Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats

Detalhes bibliográficos
Autor(a) principal: Da Silva, Adelino S. R.
Data de Publicação: 2010
Outros Autores: Pauli, José Rodrigo [UNIFESP], Ropelle, Eduardo R., Oliveira, Alexandre G., Cintra, Dennys E., De Souza, Claudio T., Velloso, Licio A., Carvalheira, Jose B. C., Saad, Mario J. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1249/MSS.0b013e3181e45d08
http://repositorio.unifesp.br/handle/11600/33097
Resumo: DA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. de SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: in the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. in parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy.
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spelling Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese RatsOBESITYACUTE EXERCISEINSULIN SIGNALINGINFLAMMATIONDA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. de SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: in the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. in parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy.State Univ Campinas UNICAMP, Fac Med Sci, Dept Internal Med, Campinas, SP, BrazilUniv São Paulo, Sch Phys Educ & Sport Ribeirao Preto, BR-14049 Ribeirao Preto, SP, BrazilFed Univ São Paulo UNIFESP, Fac Phys Educ, Dept Biosci, Santos, SP, BrazilUniv So Santa Catarina, Hlth Sci Unit, Postgrad Program Hlth Sci, Exercise Biochem & Physiol Lab, Criciuma, SC, BrazilFed Univ São Paulo UNIFESP, Fac Phys Educ, Dept Biosci, Santos, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2006/06961-9FAPESP: 2006/06960-2Lippincott Williams & WilkinsUniversidade Estadual de Campinas (UNICAMP)Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Univ So Santa CatarinaDa Silva, Adelino S. R.Pauli, José Rodrigo [UNIFESP]Ropelle, Eduardo R.Oliveira, Alexandre G.Cintra, Dennys E.De Souza, Claudio T.Velloso, Licio A.Carvalheira, Jose B. C.Saad, Mario J. A.2016-01-24T14:05:42Z2016-01-24T14:05:42Z2010-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2180-2188http://dx.doi.org/10.1249/MSS.0b013e3181e45d08Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 12, p. 2180-2188, 2010.10.1249/MSS.0b013e3181e45d080195-9131http://repositorio.unifesp.br/handle/11600/33097WOS:000284353500005engMedicine and Science in Sports and Exerciseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-08-11T11:48:48Zoai:repositorio.unifesp.br/:11600/33097Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-08-11T11:48:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
title Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
spellingShingle Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
Da Silva, Adelino S. R.
OBESITY
ACUTE EXERCISE
INSULIN SIGNALING
INFLAMMATION
title_short Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
title_full Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
title_fullStr Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
title_full_unstemmed Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
title_sort Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats
author Da Silva, Adelino S. R.
author_facet Da Silva, Adelino S. R.
Pauli, José Rodrigo [UNIFESP]
Ropelle, Eduardo R.
Oliveira, Alexandre G.
Cintra, Dennys E.
De Souza, Claudio T.
Velloso, Licio A.
Carvalheira, Jose B. C.
Saad, Mario J. A.
author_role author
author2 Pauli, José Rodrigo [UNIFESP]
Ropelle, Eduardo R.
Oliveira, Alexandre G.
Cintra, Dennys E.
De Souza, Claudio T.
Velloso, Licio A.
Carvalheira, Jose B. C.
Saad, Mario J. A.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ So Santa Catarina
dc.contributor.author.fl_str_mv Da Silva, Adelino S. R.
Pauli, José Rodrigo [UNIFESP]
Ropelle, Eduardo R.
Oliveira, Alexandre G.
Cintra, Dennys E.
De Souza, Claudio T.
Velloso, Licio A.
Carvalheira, Jose B. C.
Saad, Mario J. A.
dc.subject.por.fl_str_mv OBESITY
ACUTE EXERCISE
INSULIN SIGNALING
INFLAMMATION
topic OBESITY
ACUTE EXERCISE
INSULIN SIGNALING
INFLAMMATION
description DA SILVA, A. S. R., J. R. PAULI, E. R. ROPELLE, A. G. OLIVEIRA, D. E. CINTRA, C. T. de SOUZA, L. A. VELLOSO, J. B. C. CARVALHEIRA, and M. J. A. SAAD. Exercise Intensity, Inflammatory Signaling, and Insulin Resistance in Obese Rats. Med. Sci. Sports Exerc., Vol. 42, No. 12, pp. 2180-2188, 2010. Purpose: To evaluate the effects of intensity of exercise on insulin resistance and the expression of inflammatory proteins in the skeletal muscle of diet-induced obese (DIO) rats after a single bout of exercise. Methods: in the first exercise protocol, the rats swam for two 3-h bouts, separated by a 45-min rest period (with 6 h in duration-DIO + EXE), and in the second protocol, the rats were exercised with 45 min of swimming at 70% of the maximal lactate steady state-MLSS (DIO + MLSS). Results: Our data demonstrated that both protocols of exercise increased insulin sensitivity and increased insulin-stimulated tyrosine phosphorylation of insulin receptor and insulin receptor substrate 1 and serine phosphorylation of protein kinase B in the muscle of DIO rats by the same magnitude. in parallel, both exercise protocols also reduced protein tyrosine phosphatase 1B activity and insulin receptor substrate 1 serine phosphorylation, with concomitant reduction in c-jun N-terminal kinase and I kappa B kinase activities in the muscle of DIO rats in a similar fashion. Conclusions: Thus, our data demonstrate that either exercise protocols with low intensity and high volume or exercise with moderate intensity and low volume represents different strategies to restore insulin sensitivity with the same efficacy.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-01
2016-01-24T14:05:42Z
2016-01-24T14:05:42Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1249/MSS.0b013e3181e45d08
Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 12, p. 2180-2188, 2010.
10.1249/MSS.0b013e3181e45d08
0195-9131
http://repositorio.unifesp.br/handle/11600/33097
WOS:000284353500005
url http://dx.doi.org/10.1249/MSS.0b013e3181e45d08
http://repositorio.unifesp.br/handle/11600/33097
identifier_str_mv Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 42, n. 12, p. 2180-2188, 2010.
10.1249/MSS.0b013e3181e45d08
0195-9131
WOS:000284353500005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medicine and Science in Sports and Exercise
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2180-2188
dc.publisher.none.fl_str_mv Lippincott Williams & Wilkins
publisher.none.fl_str_mv Lippincott Williams & Wilkins
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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