Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1807-59322009000900014 http://repositorio.unifesp.br/handle/11600/4806 |
Resumo: | OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress. |
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Repositório Institucional da UNIFESP |
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Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stressMemantineCardiac myocytesCardiotonic agentsCell nucleus structuresHeartOBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress.Faculdade de Medicina do ABC Departamento de Clínica MédicaUniversidade Federal de São Paulo (UNIFESP) Departamento de MedicinaUniversidade de São Paulo Departamento de Saúde PúblicaUNIFESP, Depto. de MedicinaSciELOFaculdade de Medicina / USPFaculdade de Medicina do ABC Departamento de Clínica MédicaUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Meneghini, AdrianoFerreira, Celso [UNIFESP]Abreu, Luiz Carlos deValenti, Vitor Engrácia [UNIFESP]Ferreira, MarceloF. Filho, CelsoMurad, Neif2015-06-14T13:38:59Z2015-06-14T13:38:59Z2009-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion921-926application/pdfhttp://dx.doi.org/10.1590/S1807-59322009000900014Clinics. Faculdade de Medicina / USP, v. 64, n. 9, p. 921-926, 2009.10.1590/S1807-59322009000900014S1807-59322009000900014.pdf1807-5932S1807-59322009000900014http://repositorio.unifesp.br/handle/11600/4806WOS:000270232700014engClinicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T10:07:54Zoai:repositorio.unifesp.br/:11600/4806Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T10:07:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
spellingShingle |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress Meneghini, Adriano Memantine Cardiac myocytes Cardiotonic agents Cell nucleus structures Heart |
title_short |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_full |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_fullStr |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_full_unstemmed |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
title_sort |
Memantine prevents cardiomyocytes nuclear size reduction in the left ventricle of rats exposed to cold stress |
author |
Meneghini, Adriano |
author_facet |
Meneghini, Adriano Ferreira, Celso [UNIFESP] Abreu, Luiz Carlos de Valenti, Vitor Engrácia [UNIFESP] Ferreira, Marcelo F. Filho, Celso Murad, Neif |
author_role |
author |
author2 |
Ferreira, Celso [UNIFESP] Abreu, Luiz Carlos de Valenti, Vitor Engrácia [UNIFESP] Ferreira, Marcelo F. Filho, Celso Murad, Neif |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina do ABC Departamento de Clínica Médica Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Meneghini, Adriano Ferreira, Celso [UNIFESP] Abreu, Luiz Carlos de Valenti, Vitor Engrácia [UNIFESP] Ferreira, Marcelo F. Filho, Celso Murad, Neif |
dc.subject.por.fl_str_mv |
Memantine Cardiac myocytes Cardiotonic agents Cell nucleus structures Heart |
topic |
Memantine Cardiac myocytes Cardiotonic agents Cell nucleus structures Heart |
description |
OBJECTIVES: Memantine is an N-methyl-d-aspartate (NMDA) glutamate receptor antagonist used to treat Alzheimer's disease. Previous studies have suggested that receptor blockers act as neuroprotective agents; however, no study has specifically investigated the impact that these drugs have on the heart. We sought to evaluate the effects of memantine on nuclear size reduction in cardiac cells exposed to cold stress. METHOD: We used male EPM-Wistar rats (n=40) divided into 4 groups: 1) Matched control (CON); 2) Memantine-treated rats (MEM); 3) Rats undergoing induced hypothermia (IH) and 4) Rats undergoing induced hypothermia that were also treated with memantine (IHM). Animals in the MEM and IHM groups were treated by oral gavage administration of 20 mg/kg/day memantine over an eight-day period. Animals in the IH and IHM groups were submitted to 4 hours of hypothermia in a controlled environment with a temperature of - 8ºC on the last day of the study. RESULTS: The MEM group had the largest cardiomyocyte nuclear size (151 ± 3.5 μm³ vs. CON: 142 ± 2.3 μm³; p<0.05), while the IH group had the smallest mean value of nuclear size. The nuclear size of the IHM group was preserved (125 ± 2.9 μm³) compared to the IH group (108 ± 1.7 μm³; p<0.05). CONCLUSION: Memantine prevented the nuclear size reduction of cardiomyocytes in rats exposed to cold stress. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2015-06-14T13:38:59Z 2015-06-14T13:38:59Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1807-59322009000900014 Clinics. Faculdade de Medicina / USP, v. 64, n. 9, p. 921-926, 2009. 10.1590/S1807-59322009000900014 S1807-59322009000900014.pdf 1807-5932 S1807-59322009000900014 http://repositorio.unifesp.br/handle/11600/4806 WOS:000270232700014 |
url |
http://dx.doi.org/10.1590/S1807-59322009000900014 http://repositorio.unifesp.br/handle/11600/4806 |
identifier_str_mv |
Clinics. Faculdade de Medicina / USP, v. 64, n. 9, p. 921-926, 2009. 10.1590/S1807-59322009000900014 S1807-59322009000900014.pdf 1807-5932 S1807-59322009000900014 WOS:000270232700014 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
921-926 application/pdf |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / USP |
publisher.none.fl_str_mv |
Faculdade de Medicina / USP |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268417333526528 |