Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss

Detalhes bibliográficos
Autor(a) principal: Panzan, Michele Quaranta [UNIFESP]
Data de Publicação: 2013
Outros Autores: Mattar, Rosiane [UNIFESP], Maganhin, Carla Cristina [UNIFESP], Simões, Ricardo dos Santos [UNIFESP], Rossi, Alexandre Guilherme Zabeu [UNIFESP], Motta, Eduardo Leme Alves da [UNIFESP], Baracat, Edmund Chada [UNIFESP], Soares Júnior, José Maria [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/35992
http://dx.doi.org/10.1016/j.ejogrb.2012.10.021
Resumo: Objective: To investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. the control group consisted of fertile women.Study design: Endometrial tissue samples from fertile women (n = 25), women with idiopathic infertility (n = 25) and women with idiopathic recurrent pregnancy loss (n = 25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods.Results: Expression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of FASL was similar in all three groups.Conclusion: Disturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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spelling Panzan, Michele Quaranta [UNIFESP]Mattar, Rosiane [UNIFESP]Maganhin, Carla Cristina [UNIFESP]Simões, Ricardo dos Santos [UNIFESP]Rossi, Alexandre Guilherme Zabeu [UNIFESP]Motta, Eduardo Leme Alves da [UNIFESP]Baracat, Edmund Chada [UNIFESP]Soares Júnior, José Maria [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T14:31:17Z2016-01-24T14:31:17Z2013-03-01European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 167, n. 1, p. 47-52, 2013.0301-2115http://repositorio.unifesp.br/handle/11600/35992http://dx.doi.org/10.1016/j.ejogrb.2012.10.021WOS000316429200009.pdf10.1016/j.ejogrb.2012.10.021WOS:000316429200009Objective: To investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. the control group consisted of fertile women.Study design: Endometrial tissue samples from fertile women (n = 25), women with idiopathic infertility (n = 25) and women with idiopathic recurrent pregnancy loss (n = 25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods.Results: Expression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of FASL was similar in all three groups.Conclusion: Disturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Gynaecol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Obstet, São Paulo, BrazilUniv São Paulo, Dept Obstet & Gynaecol, Gynaecol Div, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Gynaecol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Obstet, São Paulo, BrazilFAPESP: 2004/01424-0Web of Science47-52engElsevier B.V.European Journal of Obstetrics & Gynecology and Reproductive Biologyhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessEndometriumFAS-FAS-LBcL-2Cleaved caspase-3Idiopathic infertilityEvaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy lossinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000316429200009.pdfapplication/pdf902590${dspace.ui.url}/bitstream/11600/35992/1/WOS000316429200009.pdfdff89b9acfa991472db2c8c8c138017bMD51open accessTEXTWOS000316429200009.pdf.txtWOS000316429200009.pdf.txtExtracted texttext/plain29879${dspace.ui.url}/bitstream/11600/35992/2/WOS000316429200009.pdf.txt56763a9b6b2686249d8c026449949a71MD52open access11600/359922023-02-15 11:39:37.552open accessoai:repositorio.unifesp.br:11600/35992Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:31:53.286409Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
title Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
spellingShingle Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
Panzan, Michele Quaranta [UNIFESP]
Endometrium
FAS-FAS-L
BcL-2
Cleaved caspase-3
Idiopathic infertility
title_short Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
title_full Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
title_fullStr Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
title_full_unstemmed Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
title_sort Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
author Panzan, Michele Quaranta [UNIFESP]
author_facet Panzan, Michele Quaranta [UNIFESP]
Mattar, Rosiane [UNIFESP]
Maganhin, Carla Cristina [UNIFESP]
Simões, Ricardo dos Santos [UNIFESP]
Rossi, Alexandre Guilherme Zabeu [UNIFESP]
Motta, Eduardo Leme Alves da [UNIFESP]
Baracat, Edmund Chada [UNIFESP]
Soares Júnior, José Maria [UNIFESP]
author_role author
author2 Mattar, Rosiane [UNIFESP]
Maganhin, Carla Cristina [UNIFESP]
Simões, Ricardo dos Santos [UNIFESP]
Rossi, Alexandre Guilherme Zabeu [UNIFESP]
Motta, Eduardo Leme Alves da [UNIFESP]
Baracat, Edmund Chada [UNIFESP]
Soares Júnior, José Maria [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Panzan, Michele Quaranta [UNIFESP]
Mattar, Rosiane [UNIFESP]
Maganhin, Carla Cristina [UNIFESP]
Simões, Ricardo dos Santos [UNIFESP]
Rossi, Alexandre Guilherme Zabeu [UNIFESP]
Motta, Eduardo Leme Alves da [UNIFESP]
Baracat, Edmund Chada [UNIFESP]
Soares Júnior, José Maria [UNIFESP]
dc.subject.eng.fl_str_mv Endometrium
FAS-FAS-L
BcL-2
Cleaved caspase-3
Idiopathic infertility
topic Endometrium
FAS-FAS-L
BcL-2
Cleaved caspase-3
Idiopathic infertility
description Objective: To investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. the control group consisted of fertile women.Study design: Endometrial tissue samples from fertile women (n = 25), women with idiopathic infertility (n = 25) and women with idiopathic recurrent pregnancy loss (n = 25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods.Results: Expression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of FASL was similar in all three groups.Conclusion: Disturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
publishDate 2013
dc.date.issued.fl_str_mv 2013-03-01
dc.date.accessioned.fl_str_mv 2016-01-24T14:31:17Z
dc.date.available.fl_str_mv 2016-01-24T14:31:17Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 167, n. 1, p. 47-52, 2013.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/35992
http://dx.doi.org/10.1016/j.ejogrb.2012.10.021
dc.identifier.issn.none.fl_str_mv 0301-2115
dc.identifier.file.none.fl_str_mv WOS000316429200009.pdf
dc.identifier.doi.none.fl_str_mv 10.1016/j.ejogrb.2012.10.021
dc.identifier.wos.none.fl_str_mv WOS:000316429200009
identifier_str_mv European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 167, n. 1, p. 47-52, 2013.
0301-2115
WOS000316429200009.pdf
10.1016/j.ejogrb.2012.10.021
WOS:000316429200009
url http://repositorio.unifesp.br/handle/11600/35992
http://dx.doi.org/10.1016/j.ejogrb.2012.10.021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv European Journal of Obstetrics & Gynecology and Reproductive Biology
dc.rights.driver.fl_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 47-52
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
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instname:Universidade Federal de São Paulo (UNIFESP)
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reponame_str Repositório Institucional da UNIFESP
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