Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1249/MSS.0b013e3181e45d08 http://repositorio.unifesp.br/handle/11600/33097 |
Resumo: | DA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. de SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: in the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. in parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy. |
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Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese RatsOBESITYACUTE EXERCISEINSULIN SIGNALINGINFLAMMATIONDA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. de SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: in the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. in parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy.State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Campinas, SP, BrazilUniv São Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14049 Ribeirao Preto, SP, BrazilFed Univ São Paulo UNIFESP, Fac Phys Educ, Dept Biosci, Santos, SP, BrazilUniv So Santa Catarina, Hlth Sci Unit, Postgrad Program Hlth Sci, Exercise Biochem & Physiol Lab, Criciuma, SC, BrazilFed Univ São Paulo UNIFESP, Fac Phys Educ, Dept Biosci, Santos, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2006/06961-9FAPESP: 2006/06960-2Lippincott Williams & WilkinsUniversidade Estadual de Campinas (UNICAMP)Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Univ So Santa CatarinaDa Silva, Adelino S. R.Pauli, José Rodrigo [UNIFESP]Ropelle, Eduardo R.Oliveira, Alexandre G.Cintra, Dennys E.De Souza, Claudio T.Velloso, Licio A.Carvalheira, Jose B. C.Saad, Mario J. A.2016-01-24T14:05:42Z2016-01-24T14:05:42Z2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2180-2188http://dx.doi.org/10.1249/MSS.0b013e3181e45d08Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 12, p. 2180-2188, 2010.10.1249/MSS.0b013e3181e45d080195-9131http://repositorio.unifesp.br/handle/11600/33097WOS:000284353500005engMedicine and Science in Sports and Exerciseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-08-11T11:48:48Zoai:repositorio.unifesp.br/:11600/33097Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-08-11T11:48:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats |
title |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats |
spellingShingle |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats Da Silva, Adelino S. R. OBESITY ACUTE EXERCISE INSULIN SIGNALING INFLAMMATION |
title_short |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats |
title_full |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats |
title_fullStr |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats |
title_full_unstemmed |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats |
title_sort |
Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats |
author |
Da Silva, Adelino S. R. |
author_facet |
Da Silva, Adelino S. R. Pauli, José Rodrigo [UNIFESP] Ropelle, Eduardo R. Oliveira, Alexandre G. Cintra, Dennys E. De Souza, Claudio T. Velloso, Licio A. Carvalheira, Jose B. C. Saad, Mario J. A. |
author_role |
author |
author2 |
Pauli, José Rodrigo [UNIFESP] Ropelle, Eduardo R. Oliveira, Alexandre G. Cintra, Dennys E. De Souza, Claudio T. Velloso, Licio A. Carvalheira, Jose B. C. Saad, Mario J. A. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Univ So Santa Catarina |
dc.contributor.author.fl_str_mv |
Da Silva, Adelino S. R. Pauli, José Rodrigo [UNIFESP] Ropelle, Eduardo R. Oliveira, Alexandre G. Cintra, Dennys E. De Souza, Claudio T. Velloso, Licio A. Carvalheira, Jose B. C. Saad, Mario J. A. |
dc.subject.por.fl_str_mv |
OBESITY ACUTE EXERCISE INSULIN SIGNALING INFLAMMATION |
topic |
OBESITY ACUTE EXERCISE INSULIN SIGNALING INFLAMMATION |
description |
DA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. de SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: in the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. in parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-12-01 2016-01-24T14:05:42Z 2016-01-24T14:05:42Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1249/MSS.0b013e3181e45d08 Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 12, p. 2180-2188, 2010. 10.1249/MSS.0b013e3181e45d08 0195-9131 http://repositorio.unifesp.br/handle/11600/33097 WOS:000284353500005 |
url |
http://dx.doi.org/10.1249/MSS.0b013e3181e45d08 http://repositorio.unifesp.br/handle/11600/33097 |
identifier_str_mv |
Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 12, p. 2180-2188, 2010. 10.1249/MSS.0b013e3181e45d08 0195-9131 WOS:000284353500005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medicine and Science in Sports and Exercise |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2180-2188 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268363801624576 |