Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/34719 https://dx.doi.org/10.1186/1477-7827-10-22 |
Resumo: | Background: Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also used for the treatments of psychiatric disorders and neuropathic pain. the CBZ utilization has been associated with male reproductive damage, including hormonal alterations, sexual dysfunction and reduction of sperm quality. the wide and long-term use of the CBZ is a common schedule in children and adolescents and alters the testosterone level in adult rats and humans. the objective of this work was to evaluate the CBZ side effects on the ventral prostate of rats from pre-puberty to sexual maturation, since the prostate is an androgen-dependent organ.Methods: Twenty three day-old male albino Wistar rats received CBZ diluted in propylene glycol (20 mg/Kg/i.p via). the treatment lasted 20, 40 and 70 days, according to the different stages of the rat sexual maturation. At the end of each treatment period, ventral prostates were removed and histologically processed. the prostate sections were submitted to the histopathological, morphological and stereological analyses using image analysis system.Results: Reductions of the glandular epithelium, glandular lumen and fibromuscular stroma volume of the ventral prostate were observed in adult rats treated with CBZ since the weaning. Triggering and degranulation of mast cells were observed in the fibromuscular stroma of prepubertal and pubertal CBZ treated rats.Conclusions: the results suggest a direct effect of the CBZ on rat ventral prostate, evidenced by increase of mast cell and macrophage populations during pre-puberty and puberty causing a ventral prostate accentuated damage in the adult phase. |
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Oliva, Samara Urban de [UNIFESP]Scarano, Wellerson RodrigoOkada, Fatima Kazue [UNIFESP]Miraglia, Sandra Maria [UNIFESP]Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:26:59Z2016-01-24T14:26:59Z2012-03-25Reproductive Biology and Endocrinology. London: Biomed Central Ltd, v. 10, 15 p., 2012.1477-7827https://repositorio.unifesp.br/handle/11600/34719https://dx.doi.org/10.1186/1477-7827-10-22WOS000303869100001.pdf10.1186/1477-7827-10-22WOS:000303869100001Background: Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also used for the treatments of psychiatric disorders and neuropathic pain. the CBZ utilization has been associated with male reproductive damage, including hormonal alterations, sexual dysfunction and reduction of sperm quality. the wide and long-term use of the CBZ is a common schedule in children and adolescents and alters the testosterone level in adult rats and humans. the objective of this work was to evaluate the CBZ side effects on the ventral prostate of rats from pre-puberty to sexual maturation, since the prostate is an androgen-dependent organ.Methods: Twenty three day-old male albino Wistar rats received CBZ diluted in propylene glycol (20 mg/Kg/i.p via). the treatment lasted 20, 40 and 70 days, according to the different stages of the rat sexual maturation. At the end of each treatment period, ventral prostates were removed and histologically processed. the prostate sections were submitted to the histopathological, morphological and stereological analyses using image analysis system.Results: Reductions of the glandular epithelium, glandular lumen and fibromuscular stroma volume of the ventral prostate were observed in adult rats treated with CBZ since the weaning. Triggering and degranulation of mast cells were observed in the fibromuscular stroma of prepubertal and pubertal CBZ treated rats.Conclusions: the results suggest a direct effect of the CBZ on rat ventral prostate, evidenced by increase of mast cell and macrophage populations during pre-puberty and puberty causing a ventral prostate accentuated damage in the adult phase.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)São Paulo State Univ UNESP, Dept Morphol, Botucatu, SP, BrazilFed Univ São Paulo UNIFESP, Dev Biol Lab, Dept Morphol & Genet, São Paulo, BrazilFed Univ São Paulo UNIFESP, Dev Biol Lab, Dept Morphol & Genet, São Paulo, BrazilWeb of Science15engBiomed Central LtdReproductive Biology and EndocrinologyCarbamazepineVentral prostateMast cellsStereologyHarmful effects of carbamazepine on the postnatal development of the rat ventral prostateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/347192023-06-22 17:56:50.02metadata only accessoai:repositorio.unifesp.br:11600/34719Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-22T20:56:50Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
spellingShingle |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate Oliva, Samara Urban de [UNIFESP] Carbamazepine Ventral prostate Mast cells Stereology |
title_short |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_full |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_fullStr |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_full_unstemmed |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
title_sort |
Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate |
author |
Oliva, Samara Urban de [UNIFESP] |
author_facet |
Oliva, Samara Urban de [UNIFESP] Scarano, Wellerson Rodrigo Okada, Fatima Kazue [UNIFESP] Miraglia, Sandra Maria [UNIFESP] |
author_role |
author |
author2 |
Scarano, Wellerson Rodrigo Okada, Fatima Kazue [UNIFESP] Miraglia, Sandra Maria [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Oliva, Samara Urban de [UNIFESP] Scarano, Wellerson Rodrigo Okada, Fatima Kazue [UNIFESP] Miraglia, Sandra Maria [UNIFESP] |
dc.subject.eng.fl_str_mv |
Carbamazepine Ventral prostate Mast cells Stereology |
topic |
Carbamazepine Ventral prostate Mast cells Stereology |
description |
Background: Carbamazepine (CBZ) is a first-line antiepileptic drug (AED), although it is also used for the treatments of psychiatric disorders and neuropathic pain. the CBZ utilization has been associated with male reproductive damage, including hormonal alterations, sexual dysfunction and reduction of sperm quality. the wide and long-term use of the CBZ is a common schedule in children and adolescents and alters the testosterone level in adult rats and humans. the objective of this work was to evaluate the CBZ side effects on the ventral prostate of rats from pre-puberty to sexual maturation, since the prostate is an androgen-dependent organ.Methods: Twenty three day-old male albino Wistar rats received CBZ diluted in propylene glycol (20 mg/Kg/i.p via). the treatment lasted 20, 40 and 70 days, according to the different stages of the rat sexual maturation. At the end of each treatment period, ventral prostates were removed and histologically processed. the prostate sections were submitted to the histopathological, morphological and stereological analyses using image analysis system.Results: Reductions of the glandular epithelium, glandular lumen and fibromuscular stroma volume of the ventral prostate were observed in adult rats treated with CBZ since the weaning. Triggering and degranulation of mast cells were observed in the fibromuscular stroma of prepubertal and pubertal CBZ treated rats.Conclusions: the results suggest a direct effect of the CBZ on rat ventral prostate, evidenced by increase of mast cell and macrophage populations during pre-puberty and puberty causing a ventral prostate accentuated damage in the adult phase. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-03-25 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:26:59Z |
dc.date.available.fl_str_mv |
2016-01-24T14:26:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Reproductive Biology and Endocrinology. London: Biomed Central Ltd, v. 10, 15 p., 2012. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/34719 https://dx.doi.org/10.1186/1477-7827-10-22 |
dc.identifier.issn.none.fl_str_mv |
1477-7827 |
dc.identifier.file.none.fl_str_mv |
WOS000303869100001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1186/1477-7827-10-22 |
dc.identifier.wos.none.fl_str_mv |
WOS:000303869100001 |
identifier_str_mv |
Reproductive Biology and Endocrinology. London: Biomed Central Ltd, v. 10, 15 p., 2012. 1477-7827 WOS000303869100001.pdf 10.1186/1477-7827-10-22 WOS:000303869100001 |
url |
https://repositorio.unifesp.br/handle/11600/34719 https://dx.doi.org/10.1186/1477-7827-10-22 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Reproductive Biology and Endocrinology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
15 |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd |
publisher.none.fl_str_mv |
Biomed Central Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1802764195910909952 |