Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

• Autor(a) principal: Andersen, Monica L. [UNIFESP]
• Data de Publicação: 2011
• Outros Autores: Alvarenga, Tathiana A. [UNIFESP], Mazzotti, Diego R. [UNIFESP], Guindalini, Camila [UNIFESP], Pellegrino, Renata [UNIFESP], Barrueco, Karina F. [UNIFESP], Santos-Silva, Rogerio [UNIFESP], Bittencourt, Lia R. [UNIFESP], Tufik, Sergio [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.fertnstert.2010.10.012; http://repositorio.unifesp.br/handle/11600/33371
• topic: Sleep; progesterone; PROGINS; erectile dysfunction; prolactin; testosterone; erection

Objective: To evaluate a potential association among the hormonal profile, PROGINS polymorphism, and erectile dysfunction (ED) complaints in a large population-based sample in São Paulo, Brazil.Design: Population-based questionnaire study.Setting: Interviews, sleep recording, and blood sample were conducted in a sleep institute.Patient(s): the total study participants included 467 men.Intervention(s): General information was obtained through interviews, and a blood sample was collected for hormone levels, DNA extraction, and PROGINS genotyping.Main Outcome Measure(s): the effect of progesterone and the PROGINS polymorphism on the risk of developing ED were measured by questionnaire and blood sample.Result(s): Progesterone, prolactin, testosterone, and estradiol levels did not differ between the genotype groups (T1/T1 and T1/T2+T2/T2). No significant genotypic or allelic differences were found between individuals with ED complaints and controls. Multivariate logistic regression analyses including age, body mass index, hypertension, diabetes, apnea-hypopnea index, and genetic ancestry estimation, as well as the PROGINS polymorphism, confirmed the lack of association between the T2 allele carriers and the risk of ED(odds ratio = 0.80; 95% confidence interval = 0.40-1.62).Conclusion(s): This is the first study to demonstrate the genotypic and allelic frequencies of the PROGINS polymorphism in a large population-based sample of men. the results do not support a direct role for the PROGINS polymorphism in the risk of developing ED; however, further examination of other variants within PR gene will be necessary to completely rule out an effect. (Fertil Steril (R) 2011;95:621-4. (C) 2011 by American Society for Reproductive Medicine.)