Influence of minoxidil on ischemic cutaneous flaps in rats

Detalhes bibliográficos
Autor(a) principal: Bittencourt, Rogério De Castro
Data de Publicação: 2005
Outros Autores: Biondo-simões, Maria De Lourdes Pessole [UNIFESP], Paula, Josué Brunginski De, Martynetz, Juliano, Groth, Anne
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-86502005000600010
http://repositorio.unifesp.br/handle/11600/2758
Resumo: PURPOSE: To evaluate the influence of minoxidil, a well known vasodilator, on ischemic flap necrosis prevention in rats. METHODS: Ventral cutaneous flaps, measuring 8x4cm, were designed in 20 Wistar rats based on the right cranial epigastric artery. In the experiment group, 50 mg/kg/day of minoxidil sulfate was administered by orogastric tube and the same amount of saline solution was administered to the control group. Such procedure was initiated 24h before surgery and kept once a day through the 7th postoperative day. Microcirculation was evaluated with laser fluxometry 24h before surgical procedure, at immediate postoperative and at the 7th postoperative day. Flap necrosis area was evaluated by 2 methods: planimetry and weight/paper ratio. RESULTS: A significant flow increase in distal and medial extremity at M1 (medial point 1) (p=0,0484) was observed in the experiment group. There was significant difference in flap necrosis prevention in the experiment group (p=0,0433), although after necrosis took place there was no significant difference in necrosis size. (p=0,1051 and p=0,2799). CONCLUSION: Minoxidil sulfate is effective in avoiding necrosis in ischemic flaps, but after necrosis is present there is no difference in survival area between experimental and control groups.
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spelling Influence of minoxidil on ischemic cutaneous flaps in ratsInfluência do minoxidil sobre retalhos cutâneos isquêmicos em ratosSurgical FlapsVasodilator AgentsMinoxidilWound HealingRatsRetalhos CirúrgicosVasodilatadoresMinoxidilCicatrização de FeridasRatosPURPOSE: To evaluate the influence of minoxidil, a well known vasodilator, on ischemic flap necrosis prevention in rats. METHODS: Ventral cutaneous flaps, measuring 8x4cm, were designed in 20 Wistar rats based on the right cranial epigastric artery. In the experiment group, 50 mg/kg/day of minoxidil sulfate was administered by orogastric tube and the same amount of saline solution was administered to the control group. Such procedure was initiated 24h before surgery and kept once a day through the 7th postoperative day. Microcirculation was evaluated with laser fluxometry 24h before surgical procedure, at immediate postoperative and at the 7th postoperative day. Flap necrosis area was evaluated by 2 methods: planimetry and weight/paper ratio. RESULTS: A significant flow increase in distal and medial extremity at M1 (medial point 1) (p=0,0484) was observed in the experiment group. There was significant difference in flap necrosis prevention in the experiment group (p=0,0433), although after necrosis took place there was no significant difference in necrosis size. (p=0,1051 and p=0,2799). CONCLUSION: Minoxidil sulfate is effective in avoiding necrosis in ischemic flaps, but after necrosis is present there is no difference in survival area between experimental and control groups.OBJETIVOS: Avaliar a influência do minoxidil, um vasodilatador, na prevenção de necrose, em retalhos isquêmicos, em ratos. MÉTODOS: Preparam-se retalhos cutâneos ventrais, medindo 8x4 cm, baseados na artéria epigástrica cranial direita, em 20 ratos - Wistar. Administrou-se 50 mg/kg/dia de sulfato de minoxidil aos ratos do grupo experimento e o mesmo volume de solução salina isotônica aos do grupo controle, por sonda oro-gástrica. Iniciou-se o tratamento 24 horas antes da operação e manteve-se, diariamente, por 7 dias, no pós-operatório. Realizou-se a avaliação da microcirculação dos retalhos fluxometria a laser 24 horas antes da operação, no pós-operatório imediato e após 7 dias. Desenhou-se a área de necrose do retalho em molde e avaliou-se em relação ao tamanho total por 2 métodos: planimetria e peso/papel. RESULTADOS: Constatou-se aumento de fluxo na extremidade distal e medial (M1) (p=0,0484), no grupo experimento. Houve diferença na prevenção da necrose nos retalhos do grupo experimento (p=0,0433), porém quando esta se instalou, não houve diferença quanto ao tamanho da área necrosada (p=0,1051 e p=0,2799). CONCLUSÃO: O uso de minoxidil é efetivo para evitar a instalação da necrose de retalhos potencialmente isquêmicos, porém, quando o processo se instala, não existe diferença na sobrevida destes, com a dose e a via empregadas neste estudo, em ratos.Catholic University of ParanáPUCPR Cajuru University HospitalBrazilian Society of Plastic SurgeryUNIFESP-EPMCBCSOBRADPECSociety of Plastic SurgeryUNIFESP, EPMSciELOSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaCatholic University of ParanáPUCPR Cajuru University HospitalBrazilian Society of Plastic SurgeryUniversidade Federal de São Paulo (UNIFESP)CBCSOBRADPECSociety of Plastic SurgeryBittencourt, Rogério De CastroBiondo-simões, Maria De Lourdes Pessole [UNIFESP]Paula, Josué Brunginski DeMartynetz, JulianoGroth, Anne2015-06-14T13:31:48Z2015-06-14T13:31:48Z2005-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion450-454application/pdfhttp://dx.doi.org/10.1590/S0102-86502005000600010Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 6, p. 450-454, 2005.10.1590/S0102-86502005000600010S0102-86502005000600010.pdf0102-8650S0102-86502005000600010http://repositorio.unifesp.br/handle/11600/2758engActa Cirurgica Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T14:30:03Zoai:repositorio.unifesp.br/:11600/2758Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T14:30:03Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Influence of minoxidil on ischemic cutaneous flaps in rats
Influência do minoxidil sobre retalhos cutâneos isquêmicos em ratos
title Influence of minoxidil on ischemic cutaneous flaps in rats
spellingShingle Influence of minoxidil on ischemic cutaneous flaps in rats
Bittencourt, Rogério De Castro
Surgical Flaps
Vasodilator Agents
Minoxidil
Wound Healing
Rats
Retalhos Cirúrgicos
Vasodilatadores
Minoxidil
Cicatrização de Feridas
Ratos
title_short Influence of minoxidil on ischemic cutaneous flaps in rats
title_full Influence of minoxidil on ischemic cutaneous flaps in rats
title_fullStr Influence of minoxidil on ischemic cutaneous flaps in rats
title_full_unstemmed Influence of minoxidil on ischemic cutaneous flaps in rats
title_sort Influence of minoxidil on ischemic cutaneous flaps in rats
author Bittencourt, Rogério De Castro
author_facet Bittencourt, Rogério De Castro
Biondo-simões, Maria De Lourdes Pessole [UNIFESP]
Paula, Josué Brunginski De
Martynetz, Juliano
Groth, Anne
author_role author
author2 Biondo-simões, Maria De Lourdes Pessole [UNIFESP]
Paula, Josué Brunginski De
Martynetz, Juliano
Groth, Anne
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Catholic University of Paraná
PUCPR Cajuru University Hospital
Brazilian Society of Plastic Surgery
Universidade Federal de São Paulo (UNIFESP)
CBC
SOBRADPEC
Society of Plastic Surgery
dc.contributor.author.fl_str_mv Bittencourt, Rogério De Castro
Biondo-simões, Maria De Lourdes Pessole [UNIFESP]
Paula, Josué Brunginski De
Martynetz, Juliano
Groth, Anne
dc.subject.por.fl_str_mv Surgical Flaps
Vasodilator Agents
Minoxidil
Wound Healing
Rats
Retalhos Cirúrgicos
Vasodilatadores
Minoxidil
Cicatrização de Feridas
Ratos
topic Surgical Flaps
Vasodilator Agents
Minoxidil
Wound Healing
Rats
Retalhos Cirúrgicos
Vasodilatadores
Minoxidil
Cicatrização de Feridas
Ratos
description PURPOSE: To evaluate the influence of minoxidil, a well known vasodilator, on ischemic flap necrosis prevention in rats. METHODS: Ventral cutaneous flaps, measuring 8x4cm, were designed in 20 Wistar rats based on the right cranial epigastric artery. In the experiment group, 50 mg/kg/day of minoxidil sulfate was administered by orogastric tube and the same amount of saline solution was administered to the control group. Such procedure was initiated 24h before surgery and kept once a day through the 7th postoperative day. Microcirculation was evaluated with laser fluxometry 24h before surgical procedure, at immediate postoperative and at the 7th postoperative day. Flap necrosis area was evaluated by 2 methods: planimetry and weight/paper ratio. RESULTS: A significant flow increase in distal and medial extremity at M1 (medial point 1) (p=0,0484) was observed in the experiment group. There was significant difference in flap necrosis prevention in the experiment group (p=0,0433), although after necrosis took place there was no significant difference in necrosis size. (p=0,1051 and p=0,2799). CONCLUSION: Minoxidil sulfate is effective in avoiding necrosis in ischemic flaps, but after necrosis is present there is no difference in survival area between experimental and control groups.
publishDate 2005
dc.date.none.fl_str_mv 2005-12-01
2015-06-14T13:31:48Z
2015-06-14T13:31:48Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-86502005000600010
Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 6, p. 450-454, 2005.
10.1590/S0102-86502005000600010
S0102-86502005000600010.pdf
0102-8650
S0102-86502005000600010
http://repositorio.unifesp.br/handle/11600/2758
url http://dx.doi.org/10.1590/S0102-86502005000600010
http://repositorio.unifesp.br/handle/11600/2758
identifier_str_mv Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 20, n. 6, p. 450-454, 2005.
10.1590/S0102-86502005000600010
S0102-86502005000600010.pdf
0102-8650
S0102-86502005000600010
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Acta Cirurgica Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 450-454
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
publisher.none.fl_str_mv Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268392417263616

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