Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)

Detalhes bibliográficos
Autor(a) principal: Torezani-Sales, Suellem
Data de Publicação: 2023
Outros Autores: Gasparini, Patrícia Vasconcelos Fontana, Madureira, Amanda Rangel, Cordeiro, Jóctan Pimentel, Leopoldo, André Soares, Lima-Leopoldo, Ana Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista Veras
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954
Resumo: Obesity is a chronic multifactorial disease characterized by excess adiposity. Adipose tissue hypertrophy favors lipid deposition in ectopic tissues, such as the liver, which favors the development of the metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by excessive accumulation of lipids in the cytoplasm of hepatocytes (fatty liver). Triglyceride overload in hepatocytes observed in obesity is associated with inflammation and insulin resistance status. Non-pharmacological strategies, such as the practice of physical exercise, seem to be an effective in reducing inflammatory markers and improving insulin sensitivity in obese individuals with MAFLD attenuating hepatocellular steatosis. Thus, this review aims to demonstrate the factors involved in the development of hepatic steatosis, as well as investigate the impact of physical exercise on insulin sensitivity and inflammatory markers in the condition of obesity-associated MAFLD.
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spelling Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)obesityfatty liverinflammationinsulin resistanceexerciseObesity is a chronic multifactorial disease characterized by excess adiposity. Adipose tissue hypertrophy favors lipid deposition in ectopic tissues, such as the liver, which favors the development of the metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by excessive accumulation of lipids in the cytoplasm of hepatocytes (fatty liver). Triglyceride overload in hepatocytes observed in obesity is associated with inflammation and insulin resistance status. Non-pharmacological strategies, such as the practice of physical exercise, seem to be an effective in reducing inflammatory markers and improving insulin sensitivity in obese individuals with MAFLD attenuating hepatocellular steatosis. Thus, this review aims to demonstrate the factors involved in the development of hepatic steatosis, as well as investigate the impact of physical exercise on insulin sensitivity and inflammatory markers in the condition of obesity-associated MAFLD.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-01-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/5595410.34117/bjdv9n1-053Brazilian Journal of Development; Vol. 9 No. 1 (2023); 735-755Brazilian Journal of Development; Vol. 9 Núm. 1 (2023); 735-755Brazilian Journal of Development; v. 9 n. 1 (2023); 735-7552525-8761reponame:Revista Verasinstname:Instituto Superior de Educação Vera Cruz (VeraCruz)instacron:VERACRUZenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954/41125 Torezani-Sales, SuellemGasparini, Patrícia Vasconcelos FontanaMadureira, Amanda RangelCordeiro, Jóctan PimentelLeopoldo, André SoaresLima-Leopoldo, Ana Paulainfo:eu-repo/semantics/openAccess2023-01-11T14:12:53Zoai:ojs2.ojs.brazilianjournals.com.br:article/55954Revistahttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/PRIhttp://site.veracruz.edu.br:8087/instituto/revistaveras/index.php/revistaveras/oai||revistaveras@veracruz.edu.br2236-57292236-5729opendoar:2024-10-15T16:25:53.736671Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)false
dc.title.none.fl_str_mv Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
title Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
spellingShingle Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
Torezani-Sales, Suellem
obesity
fatty liver
inflammation
insulin resistance
exercise
title_short Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
title_full Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
title_fullStr Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
title_full_unstemmed Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
title_sort Impact of physical exercise on metabolic dysfunction-associated fatty liver disease (MAFLD)
author Torezani-Sales, Suellem
author_facet Torezani-Sales, Suellem
Gasparini, Patrícia Vasconcelos Fontana
Madureira, Amanda Rangel
Cordeiro, Jóctan Pimentel
Leopoldo, André Soares
Lima-Leopoldo, Ana Paula
author_role author
author2 Gasparini, Patrícia Vasconcelos Fontana
Madureira, Amanda Rangel
Cordeiro, Jóctan Pimentel
Leopoldo, André Soares
Lima-Leopoldo, Ana Paula
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Torezani-Sales, Suellem
Gasparini, Patrícia Vasconcelos Fontana
Madureira, Amanda Rangel
Cordeiro, Jóctan Pimentel
Leopoldo, André Soares
Lima-Leopoldo, Ana Paula
dc.subject.por.fl_str_mv obesity
fatty liver
inflammation
insulin resistance
exercise
topic obesity
fatty liver
inflammation
insulin resistance
exercise
description Obesity is a chronic multifactorial disease characterized by excess adiposity. Adipose tissue hypertrophy favors lipid deposition in ectopic tissues, such as the liver, which favors the development of the metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by excessive accumulation of lipids in the cytoplasm of hepatocytes (fatty liver). Triglyceride overload in hepatocytes observed in obesity is associated with inflammation and insulin resistance status. Non-pharmacological strategies, such as the practice of physical exercise, seem to be an effective in reducing inflammatory markers and improving insulin sensitivity in obese individuals with MAFLD attenuating hepatocellular steatosis. Thus, this review aims to demonstrate the factors involved in the development of hepatic steatosis, as well as investigate the impact of physical exercise on insulin sensitivity and inflammatory markers in the condition of obesity-associated MAFLD.
publishDate 2023
dc.date.none.fl_str_mv 2023-01-03
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954
10.34117/bjdv9n1-053
url https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954
identifier_str_mv 10.34117/bjdv9n1-053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BRJD/article/view/55954/41125
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Development; Vol. 9 No. 1 (2023); 735-755
Brazilian Journal of Development; Vol. 9 Núm. 1 (2023); 735-755
Brazilian Journal of Development; v. 9 n. 1 (2023); 735-755
2525-8761
reponame:Revista Veras
instname:Instituto Superior de Educação Vera Cruz (VeraCruz)
instacron:VERACRUZ
instname_str Instituto Superior de Educação Vera Cruz (VeraCruz)
instacron_str VERACRUZ
institution VERACRUZ
reponame_str Revista Veras
collection Revista Veras
repository.name.fl_str_mv Revista Veras - Instituto Superior de Educação Vera Cruz (VeraCruz)
repository.mail.fl_str_mv ||revistaveras@veracruz.edu.br
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