Triple therapy with clarithromycin, amoxicillin and omeprazole for Helicobacter pylori eradication in children and adolescents

• Autor(a) principal: Kawakami, Elisabete [UNIFESP]
• Data de Publicação: 2001
• Outros Autores: Ogata, Silvio Kazuo [UNIFESP], Miranda, Áurea Cristina Portorreal [UNIFESP], Magni, Ana Maria, Pardo, Mário Luís E. [UNIFESP], Patricio, Francy Reis da Silva [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/0013000012mxc
• DOI: 10.1590/S0004-28032001000300011
• Texto Completo: http://dx.doi.org/10.1590/S0004-28032001000300011; http://repositorio.unifesp.br/handle/11600/1235
• topic: Clarithromycin; Amoxicillin; Omeprazole; Helicobacter infections; Child; Adolescence; Claritromicina; Amoxicilina; Omeprazol; Infecções por helicobacter; Criança; Adolescência

Background Helicobacter pylori infection presents high prevalence in developing countries, but there are few pediatric assays evaluating antimicrobial treatment. Objective - The aim of this study was to investigate Helicobacter pylori eradication rate using a short regimen (7 and 10 days) of triple therapy with clarithromycin, amoxicillin and omeprazole. Patients and methods - Twenty-five Hp positive patients who presented severe epigastralgia, were submitted to antimicrobial treatment with amoxicillin (50 mg/kg/day - maximum dose 1g bid), clarithromycin (30 mg/kg/day - maximum dose 500 mg bid) and omeprazole (0.6 mg/kg/day - maximum dose 20 mg bid) during 7 or 10 days. After 2 months, clinical symptoms were evaluated and gastric biopsies were taken to test Hp eradication. Results - Overall eradication rate was achieved in 16/25 patients (64% - IC(95%) = 45-83%), in 11/15 (73% - IC(95%) = 51-95%) patients who used 10 days therapy course and in 5/10 (50% - IC(95%) = 19-81%) who used 7 days therapy course. Eradication drugs were well accepted and adverse effects were reported in two patients (8%). Conclusions - This triple therapy regimen had moderate efficacy (64%). The data suggests that 10 days therapy course achieves better eradication rate (73%) than 7 days course (50%) to treat Hp infection in our population.