Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35992 http://dx.doi.org/10.1016/j.ejogrb.2012.10.021 |
Resumo: | Objective: To investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. the control group consisted of fertile women.Study design: Endometrial tissue samples from fertile women (n = 25), women with idiopathic infertility (n = 25) and women with idiopathic recurrent pregnancy loss (n = 25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods.Results: Expression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of FASL was similar in all three groups.Conclusion: Disturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
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Panzan, Michele Quaranta [UNIFESP]Mattar, Rosiane [UNIFESP]Maganhin, Carla Cristina [UNIFESP]Simões, Ricardo dos Santos [UNIFESP]Rossi, Alexandre Guilherme Zabeu [UNIFESP]Motta, Eduardo Leme Alves da [UNIFESP]Baracat, Edmund Chada [UNIFESP]Soares Júnior, José Maria [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2016-01-24T14:31:17Z2016-01-24T14:31:17Z2013-03-01European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 167, n. 1, p. 47-52, 2013.0301-2115http://repositorio.unifesp.br/handle/11600/35992http://dx.doi.org/10.1016/j.ejogrb.2012.10.021WOS000316429200009.pdf10.1016/j.ejogrb.2012.10.021WOS:000316429200009Objective: To investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. the control group consisted of fertile women.Study design: Endometrial tissue samples from fertile women (n = 25), women with idiopathic infertility (n = 25) and women with idiopathic recurrent pregnancy loss (n = 25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods.Results: Expression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of FASL was similar in all three groups.Conclusion: Disturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo, Dept Gynaecol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Obstet, São Paulo, BrazilUniv São Paulo, Dept Obstet & Gynaecol, Gynaecol Div, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Gynaecol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Obstet, São Paulo, BrazilFAPESP: 2004/01424-0Web of Science47-52engElsevier B.V.European Journal of Obstetrics & Gynecology and Reproductive Biologyhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessEndometriumFAS-FAS-LBcL-2Cleaved caspase-3Idiopathic infertilityEvaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy lossinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000316429200009.pdfapplication/pdf902590${dspace.ui.url}/bitstream/11600/35992/1/WOS000316429200009.pdfdff89b9acfa991472db2c8c8c138017bMD51open accessTEXTWOS000316429200009.pdf.txtWOS000316429200009.pdf.txtExtracted texttext/plain29879${dspace.ui.url}/bitstream/11600/35992/2/WOS000316429200009.pdf.txt56763a9b6b2686249d8c026449949a71MD52open access11600/359922023-02-15 11:39:37.552open accessoai:repositorio.unifesp.br:11600/35992Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-02-15T14:39:37Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss |
title |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss |
spellingShingle |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss Panzan, Michele Quaranta [UNIFESP] Endometrium FAS-FAS-L BcL-2 Cleaved caspase-3 Idiopathic infertility |
title_short |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss |
title_full |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss |
title_fullStr |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss |
title_full_unstemmed |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss |
title_sort |
Evaluation of FAS and caspase-3 in the endometrial tissue of patients with idiopathic infertility and recurrent pregnancy loss |
author |
Panzan, Michele Quaranta [UNIFESP] |
author_facet |
Panzan, Michele Quaranta [UNIFESP] Mattar, Rosiane [UNIFESP] Maganhin, Carla Cristina [UNIFESP] Simões, Ricardo dos Santos [UNIFESP] Rossi, Alexandre Guilherme Zabeu [UNIFESP] Motta, Eduardo Leme Alves da [UNIFESP] Baracat, Edmund Chada [UNIFESP] Soares Júnior, José Maria [UNIFESP] |
author_role |
author |
author2 |
Mattar, Rosiane [UNIFESP] Maganhin, Carla Cristina [UNIFESP] Simões, Ricardo dos Santos [UNIFESP] Rossi, Alexandre Guilherme Zabeu [UNIFESP] Motta, Eduardo Leme Alves da [UNIFESP] Baracat, Edmund Chada [UNIFESP] Soares Júnior, José Maria [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Panzan, Michele Quaranta [UNIFESP] Mattar, Rosiane [UNIFESP] Maganhin, Carla Cristina [UNIFESP] Simões, Ricardo dos Santos [UNIFESP] Rossi, Alexandre Guilherme Zabeu [UNIFESP] Motta, Eduardo Leme Alves da [UNIFESP] Baracat, Edmund Chada [UNIFESP] Soares Júnior, José Maria [UNIFESP] |
dc.subject.eng.fl_str_mv |
Endometrium FAS-FAS-L BcL-2 Cleaved caspase-3 Idiopathic infertility |
topic |
Endometrium FAS-FAS-L BcL-2 Cleaved caspase-3 Idiopathic infertility |
description |
Objective: To investigate expression of BcL-2, FAS, FAS ligand (FASL) and cleaved caspase-3 in the endometrial tissue of women with idiopathic infertility (with two consecutive failed cycles of in vitro fertilization) and women with idiopathic recurrent pregnancy loss. the control group consisted of fertile women.Study design: Endometrial tissue samples from fertile women (n = 25), women with idiopathic infertility (n = 25) and women with idiopathic recurrent pregnancy loss (n = 25) were collected on the seventh or eighth postovulatory day of their menstrual cycles for evaluation. Expression of BcL-2, FAS, FASL and cleaved caspase-3 was assessed using immunohistochemical methods.Results: Expression of BcL-2 and FAS was significantly higher and lower, respectively, in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of cleaved caspase-3 was significantly lower in the women with idiopathic infertility than in the other groups (p < 0.01). Expression of FASL was similar in all three groups.Conclusion: Disturbances in endometrial apoptosis may be a contributing factor in patients with idiopathic infertility and recurrent pregnancy loss. (C) 2012 Elsevier Ireland Ltd. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:17Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:17Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 167, n. 1, p. 47-52, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35992 http://dx.doi.org/10.1016/j.ejogrb.2012.10.021 |
dc.identifier.issn.none.fl_str_mv |
0301-2115 |
dc.identifier.file.none.fl_str_mv |
WOS000316429200009.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.ejogrb.2012.10.021 |
dc.identifier.wos.none.fl_str_mv |
WOS:000316429200009 |
identifier_str_mv |
European Journal of Obstetrics & Gynecology and Reproductive Biology. Amsterdam: Elsevier B.V., v. 167, n. 1, p. 47-52, 2013. 0301-2115 WOS000316429200009.pdf 10.1016/j.ejogrb.2012.10.021 WOS:000316429200009 |
url |
http://repositorio.unifesp.br/handle/11600/35992 http://dx.doi.org/10.1016/j.ejogrb.2012.10.021 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
European Journal of Obstetrics & Gynecology and Reproductive Biology |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
47-52 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
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