise, no study found significant differences between excimer lamps and NB-UVB (RR = 1.14, 95 % CI 0.88-1.48 for >= 50 % repigmentation; RR = 1.81, 95 % CI 0.11-29.52 for >= 75 % repigmentation). Adverse effects were mild, including pruritus, burning sensation, and dryness, none of which interrupted treatment. Conclusions To our knowledge, this is the first systematic review of the efficacy and safety of excimer lamp treatment for vitiligo. Excimer lamps, excimer laser, and NB-UVB are all safe and effective in repigmentation of vitiligo lesions. Safety, effectiveness, and cost are considerations when choosing treatment. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2020-10-30T18:46:32Z 2020-10-30T18:46:32Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1007/s40257-015-0164-2 American Journal Of Clinical Dermatology. Northcote, v. 17, n. 1, p. 23-32, 2016. 10.1007/s40257-015-0164-2 1175-0561 https://repositorio.unifesp.br/handle/11600/58500 WOS:000368988100003 |
url |
https://doi.org/10.1007/s40257-015-0164-2 https://repositorio.unifesp.br/handle/11600/58500 |
identifier_str_mv |
American Journal Of Clinical Dermatology. Northcote, v. 17, n. 1, p. 23-32, 2016. 10.1007/s40257-015-0164-2 1175-0561 WOS:000368988100003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
American Journal Of Clinical Dermatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
23-32 |
dc.coverage.none.fl_str_mv |
Northcote |
dc.publisher.none.fl_str_mv |
Adis Int Ltd |
publisher.none.fl_str_mv |
Adis Int Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268346891239424 |