Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/43239 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878009/ |
Resumo: | Osteoarthritis (OA) of the metacarpophalangeal joint is the most common articular disease in polo ponies leading to early retirement. A biomarker that would discriminate between pathological and physiological changes secondary to exercise could be helpful in OA prevention. The aim of this study was to investigate the effects of polo training on synovial fluid biomarkers of inflammation and cartilage turnover in polo ponies of different skill levels. Synovial fluid samples were collected from metacarpophalangeal joints of polo ponies before and during the polo season (320 d). Nucleated cells, soluble protein, prostaglandin E-2 (PGE(2)), glycosaminoglycans (GAG), and urea were measured. The main synovial fluid GAG are chondroitin sulphate (CS, similar to 25 mu g/mL) and hyaluronic acid (HA, similar to 400 mu g/mL). After a polo match, a transitory increase in protein and PGE(2), but not CS and HA, occurred (expressed as urea ratio), returning to basal levels in 24 h. During the polo season, the number of synovial fluid nucleated cells was always in the normal range. Increases in protein and HA occurred during the initial 40 to 80 d, returning to basal levels afterwards. In contrast, in polo prospects the concentration of CS steadily increased during the season. Long-term follow-up revealed that the synovial fluid CS was significantly higher in polo ponies that developed joint diseases within 24 months following our study. In conclusion, CS seems to be an early marker of articular cartilage damage. |
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Baccarin, Raquel Yvonne ArantesRasera, LucianeMachado, Thais S. L.Michelacci, Yara Maria [UNIFESP]Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2018-06-15T16:39:13Z2018-06-15T16:39:13Z2014-01-01Canadian Journal Of Veterinary Research-revue Canadienne De Recherche Veterinaire. Ottawa: Canadian Vet Med Assoc, v. 78, n. 1, p. 50-60, 2014.0830-9000http://repositorio.unifesp.br/11600/43239https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878009/WOS:000331367700008Osteoarthritis (OA) of the metacarpophalangeal joint is the most common articular disease in polo ponies leading to early retirement. A biomarker that would discriminate between pathological and physiological changes secondary to exercise could be helpful in OA prevention. The aim of this study was to investigate the effects of polo training on synovial fluid biomarkers of inflammation and cartilage turnover in polo ponies of different skill levels. Synovial fluid samples were collected from metacarpophalangeal joints of polo ponies before and during the polo season (320 d). Nucleated cells, soluble protein, prostaglandin E-2 (PGE(2)), glycosaminoglycans (GAG), and urea were measured. The main synovial fluid GAG are chondroitin sulphate (CS, similar to 25 mu g/mL) and hyaluronic acid (HA, similar to 400 mu g/mL). After a polo match, a transitory increase in protein and PGE(2), but not CS and HA, occurred (expressed as urea ratio), returning to basal levels in 24 h. During the polo season, the number of synovial fluid nucleated cells was always in the normal range. Increases in protein and HA occurred during the initial 40 to 80 d, returning to basal levels afterwards. In contrast, in polo prospects the concentration of CS steadily increased during the season. Long-term follow-up revealed that the synovial fluid CS was significantly higher in polo ponies that developed joint diseases within 24 months following our study. In conclusion, CS seems to be an early marker of articular cartilage damage.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Sao Paulo, Fac Med Vet & Zootecnia, Dept Clin Med, BR-09500900 Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Bioquim, Sao Paulo, BrazilUniv Fed Sao Paulo UNIFESP, Escola Paulista Med, Dept Bioquim, Sao Paulo, BrazilWeb of Science50-60engCanadian Vet Med AssocCanadian Journal Of Veterinary Research-revue Canadienne De Recherche VeterinaireRelevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony jointsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/432392021-09-29 14:55:25.258metadata only accessoai:repositorio.unifesp.br:11600/43239Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-29T17:55:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints |
title |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints |
spellingShingle |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints Baccarin, Raquel Yvonne Arantes |
title_short |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints |
title_full |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints |
title_fullStr |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints |
title_full_unstemmed |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints |
title_sort |
Relevance of synovial fluid chondroitin sulphate as a biomarker to monitor polo pony joints |
author |
Baccarin, Raquel Yvonne Arantes |
author_facet |
Baccarin, Raquel Yvonne Arantes Rasera, Luciane Machado, Thais S. L. Michelacci, Yara Maria [UNIFESP] |
author_role |
author |
author2 |
Rasera, Luciane Machado, Thais S. L. Michelacci, Yara Maria [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Baccarin, Raquel Yvonne Arantes Rasera, Luciane Machado, Thais S. L. Michelacci, Yara Maria [UNIFESP] |
description |
Osteoarthritis (OA) of the metacarpophalangeal joint is the most common articular disease in polo ponies leading to early retirement. A biomarker that would discriminate between pathological and physiological changes secondary to exercise could be helpful in OA prevention. The aim of this study was to investigate the effects of polo training on synovial fluid biomarkers of inflammation and cartilage turnover in polo ponies of different skill levels. Synovial fluid samples were collected from metacarpophalangeal joints of polo ponies before and during the polo season (320 d). Nucleated cells, soluble protein, prostaglandin E-2 (PGE(2)), glycosaminoglycans (GAG), and urea were measured. The main synovial fluid GAG are chondroitin sulphate (CS, similar to 25 mu g/mL) and hyaluronic acid (HA, similar to 400 mu g/mL). After a polo match, a transitory increase in protein and PGE(2), but not CS and HA, occurred (expressed as urea ratio), returning to basal levels in 24 h. During the polo season, the number of synovial fluid nucleated cells was always in the normal range. Increases in protein and HA occurred during the initial 40 to 80 d, returning to basal levels afterwards. In contrast, in polo prospects the concentration of CS steadily increased during the season. Long-term follow-up revealed that the synovial fluid CS was significantly higher in polo ponies that developed joint diseases within 24 months following our study. In conclusion, CS seems to be an early marker of articular cartilage damage. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T16:39:13Z |
dc.date.available.fl_str_mv |
2018-06-15T16:39:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Canadian Journal Of Veterinary Research-revue Canadienne De Recherche Veterinaire. Ottawa: Canadian Vet Med Assoc, v. 78, n. 1, p. 50-60, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/43239 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878009/ |
dc.identifier.issn.none.fl_str_mv |
0830-9000 |
dc.identifier.wos.none.fl_str_mv |
WOS:000331367700008 |
identifier_str_mv |
Canadian Journal Of Veterinary Research-revue Canadienne De Recherche Veterinaire. Ottawa: Canadian Vet Med Assoc, v. 78, n. 1, p. 50-60, 2014. 0830-9000 WOS:000331367700008 |
url |
http://repositorio.unifesp.br/11600/43239 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3878009/ |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Canadian Journal Of Veterinary Research-revue Canadienne De Recherche Veterinaire |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
50-60 |
dc.publisher.none.fl_str_mv |
Canadian Vet Med Assoc |
publisher.none.fl_str_mv |
Canadian Vet Med Assoc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764113257955328 |