Optical Coherence Tomography of Retinal Lesions in Infants With Congenital Zika Syndrome

• Autor(a) principal: Ventura, Camila Vieira [UNIFESP]
• Data de Publicação: 2016
• Outros Autores: Ventura, Liana O., Bravo-Filho, Vasco, Martins, Thayze T., Berrocal, Audina M., Gois, Adriana L., Dias, Joao Rafael de Oliveira [UNIFESP], Araujo, Leandro, Escariao, Paulo, van der Linden, Vanessa, Belfort, Rubens Junior [UNIFESP], Maia, Mauricio [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1001/jamaophthalmol.2016.4283; https://repositorio.unifesp.br/handle/11600/56624

IMPORTANCE Zika virus (ZIKV) can cause severe changes in the retina and choroid that may result in marked visual impairment in infants with congenital Zika syndrome (CZS), the term created for a variety of anomalies associated with intrauterine ZIKV infection. OBJECTIVE To evaluate the affected retinal layers in infants with CZS and associated retinal abnormalities using optical coherence tomography (OCT). DESIGN, SETTING, AND PARTICIPANTS This cross-sectional, consecutive case series included 8 infants (age range, 3.0-5.1 months) with CZS. Optical coherence tomographic images were obtained in the affected eyes of 7 infants with CZS who had undergone previous ophthalmologic examinations on March 17, 2016, and in 1 infant on January 1, 2016. An IgM antibody-capture enzyme-linked immunosorbent assay for ZIKV was performed on the cerebrospinal fluid samples of 7 of the 8 infants (88%), and other congenital infections were ruled out. MAIN OUTCOMES AND MEASURES Observation of retinal and choroidal findings in the OCT images. RESULTS Among the 8 infants included in the study (3 male