Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Veras |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954 |
Resumo: | Obesity is a chronic multifactorial disease characterized by excess adiposity. Adipose tissue hypertrophy favors lipid deposition in ectopic tissues, such as the liver, which favors the development of the metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by excessive accumulation of lipids in the cytoplasm of hepatocytes (fatty liver). Triglyceride overload in hepatocytes observed in obesity is associated with inflammation and insulin resistance status. Non-pharmacological strategies, such as the practice of physical exercise, seem to be an effective in reducing inflammatory markers and improving insulin sensitivity in obese individuals with MAFLD attenuating hepatocellular steatosis. Thus, this review aims to demonstrate the factors involved in the development of hepatic steatosis, as well as investigate the impact of physical exercise on insulin sensitivity and inflammatory markers in the condition of obesity-associated MAFLD. |
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Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)obesityfatty liverinflammationinsulin resistanceexerciseObesity is a chronic multifactorial disease characterized by excess adiposity. Adipose tissue hypertrophy favors lipid deposition in ectopic tissues, such as the liver, which favors the development of the metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by excessive accumulation of lipids in the cytoplasm of hepatocytes (fatty liver). Triglyceride overload in hepatocytes observed in obesity is associated with inflammation and insulin resistance status. Non-pharmacological strategies, such as the practice of physical exercise, seem to be an effective in reducing inflammatory markers and improving insulin sensitivity in obese individuals with MAFLD attenuating hepatocellular steatosis. Thus, this review aims to demonstrate the factors involved in the development of hepatic steatosis, as well as investigate the impact of physical exercise on insulin sensitivity and inflammatory markers in the condition of obesity-associated MAFLD.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-01-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/5595410.34117/bjdv9n1-053Brazilian Journal of Development; Vol. 9 No. 1 (2023); 735-755Brazilian Journal of Development; Vol. 9 Núm. 1 (2023); 735-755Brazilian Journal of Development; v. 9 n. 1 (2023); 735-7552525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954/41125 Torezani-Sales, SuellemGasparini, Patrícia Vasconcelos FontanaMadureira, Amanda RangelCordeiro, Jóctan PimentelLeopoldo, André SoaresLima-Leopoldo, Ana Paulainfo:eu-repo/semantics/openAccess2023-01-11T14:12:53Zoai:ojs2.ojs.brazilianjournals.com.br:article/55954Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:25:53.736671Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false |
dc.title.none.fl_str_mv |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) |
title |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) |
spellingShingle |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) Torezani-Sales, Suellem obesity fatty liver inflammation insulin resistance exercise |
title_short |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) |
title_full |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) |
title_fullStr |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) |
title_full_unstemmed |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) |
title_sort |
Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD) |
author |
Torezani-Sales, Suellem |
author_facet |
Torezani-Sales, Suellem Gasparini, Patrícia Vasconcelos Fontana Madureira, Amanda Rangel Cordeiro, Jóctan Pimentel Leopoldo, André Soares Lima-Leopoldo, Ana Paula |
author_role |
author |
author2 |
Gasparini, Patrícia Vasconcelos Fontana Madureira, Amanda Rangel Cordeiro, Jóctan Pimentel Leopoldo, André Soares Lima-Leopoldo, Ana Paula |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Torezani-Sales, Suellem Gasparini, Patrícia Vasconcelos Fontana Madureira, Amanda Rangel Cordeiro, Jóctan Pimentel Leopoldo, André Soares Lima-Leopoldo, Ana Paula |
dc.subject.por.fl_str_mv |
obesity fatty liver inflammation insulin resistance exercise |
topic |
obesity fatty liver inflammation insulin resistance exercise |
description |
Obesity is a chronic multifactorial disease characterized by excess adiposity. Adipose tissue hypertrophy favors lipid deposition in ectopic tissues, such as the liver, which favors the development of the metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by excessive accumulation of lipids in the cytoplasm of hepatocytes (fatty liver). Triglyceride overload in hepatocytes observed in obesity is associated with inflammation and insulin resistance status. Non-pharmacological strategies, such as the practice of physical exercise, seem to be an effective in reducing inflammatory markers and improving insulin sensitivity in obese individuals with MAFLD attenuating hepatocellular steatosis. Thus, this review aims to demonstrate the factors involved in the development of hepatic steatosis, as well as investigate the impact of physical exercise on insulin sensitivity and inflammatory markers in the condition of obesity-associated MAFLD. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-03 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954 10.34117/bjdv9n1-053 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954 |
identifier_str_mv |
10.34117/bjdv9n1-053 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954/41125 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Development; Vol. 9 No. 1 (2023); 735-755 Brazilian Journal of Development; Vol. 9 Núm. 1 (2023); 735-755 Brazilian Journal of Development; v. 9 n. 1 (2023); 735-755 2525-8761 reponame:Revista Veras instname:Instituto Superior de Educação Vera Cruz (VeraCruz) instacron:VERACRUZ |
instname_str |
Instituto Superior de Educação Vera Cruz (VeraCruz) |
instacron_str |
VERACRUZ |
institution |
VERACRUZ |
reponame_str |
Revista Veras |
collection |
Revista Veras |
repository.name.fl_str_mv |
Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz) |
repository.mail.fl_str_mv |
||revistaveras@veracruz.edu.br |
_version_ |
1813645624722063360 |