Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects

Detalhes bibliográficos
Autor(a) principal: Jardim, José Roberto [UNIFESP]
Data de Publicação: 2007
Outros Autores: Camelier, Aquiles Assunção [UNIFESP], Dal Corso, Simone [UNIFESP], Rodrigues, José Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000dz4z
DOI: 10.1016/j.rmed.2006.10.017
Texto Completo: http://dx.doi.org/10.1016/j.rmed.2006.10.017
http://repositorio.unifesp.br/handle/11600/29828
Resumo: Objective: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects.Design: A randomized, double blind and placebo-controlled study.Setting: A university-affiliated teaching hospital.Participants: Thirteen normal volunteers selected from a graduation course.Intervention: Subjects were randomly allocated to receive a placebo or corticosteroid (flunisolide) to be inhaled twice a day for 4 weeks. After 2 weeks of a washout period, subjects who were receiving the placebo, received flunisolide and vise versa for another 4-week period.Measurements and results: Spirometry was used to define the volunteers as being normal in terms of pulmonary function. During the study, subjects performed tests of respiratory muscle function (strength and endurance), measurements of handgrip strength and endurance and anthropometric measurements. Muscle strength was measured each week while muscle endurance was measured every 2 weeks. There was no significant difference in the maximal inspiratory and expiratory pressure and handgrip strength during weeks 1-4 when the subjects used either flunisolide or placebo. However, we observed an increase in the endurance time of the respiratory and handgrip muscles in the 4th week of both flunisolide and placebo use, what may be considered due to a learning effect.Conclusion: Inhalation of flunisolide by normal subjects for 1 month does not cause any acute or clinically perceived effect in the peripheral or respiratory muscles. (C) 2007 Published by Elsevier B.V.
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spelling Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjectsinhaled corticosteroidssteroid myopathyrespiratory muscle strength and enduranceperipheral muscleObjective: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects.Design: A randomized, double blind and placebo-controlled study.Setting: A university-affiliated teaching hospital.Participants: Thirteen normal volunteers selected from a graduation course.Intervention: Subjects were randomly allocated to receive a placebo or corticosteroid (flunisolide) to be inhaled twice a day for 4 weeks. After 2 weeks of a washout period, subjects who were receiving the placebo, received flunisolide and vise versa for another 4-week period.Measurements and results: Spirometry was used to define the volunteers as being normal in terms of pulmonary function. During the study, subjects performed tests of respiratory muscle function (strength and endurance), measurements of handgrip strength and endurance and anthropometric measurements. Muscle strength was measured each week while muscle endurance was measured every 2 weeks. There was no significant difference in the maximal inspiratory and expiratory pressure and handgrip strength during weeks 1-4 when the subjects used either flunisolide or placebo. However, we observed an increase in the endurance time of the respiratory and handgrip muscles in the 4th week of both flunisolide and placebo use, what may be considered due to a learning effect.Conclusion: Inhalation of flunisolide by normal subjects for 1 month does not cause any acute or clinically perceived effect in the peripheral or respiratory muscles. (C) 2007 Published by Elsevier B.V.Universidade Federal de São Paulo, Resp Div, BR-04023062 São Paulo, BrazilUniv Fed Bahia, Div Resp, Ufba, BA, BrazilUniv Metropolitana Santos, Resp Div, São Paulo, BrazilUniversidade Federal de São Paulo, Resp Div, BR-04023062 São Paulo, BrazilWeb of ScienceW B Saunders Co LtdUniversidade Federal de São Paulo (UNIFESP)Universidade Federal da Bahia (UFBA)Univ Metropolitana SantosJardim, José Roberto [UNIFESP]Camelier, Aquiles Assunção [UNIFESP]Dal Corso, Simone [UNIFESP]Rodrigues, José Eduardo2016-01-24T13:48:49Z2016-01-24T13:48:49Z2007-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1594-1599application/pdfhttp://dx.doi.org/10.1016/j.rmed.2006.10.017Respiratory Medicine. London: W B Saunders Co Ltd, v. 101, n. 7, p. 1594-1599, 2007.10.1016/j.rmed.2006.10.017WOS000247765900032.pdf0954-6111http://repositorio.unifesp.br/handle/11600/29828WOS:000247765900032ark:/48912/001300000dz4zengRespiratory Medicineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T05:57:25Zoai:repositorio.unifesp.br/:11600/29828Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:14:02.937491Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
title Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
spellingShingle Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
Jardim, José Roberto [UNIFESP]
inhaled corticosteroids
steroid myopathy
respiratory muscle strength and endurance
peripheral muscle
Jardim, José Roberto [UNIFESP]
inhaled corticosteroids
steroid myopathy
respiratory muscle strength and endurance
peripheral muscle
title_short Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
title_full Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
title_fullStr Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
title_full_unstemmed Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
title_sort Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
author Jardim, José Roberto [UNIFESP]
author_facet Jardim, José Roberto [UNIFESP]
Jardim, José Roberto [UNIFESP]
Camelier, Aquiles Assunção [UNIFESP]
Dal Corso, Simone [UNIFESP]
Rodrigues, José Eduardo
Camelier, Aquiles Assunção [UNIFESP]
Dal Corso, Simone [UNIFESP]
Rodrigues, José Eduardo
author_role author
author2 Camelier, Aquiles Assunção [UNIFESP]
Dal Corso, Simone [UNIFESP]
Rodrigues, José Eduardo
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade Federal da Bahia (UFBA)
Univ Metropolitana Santos
dc.contributor.author.fl_str_mv Jardim, José Roberto [UNIFESP]
Camelier, Aquiles Assunção [UNIFESP]
Dal Corso, Simone [UNIFESP]
Rodrigues, José Eduardo
dc.subject.por.fl_str_mv inhaled corticosteroids
steroid myopathy
respiratory muscle strength and endurance
peripheral muscle
topic inhaled corticosteroids
steroid myopathy
respiratory muscle strength and endurance
peripheral muscle
description Objective: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects.Design: A randomized, double blind and placebo-controlled study.Setting: A university-affiliated teaching hospital.Participants: Thirteen normal volunteers selected from a graduation course.Intervention: Subjects were randomly allocated to receive a placebo or corticosteroid (flunisolide) to be inhaled twice a day for 4 weeks. After 2 weeks of a washout period, subjects who were receiving the placebo, received flunisolide and vise versa for another 4-week period.Measurements and results: Spirometry was used to define the volunteers as being normal in terms of pulmonary function. During the study, subjects performed tests of respiratory muscle function (strength and endurance), measurements of handgrip strength and endurance and anthropometric measurements. Muscle strength was measured each week while muscle endurance was measured every 2 weeks. There was no significant difference in the maximal inspiratory and expiratory pressure and handgrip strength during weeks 1-4 when the subjects used either flunisolide or placebo. However, we observed an increase in the endurance time of the respiratory and handgrip muscles in the 4th week of both flunisolide and placebo use, what may be considered due to a learning effect.Conclusion: Inhalation of flunisolide by normal subjects for 1 month does not cause any acute or clinically perceived effect in the peripheral or respiratory muscles. (C) 2007 Published by Elsevier B.V.
publishDate 2007
dc.date.none.fl_str_mv 2007-07-01
2016-01-24T13:48:49Z
2016-01-24T13:48:49Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.rmed.2006.10.017
Respiratory Medicine. London: W B Saunders Co Ltd, v. 101, n. 7, p. 1594-1599, 2007.
10.1016/j.rmed.2006.10.017
WOS000247765900032.pdf
0954-6111
http://repositorio.unifesp.br/handle/11600/29828
WOS:000247765900032
dc.identifier.dark.fl_str_mv ark:/48912/001300000dz4z
url http://dx.doi.org/10.1016/j.rmed.2006.10.017
http://repositorio.unifesp.br/handle/11600/29828
identifier_str_mv Respiratory Medicine. London: W B Saunders Co Ltd, v. 101, n. 7, p. 1594-1599, 2007.
10.1016/j.rmed.2006.10.017
WOS000247765900032.pdf
0954-6111
WOS:000247765900032
ark:/48912/001300000dz4z
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Respiratory Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1594-1599
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822183940871421952
dc.identifier.doi.none.fl_str_mv 10.1016/j.rmed.2006.10.017