Biological behavior of the gerbil ventral prostate in three phases of postnatal development
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/ar.a.20347 http://hdl.handle.net/11449/21365 |
Resumo: | In this study, we characterized the gerbil's ventral prostate histology ultrastructurally and quantitatively throughout three phases of postnatal development (young, adult, and old) in order to comprehend its biological behavior and propensity to developing spontaneous lesions with aging. The gerbil prostate is composed of alveoli and ducts immersed in a stroma composed of smooth muscle, fibroblasts, collagen and elastic fibers and vessels. The prostate tissue components present morphological and quantitative aspects that vary according to age. Young animals have an immature gland with modest secretory activity. Synthetic activity remained stable in adult and old gerbil. However, prostatic morphology was altered in the aging, showing an increased epithelium and stromal fibrosis. The nuclei of the secretory cells increased with aging, whereas nucleoli presented few alterations during postnatal development. The epithelial proliferation and stromal remodeling noted in this study indicate that the gerbil prostate may respond to the androgen declines typical of senescence through epithelial proliferation and stromal remodeling. |
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Repositório Institucional da UNESP |
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Biological behavior of the gerbil ventral prostate in three phases of postnatal developmentgerbilventral prostateepitheliumstromaproliferative lesionsagingIn this study, we characterized the gerbil's ventral prostate histology ultrastructurally and quantitatively throughout three phases of postnatal development (young, adult, and old) in order to comprehend its biological behavior and propensity to developing spontaneous lesions with aging. The gerbil prostate is composed of alveoli and ducts immersed in a stroma composed of smooth muscle, fibroblasts, collagen and elastic fibers and vessels. The prostate tissue components present morphological and quantitative aspects that vary according to age. Young animals have an immature gland with modest secretory activity. Synthetic activity remained stable in adult and old gerbil. However, prostatic morphology was altered in the aging, showing an increased epithelium and stromal fibrosis. The nuclei of the secretory cells increased with aging, whereas nucleoli presented few alterations during postnatal development. The epithelial proliferation and stromal remodeling noted in this study indicate that the gerbil prostate may respond to the androgen declines typical of senescence through epithelial proliferation and stromal remodeling.UNESP, IBILCE, Dept Biol, Lab Microscopy & Microanalysis, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUniv Estadual Campinas, Inst Biol, Dept Cell Biol, São Paulo, BrazilUNESP, IBILCE, Dept Biol, Lab Microscopy & Microanalysis, BR-15054000 Sao Jose do Rio Preto, SP, BrazilWiley-BlackwellUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)De Campos, SGPZanetoni, C.Goes, R. M.Taboga, SR2014-05-20T14:00:24Z2014-05-20T14:00:24Z2006-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article723-733application/pdfhttp://dx.doi.org/10.1002/ar.a.20347Anatomical Record Part A-discoveries In Molecular Cellular and Evolutionary Biology. Hoboken: Wiley-liss, v. 288A, n. 7, p. 723-733, 2006.1552-4884http://hdl.handle.net/11449/2136510.1002/ar.a.20347WOS:000238731700008WOS000238731700008.pdf09471933473121570000-0002-0970-42880000-0002-3622-460XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnatomical Record Part A-discoveries In Molecular Cellular and Evolutionary Biologyinfo:eu-repo/semantics/openAccess2024-04-11T19:33:51Zoai:repositorio.unesp.br:11449/21365Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:20:43.444104Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development |
title |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development |
spellingShingle |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development De Campos, SGP gerbil ventral prostate epithelium stroma proliferative lesions aging |
title_short |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development |
title_full |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development |
title_fullStr |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development |
title_full_unstemmed |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development |
title_sort |
Biological behavior of the gerbil ventral prostate in three phases of postnatal development |
author |
De Campos, SGP |
author_facet |
De Campos, SGP Zanetoni, C. Goes, R. M. Taboga, SR |
author_role |
author |
author2 |
Zanetoni, C. Goes, R. M. Taboga, SR |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) |
dc.contributor.author.fl_str_mv |
De Campos, SGP Zanetoni, C. Goes, R. M. Taboga, SR |
dc.subject.por.fl_str_mv |
gerbil ventral prostate epithelium stroma proliferative lesions aging |
topic |
gerbil ventral prostate epithelium stroma proliferative lesions aging |
description |
In this study, we characterized the gerbil's ventral prostate histology ultrastructurally and quantitatively throughout three phases of postnatal development (young, adult, and old) in order to comprehend its biological behavior and propensity to developing spontaneous lesions with aging. The gerbil prostate is composed of alveoli and ducts immersed in a stroma composed of smooth muscle, fibroblasts, collagen and elastic fibers and vessels. The prostate tissue components present morphological and quantitative aspects that vary according to age. Young animals have an immature gland with modest secretory activity. Synthetic activity remained stable in adult and old gerbil. However, prostatic morphology was altered in the aging, showing an increased epithelium and stromal fibrosis. The nuclei of the secretory cells increased with aging, whereas nucleoli presented few alterations during postnatal development. The epithelial proliferation and stromal remodeling noted in this study indicate that the gerbil prostate may respond to the androgen declines typical of senescence through epithelial proliferation and stromal remodeling. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-07-01 2014-05-20T14:00:24Z 2014-05-20T14:00:24Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/ar.a.20347 Anatomical Record Part A-discoveries In Molecular Cellular and Evolutionary Biology. Hoboken: Wiley-liss, v. 288A, n. 7, p. 723-733, 2006. 1552-4884 http://hdl.handle.net/11449/21365 10.1002/ar.a.20347 WOS:000238731700008 WOS000238731700008.pdf 0947193347312157 0000-0002-0970-4288 0000-0002-3622-460X |
url |
http://dx.doi.org/10.1002/ar.a.20347 http://hdl.handle.net/11449/21365 |
identifier_str_mv |
Anatomical Record Part A-discoveries In Molecular Cellular and Evolutionary Biology. Hoboken: Wiley-liss, v. 288A, n. 7, p. 723-733, 2006. 1552-4884 10.1002/ar.a.20347 WOS:000238731700008 WOS000238731700008.pdf 0947193347312157 0000-0002-0970-4288 0000-0002-3622-460X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anatomical Record Part A-discoveries In Molecular Cellular and Evolutionary Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
723-733 application/pdf |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128922742685696 |