Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2014/870634 http://hdl.handle.net/11449/117244 |
Resumo: | Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption of insulin signaling, glucose intolerance, and inflammation. Macadamia oil administration has been shown to improve lipid profile in humans. We evaluated the effect of macadamia oil supplementation on insulin sensitivity, inflammation, lipid profile, and adipocyte size in high-fat diet (HF) induced obesity in mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control diet (CD), (b) HF, (c) CD supplemented with macadamia oil by gavage at 2g/Kg of body weight, three times per week, for 12 weeks (CD + MO), and (d) HF diet supplemented with macadamia oil (HF + MO). CD and HF mice were supplemented with water. HF mice showed hypercholesterolemia and decreased insulin sensitivity as also previously shown. HF induced inflammation in adipose tissue and peritoneal macrophages, as well as adipocyte hypertrophy. Macadamia oil supplementation attenuated hypertrophy of adipocytes and inflammation in the adipose tissue and macrophages. |
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Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese MiceExcess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption of insulin signaling, glucose intolerance, and inflammation. Macadamia oil administration has been shown to improve lipid profile in humans. We evaluated the effect of macadamia oil supplementation on insulin sensitivity, inflammation, lipid profile, and adipocyte size in high-fat diet (HF) induced obesity in mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control diet (CD), (b) HF, (c) CD supplemented with macadamia oil by gavage at 2g/Kg of body weight, three times per week, for 12 weeks (CD + MO), and (d) HF diet supplemented with macadamia oil (HF + MO). CD and HF mice were supplemented with water. HF mice showed hypercholesterolemia and decreased insulin sensitivity as also previously shown. HF induced inflammation in adipose tissue and peritoneal macrophages, as well as adipocyte hypertrophy. Macadamia oil supplementation attenuated hypertrophy of adipocytes and inflammation in the adipose tissue and macrophages.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Dept Biol Celular & Desenvolvimento, BR-05508000 Sao Paulo, BrazilUniv Estadual Paulista, UNESP, Dept Educ Fis, Programa Posgrad Ciencia Motricidad, BR-13506900 Rio Claro, SP, BrazilUniv Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508000 Sao Paulo, BrazilUniv Sao Judas Tadeu, Dept Ciencias Biol, Lab Movimento Humano, BR-05503001 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, BR-04023901 Sao Paulo, BrazilUniv Sao Paulo, Inst Biociencias, Dept Fisiol Geral, BR-05508090 Sao Paulo, BrazilUniv Cruzeiro Sul, Inst Ciencias Atividade Fis & Esporte, Programa Posgrad Ciencia Movimento Humano, BR-01506000 Sao Paulo, BrazilUniv Estadual Paulista, UNESP, Dept Educ Fis, Programa Posgrad Ciencia Motricidad, BR-13506900 Rio Claro, SP, BrazilHindawi Publishing CorporationUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Univ Sao Judas TadeuUniversidade Federal de São Paulo (UNIFESP)Univ Cruzeiro SulLima, Edson A.Silveira, Loreana S. [UNESP]Masi, Laureane N.Crisma, Amanda R.Davanso, Mariana R.Souza, Gabriel I. G.Santamarina, Aline B.Moreira, Renata G.Martins, Amanda RoqueSousa, Luis Gustavo O. deHirabara, Sandro M.Rosa Neto, Jose C.2015-03-18T15:55:38Z2015-03-18T15:55:38Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/epub+zipapplication/pdfhttp://dx.doi.org/10.1155/2014/870634Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 9 p., 2014.0962-9351http://hdl.handle.net/11449/11724410.1155/2014/870634WOS:000344673400001WOS000344673400001.pdfWOS000344673400001.epubWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMediators Of Inflammation3.5491,370info:eu-repo/semantics/openAccess2024-01-16T06:30:10Zoai:repositorio.unesp.br:11449/117244Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:09:27.504351Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice |
title |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice |
spellingShingle |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice Lima, Edson A. |
title_short |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice |
title_full |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice |
title_fullStr |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice |
title_full_unstemmed |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice |
title_sort |
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice |
author |
Lima, Edson A. |
author_facet |
Lima, Edson A. Silveira, Loreana S. [UNESP] Masi, Laureane N. Crisma, Amanda R. Davanso, Mariana R. Souza, Gabriel I. G. Santamarina, Aline B. Moreira, Renata G. Martins, Amanda Roque Sousa, Luis Gustavo O. de Hirabara, Sandro M. Rosa Neto, Jose C. |
author_role |
author |
author2 |
Silveira, Loreana S. [UNESP] Masi, Laureane N. Crisma, Amanda R. Davanso, Mariana R. Souza, Gabriel I. G. Santamarina, Aline B. Moreira, Renata G. Martins, Amanda Roque Sousa, Luis Gustavo O. de Hirabara, Sandro M. Rosa Neto, Jose C. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) Univ Sao Judas Tadeu Universidade Federal de São Paulo (UNIFESP) Univ Cruzeiro Sul |
dc.contributor.author.fl_str_mv |
Lima, Edson A. Silveira, Loreana S. [UNESP] Masi, Laureane N. Crisma, Amanda R. Davanso, Mariana R. Souza, Gabriel I. G. Santamarina, Aline B. Moreira, Renata G. Martins, Amanda Roque Sousa, Luis Gustavo O. de Hirabara, Sandro M. Rosa Neto, Jose C. |
description |
Excess of saturated fatty acids in the diet has been associated with obesity, leading to systemic disruption of insulin signaling, glucose intolerance, and inflammation. Macadamia oil administration has been shown to improve lipid profile in humans. We evaluated the effect of macadamia oil supplementation on insulin sensitivity, inflammation, lipid profile, and adipocyte size in high-fat diet (HF) induced obesity in mice. C57BL/6 male mice (8 weeks) were divided into four groups: (a) control diet (CD), (b) HF, (c) CD supplemented with macadamia oil by gavage at 2g/Kg of body weight, three times per week, for 12 weeks (CD + MO), and (d) HF diet supplemented with macadamia oil (HF + MO). CD and HF mice were supplemented with water. HF mice showed hypercholesterolemia and decreased insulin sensitivity as also previously shown. HF induced inflammation in adipose tissue and peritoneal macrophages, as well as adipocyte hypertrophy. Macadamia oil supplementation attenuated hypertrophy of adipocytes and inflammation in the adipose tissue and macrophages. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01-01 2015-03-18T15:55:38Z 2015-03-18T15:55:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2014/870634 Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 9 p., 2014. 0962-9351 http://hdl.handle.net/11449/117244 10.1155/2014/870634 WOS:000344673400001 WOS000344673400001.pdf WOS000344673400001.epub |
url |
http://dx.doi.org/10.1155/2014/870634 http://hdl.handle.net/11449/117244 |
identifier_str_mv |
Mediators Of Inflammation. New York: Hindawi Publishing Corporation, 9 p., 2014. 0962-9351 10.1155/2014/870634 WOS:000344673400001 WOS000344673400001.pdf WOS000344673400001.epub |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mediators Of Inflammation 3.549 1,370 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
9 application/epub+zip application/pdf |
dc.publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
publisher.none.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129495545151488 |