Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1113/JP272541 https://repositorio.unifesp.br/handle/11600/56847 |
Resumo: | In the present study, we investigated the effect of fish oil (FO) on metabolism and adipokine production by adipocytes from s.c. (inguinal |
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Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytesIn the present study, we investigated the effect of fish oil (FO) on metabolism and adipokine production by adipocytes from s.c. (inguinalING) and visceral (retroperitonealRP) white adipose depots in high-fat (HF) diet-induced obese mice. Mice were divided into CO (control diet), CO+FO, HF and HF+FO groups. The HF group presented higher body weight, glucose intolerance, insulin resistance, higher plasma total and low-density lipoprotein cholesterol levels, and greater weights of ING and RP adipose depots accompanied by hypertrophy of the adipocytes. FO exerted anti-obesogenic effects associated with beneficial effects on dyslipidaemia and insulin resistance in mice fed a HF diet (HF+FO group). HF raised RP adipocyte lipolysis and the production of pro-inflammatory cytokines and reduced de novo synthesis of fatty acids, whereas, in ING adipocytes, it decreased glucose uptake and adiponectin secretion but did not change lipolysis. Therefore, the adipose depots play different roles in HF diet-induced insulin resistance according to their location in the body. Concerning cytokine secretion, adipocytes per se in addition to white adopise tissue infiltrated leukocytes have to be considered in the aetiology of the comorbidities associated with obesity. Evidence is presented showing that previous and concomitant administration of FO can prevent changes in metabolism and the secretion of hormones and cytokines in ING and RP adipocytes induced by HF.Univ Fed Sao Paulo, Dept Biol Sci, Inst Environm Sci Chem & Pharmaceut, 210 Sao Nicolau St, BR-09913030 Diadema, BrazilUniv Sao Paulo, Dept Physiol & Biophys, Inst Biomed Sci, Sao Paulo, BrazilState Univ Goias, Campus Exact Sci & Technol, Anapolis, BrazilDepartment of Biological Sciences, Institute of Environmental Sciences, Chemical and Pharmaceutical, Universidade Federal de São Paulo (UNIFESP), Diadema, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Guggenheim FoundationFAPESP: 2011/51627-8FAPESP: 2010/07596-8FAPESP: 2010/05669-8FAPESP: 2013/03268-4Wiley2020-07-31T12:47:29Z2020-07-31T12:47:29Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6301-6317http://dx.doi.org/10.1113/JP272541Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6301-6317, 2016.10.1113/JP2725410022-3751https://repositorio.unifesp.br/handle/11600/56847WOS:000387084200019engJournal Of Physiology-LondonHobokeninfo:eu-repo/semantics/openAccessSá, Roberta Dourado Cavalcante da Cunha de [UNIFESP]Crisma, Amanda R.Cruz, Maysa Mariana [UNIFESP]Martins, Amanda R.Masi, Laureane N.do Amaral, Catia L.Curi, R.Alonso-Vale, Maria Isabel Cardoso [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-28T17:04:55Zoai:repositorio.unifesp.br/:11600/56847Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-28T17:04:55Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes |
| title |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes |
| spellingShingle |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes Sá, Roberta Dourado Cavalcante da Cunha de [UNIFESP] |
| title_short |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes |
| title_full |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes |
| title_fullStr |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes |
| title_full_unstemmed |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes |
| title_sort |
Fish oil prevents changes induced by a high-fat diet on metabolism and adipokine secretion in mice subcutaneous and visceral adipocytes |
| author |
Sá, Roberta Dourado Cavalcante da Cunha de [UNIFESP] |
| author_facet |
Sá, Roberta Dourado Cavalcante da Cunha de [UNIFESP] Crisma, Amanda R. Cruz, Maysa Mariana [UNIFESP] Martins, Amanda R. Masi, Laureane N. do Amaral, Catia L. Curi, R. Alonso-Vale, Maria Isabel Cardoso [UNIFESP] |
| author_role |
author |
| author2 |
Crisma, Amanda R. Cruz, Maysa Mariana [UNIFESP] Martins, Amanda R. Masi, Laureane N. do Amaral, Catia L. Curi, R. Alonso-Vale, Maria Isabel Cardoso [UNIFESP] |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Sá, Roberta Dourado Cavalcante da Cunha de [UNIFESP] Crisma, Amanda R. Cruz, Maysa Mariana [UNIFESP] Martins, Amanda R. Masi, Laureane N. do Amaral, Catia L. Curi, R. Alonso-Vale, Maria Isabel Cardoso [UNIFESP] |
| description |
In the present study, we investigated the effect of fish oil (FO) on metabolism and adipokine production by adipocytes from s.c. (inguinal |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2020-07-31T12:47:29Z 2020-07-31T12:47:29Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1113/JP272541 Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6301-6317, 2016. 10.1113/JP272541 0022-3751 https://repositorio.unifesp.br/handle/11600/56847 WOS:000387084200019 |
| url |
http://dx.doi.org/10.1113/JP272541 https://repositorio.unifesp.br/handle/11600/56847 |
| identifier_str_mv |
Journal Of Physiology-London. Hoboken, v. 594, n. 21, p. 6301-6317, 2016. 10.1113/JP272541 0022-3751 WOS:000387084200019 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal Of Physiology-London |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
6301-6317 |
| dc.coverage.none.fl_str_mv |
Hoboken |
| dc.publisher.none.fl_str_mv |
Wiley |
| publisher.none.fl_str_mv |
Wiley |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1814268405315796992 |