Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress

Detalhes bibliográficos
Autor(a) principal: Meneghini, Adriano
Data de Publicação: 2009
Outros Autores: Ferreira, Celso [UNIFESP], Abreu, Luiz Carlos de, Valenti, Vitor Engrácia [UNIFESP], Ferreira, Marcelo, F. Filho, Celso, Murad, Neif
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1807-59322009000900014
http://repositorio.unifesp.br/handle/11600/4806
Resumo: OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress.
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spelling Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stressMemantineCardiac myocytesCardiotonic agentsCell nucleus structuresHeartOBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress.Faculdade de Medicina do ABC Departamento de Clínica MédicaUniversidade Federal de São Paulo (UNIFESP) Departamento de MedicinaUniversidade de São Paulo Departamento de Saúde PúblicaUNIFESP, Depto. de MedicinaSciELOFaculdade de Medicina / USPFaculdade de Medicina do ABC Departamento de Clínica MédicaUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Meneghini, AdrianoFerreira, Celso [UNIFESP]Abreu, Luiz Carlos deValenti, Vitor Engrácia [UNIFESP]Ferreira, MarceloF. Filho, CelsoMurad, Neif2015-06-14T13:38:59Z2015-06-14T13:38:59Z2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion921-926application/pdfhttp://dx.doi.org/10.1590/S1807-59322009000900014Clinics. Faculdade de Medicina / USP, v. 64, n. 9, p. 921-926, 2009.10.1590/S1807-59322009000900014S1807-59322009000900014.pdf1807-5932S1807-59322009000900014http://repositorio.unifesp.br/handle/11600/4806WOS:000270232700014engClinicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T10:07:54Zoai:repositorio.unifesp.br/:11600/4806Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T10:07:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
title Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
spellingShingle Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
Meneghini, Adriano
Memantine
Cardiac myocytes
Cardiotonic agents
Cell nucleus structures
Heart
title_short Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
title_full Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
title_fullStr Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
title_full_unstemmed Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
title_sort Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
author Meneghini, Adriano
author_facet Meneghini, Adriano
Ferreira, Celso [UNIFESP]
Abreu, Luiz Carlos de
Valenti, Vitor Engrácia [UNIFESP]
Ferreira, Marcelo
F. Filho, Celso
Murad, Neif
author_role author
author2 Ferreira, Celso [UNIFESP]
Abreu, Luiz Carlos de
Valenti, Vitor Engrácia [UNIFESP]
Ferreira, Marcelo
F. Filho, Celso
Murad, Neif
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Faculdade de Medicina do ABC Departamento de Clínica Médica
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Meneghini, Adriano
Ferreira, Celso [UNIFESP]
Abreu, Luiz Carlos de
Valenti, Vitor Engrácia [UNIFESP]
Ferreira, Marcelo
F. Filho, Celso
Murad, Neif
dc.subject.por.fl_str_mv Memantine
Cardiac myocytes
Cardiotonic agents
Cell nucleus structures
Heart
topic Memantine
Cardiac myocytes
Cardiotonic agents
Cell nucleus structures
Heart
description OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress.
publishDate 2009
dc.date.none.fl_str_mv 2009-01-01
2015-06-14T13:38:59Z
2015-06-14T13:38:59Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1807-59322009000900014
Clinics. Faculdade de Medicina / USP, v. 64, n. 9, p. 921-926, 2009.
10.1590/S1807-59322009000900014
S1807-59322009000900014.pdf
1807-5932
S1807-59322009000900014
http://repositorio.unifesp.br/handle/11600/4806
WOS:000270232700014
url http://dx.doi.org/10.1590/S1807-59322009000900014
http://repositorio.unifesp.br/handle/11600/4806
identifier_str_mv Clinics. Faculdade de Medicina / USP, v. 64, n. 9, p. 921-926, 2009.
10.1590/S1807-59322009000900014
S1807-59322009000900014.pdf
1807-5932
S1807-59322009000900014
WOS:000270232700014
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 921-926
application/pdf
dc.publisher.none.fl_str_mv Faculdade de Medicina / USP
publisher.none.fl_str_mv Faculdade de Medicina / USP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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