Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/001300000dz4z |
DOI: | 10.1016/j.rmed.2006.10.017 |
Texto Completo: | http://dx.doi.org/10.1016/j.rmed.2006.10.017 http://repositorio.unifesp.br/handle/11600/29828 |
Resumo: | Objective: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects.Design: A randomized, double blind and placebo-controlled study.Setting: A university-affiliated teaching hospital.Participants: Thirteen normal volunteers selected from a graduation course.Intervention: Subjects were randomly allocated to receive a placebo or corticosteroid (flunisolide) to be inhaled twice a day for 4 weeks. After 2 weeks of a washout period, subjects who were receiving the placebo, received flunisolide and vise versa for another 4-week period.Measurements and results: Spirometry was used to define the volunteers as being normal in terms of pulmonary function. During the study, subjects performed tests of respiratory muscle function (strength and endurance), measurements of handgrip strength and endurance and anthropometric measurements. Muscle strength was measured each week while muscle endurance was measured every 2 weeks. There was no significant difference in the maximal inspiratory and expiratory pressure and handgrip strength during weeks 1-4 when the subjects used either flunisolide or placebo. However, we observed an increase in the endurance time of the respiratory and handgrip muscles in the 4th week of both flunisolide and placebo use, what may be considered due to a learning effect.Conclusion: Inhalation of flunisolide by normal subjects for 1 month does not cause any acute or clinically perceived effect in the peripheral or respiratory muscles. (C) 2007 Published by Elsevier B.V. |
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Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjectsinhaled corticosteroidssteroid myopathyrespiratory muscle strength and enduranceperipheral muscleObjective: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects.Design: A randomized, double blind and placebo-controlled study.Setting: A university-affiliated teaching hospital.Participants: Thirteen normal volunteers selected from a graduation course.Intervention: Subjects were randomly allocated to receive a placebo or corticosteroid (flunisolide) to be inhaled twice a day for 4 weeks. After 2 weeks of a washout period, subjects who were receiving the placebo, received flunisolide and vise versa for another 4-week period.Measurements and results: Spirometry was used to define the volunteers as being normal in terms of pulmonary function. During the study, subjects performed tests of respiratory muscle function (strength and endurance), measurements of handgrip strength and endurance and anthropometric measurements. Muscle strength was measured each week while muscle endurance was measured every 2 weeks. There was no significant difference in the maximal inspiratory and expiratory pressure and handgrip strength during weeks 1-4 when the subjects used either flunisolide or placebo. However, we observed an increase in the endurance time of the respiratory and handgrip muscles in the 4th week of both flunisolide and placebo use, what may be considered due to a learning effect.Conclusion: Inhalation of flunisolide by normal subjects for 1 month does not cause any acute or clinically perceived effect in the peripheral or respiratory muscles. (C) 2007 Published by Elsevier B.V.Universidade Federal de São Paulo, Resp Div, BR-04023062 São Paulo, BrazilUniv Fed Bahia, Div Resp, Ufba, BA, BrazilUniv Metropolitana Santos, Resp Div, São Paulo, BrazilUniversidade Federal de São Paulo, Resp Div, BR-04023062 São Paulo, BrazilWeb of ScienceW B Saunders Co LtdUniversidade Federal de São Paulo (UNIFESP)Universidade Federal da Bahia (UFBA)Univ Metropolitana SantosJardim, José Roberto [UNIFESP]Camelier, Aquiles Assunção [UNIFESP]Dal Corso, Simone [UNIFESP]Rodrigues, José Eduardo2016-01-24T13:48:49Z2016-01-24T13:48:49Z2007-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1594-1599application/pdfhttp://dx.doi.org/10.1016/j.rmed.2006.10.017Respiratory Medicine. London: W B Saunders Co Ltd, v. 101, n. 7, p. 1594-1599, 2007.10.1016/j.rmed.2006.10.017WOS000247765900032.pdf0954-6111http://repositorio.unifesp.br/handle/11600/29828WOS:000247765900032ark:/48912/001300000dz4zengRespiratory Medicineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T05:57:25Zoai:repositorio.unifesp.br/:11600/29828Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:14:02.937491Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects |
title |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects |
spellingShingle |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects Jardim, José Roberto [UNIFESP] inhaled corticosteroids steroid myopathy respiratory muscle strength and endurance peripheral muscle Jardim, José Roberto [UNIFESP] inhaled corticosteroids steroid myopathy respiratory muscle strength and endurance peripheral muscle |
title_short |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects |
title_full |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects |
title_fullStr |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects |
title_full_unstemmed |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects |
title_sort |
Strength and endurance of the respiratory and handgrip muscles after the use of flunisolide in normal subjects |
author |
Jardim, José Roberto [UNIFESP] |
author_facet |
Jardim, José Roberto [UNIFESP] Jardim, José Roberto [UNIFESP] Camelier, Aquiles Assunção [UNIFESP] Dal Corso, Simone [UNIFESP] Rodrigues, José Eduardo Camelier, Aquiles Assunção [UNIFESP] Dal Corso, Simone [UNIFESP] Rodrigues, José Eduardo |
author_role |
author |
author2 |
Camelier, Aquiles Assunção [UNIFESP] Dal Corso, Simone [UNIFESP] Rodrigues, José Eduardo |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal da Bahia (UFBA) Univ Metropolitana Santos |
dc.contributor.author.fl_str_mv |
Jardim, José Roberto [UNIFESP] Camelier, Aquiles Assunção [UNIFESP] Dal Corso, Simone [UNIFESP] Rodrigues, José Eduardo |
dc.subject.por.fl_str_mv |
inhaled corticosteroids steroid myopathy respiratory muscle strength and endurance peripheral muscle |
topic |
inhaled corticosteroids steroid myopathy respiratory muscle strength and endurance peripheral muscle |
description |
Objective: To evaluate the effects of the inhaled flunisolide upon the strength and endurance of the respiratory and peripheral muscles of normal subjects.Design: A randomized, double blind and placebo-controlled study.Setting: A university-affiliated teaching hospital.Participants: Thirteen normal volunteers selected from a graduation course.Intervention: Subjects were randomly allocated to receive a placebo or corticosteroid (flunisolide) to be inhaled twice a day for 4 weeks. After 2 weeks of a washout period, subjects who were receiving the placebo, received flunisolide and vise versa for another 4-week period.Measurements and results: Spirometry was used to define the volunteers as being normal in terms of pulmonary function. During the study, subjects performed tests of respiratory muscle function (strength and endurance), measurements of handgrip strength and endurance and anthropometric measurements. Muscle strength was measured each week while muscle endurance was measured every 2 weeks. There was no significant difference in the maximal inspiratory and expiratory pressure and handgrip strength during weeks 1-4 when the subjects used either flunisolide or placebo. However, we observed an increase in the endurance time of the respiratory and handgrip muscles in the 4th week of both flunisolide and placebo use, what may be considered due to a learning effect.Conclusion: Inhalation of flunisolide by normal subjects for 1 month does not cause any acute or clinically perceived effect in the peripheral or respiratory muscles. (C) 2007 Published by Elsevier B.V. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-07-01 2016-01-24T13:48:49Z 2016-01-24T13:48:49Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.rmed.2006.10.017 Respiratory Medicine. London: W B Saunders Co Ltd, v. 101, n. 7, p. 1594-1599, 2007. 10.1016/j.rmed.2006.10.017 WOS000247765900032.pdf 0954-6111 http://repositorio.unifesp.br/handle/11600/29828 WOS:000247765900032 |
dc.identifier.dark.fl_str_mv |
ark:/48912/001300000dz4z |
url |
http://dx.doi.org/10.1016/j.rmed.2006.10.017 http://repositorio.unifesp.br/handle/11600/29828 |
identifier_str_mv |
Respiratory Medicine. London: W B Saunders Co Ltd, v. 101, n. 7, p. 1594-1599, 2007. 10.1016/j.rmed.2006.10.017 WOS000247765900032.pdf 0954-6111 WOS:000247765900032 ark:/48912/001300000dz4z |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Respiratory Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1594-1599 application/pdf |
dc.publisher.none.fl_str_mv |
W B Saunders Co Ltd |
publisher.none.fl_str_mv |
W B Saunders Co Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1822183940871421952 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.rmed.2006.10.017 |