Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1155/2016/9151607 http://repositorio.unifesp.br/handle/11600/49330 |
Resumo: | Objective. To evaluate the expression of inflammatory markers in experimental renal failure after fetal programming. Methods. The offspring aged two and fivemonths were divided into four groups: CC (control dams, control offspring) |
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Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failureEndothelial Growth-FactorDiabetic-NephropathyHolocaust SurvivorsInsulin-ResistanceE-SelectinTnf-AlphaDiseaseGenotoxicityPathogenesisPregnancyObjective. To evaluate the expression of inflammatory markers in experimental renal failure after fetal programming. Methods. The offspring aged two and fivemonths were divided into four groups: CC (control dams, control offspring)DC (diabetic dams, control offspring)CFA (control dams, folic acid offspring, 250 mg/Kg)and DFA (diabetic dams, folic acid offspring). Gene expression of inflammatory markersMCP-1, IL-1, NOS3, TGF-beta, TNF-alpha, and VEGF was evaluated by RT-PCR. Results. MCP-1 was increased in the CFA and DFA groups at two and fivemonths of age, as well as in DC5 when compared to CC5. There was a higher expression of IL-1 in the CFA2, DFA2, and DC2 groups. There was a decrease in NOS3 and an increase in TNF-alpha in DFA5 in relation to CFA5. The gene expression of TGF-beta increased in cases that had received folic acid at two and five months, and VEGF decreased in the CFA5 and DFA5 groups. DC5 showed increased VEGF expression in comparison with CC5. Conclusions. Gestational diabetes mellitus and folic acid both change the expression of inflammatory markers, thus demonstrating that the exposure to harmful agents in adulthood has a more severe impact in cases which underwent fetal reprogramming.Discipline of General Pathology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, BrazilDepartment of Health Sciences, Lavras Federal University, Lavras, MG, BrazilDiscipline of Physiology, Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, MG, BrazilNephrology Division, Federal University of São Paulo (UNIFESP), São Paulo, SP, BrazilDepartment of Immunology, Institute of Biomedical Sciences IV, University of São Paulo (USP), São Paulo, SP, BrazilDepartment of General Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, BrazilNephrology Division, Federal University of São Paulo (UNIFESP), São Paulo, SP, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundacao de Ensino e Pesquisa de Uberaba (FUNEPU)Czech Acad Sci, Inst Entomology2019-01-21T10:29:41Z2019-01-21T10:29:41Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://dx.doi.org/10.1155/2016/9151607Journal Of Immunology Research. New york, 2016.10.1155/2016/9151607WOS000390014700001.pdf2314-8861http://repositorio.unifesp.br/handle/11600/49330WOS:000390014700001engJournal Of Immunology Researchinfo:eu-repo/semantics/openAccessPereira Junior, Carlos Donizetede Oliveira Guimaraes, Camila SouzaSouza da Silva, Aline CristinaAquiles Rodrigues, Aldo Rogelisda Gloria, Maria Aparecida [UNIFESP]Antunes Teixeira, Vicente de PaulaSaraiva Camara, Niels Olsen [UNIFESP]Rocha, Lenaldo Brancodos Reis, Marlene AntoniaMachado, Juliana ReisRocha, Laura PennaHelmo, Fernanda RodriguesMiranda Correa, Rosana Rosareponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-02T06:50:11Zoai:repositorio.unifesp.br/:11600/49330Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-02T06:50:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure |
| title |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure |
| spellingShingle |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure Pereira Junior, Carlos Donizete Endothelial Growth-Factor Diabetic-Nephropathy Holocaust Survivors Insulin-Resistance E-Selectin Tnf-Alpha Disease Genotoxicity Pathogenesis Pregnancy |
| title_short |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure |
| title_full |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure |
| title_fullStr |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure |
| title_full_unstemmed |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure |
| title_sort |
Influence of the expression of inflammatory markers on kidney after fetal programming in an experimental model of renal failure |
| author |
Pereira Junior, Carlos Donizete |
| author_facet |
Pereira Junior, Carlos Donizete de Oliveira Guimaraes, Camila Souza Souza da Silva, Aline Cristina Aquiles Rodrigues, Aldo Rogelis da Gloria, Maria Aparecida [UNIFESP] Antunes Teixeira, Vicente de Paula Saraiva Camara, Niels Olsen [UNIFESP] Rocha, Lenaldo Branco dos Reis, Marlene Antonia Machado, Juliana Reis Rocha, Laura Penna Helmo, Fernanda Rodrigues Miranda Correa, Rosana Rosa |
| author_role |
author |
| author2 |
de Oliveira Guimaraes, Camila Souza Souza da Silva, Aline Cristina Aquiles Rodrigues, Aldo Rogelis da Gloria, Maria Aparecida [UNIFESP] Antunes Teixeira, Vicente de Paula Saraiva Camara, Niels Olsen [UNIFESP] Rocha, Lenaldo Branco dos Reis, Marlene Antonia Machado, Juliana Reis Rocha, Laura Penna Helmo, Fernanda Rodrigues Miranda Correa, Rosana Rosa |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira Junior, Carlos Donizete de Oliveira Guimaraes, Camila Souza Souza da Silva, Aline Cristina Aquiles Rodrigues, Aldo Rogelis da Gloria, Maria Aparecida [UNIFESP] Antunes Teixeira, Vicente de Paula Saraiva Camara, Niels Olsen [UNIFESP] Rocha, Lenaldo Branco dos Reis, Marlene Antonia Machado, Juliana Reis Rocha, Laura Penna Helmo, Fernanda Rodrigues Miranda Correa, Rosana Rosa |
| dc.subject.por.fl_str_mv |
Endothelial Growth-Factor Diabetic-Nephropathy Holocaust Survivors Insulin-Resistance E-Selectin Tnf-Alpha Disease Genotoxicity Pathogenesis Pregnancy |
| topic |
Endothelial Growth-Factor Diabetic-Nephropathy Holocaust Survivors Insulin-Resistance E-Selectin Tnf-Alpha Disease Genotoxicity Pathogenesis Pregnancy |
| description |
Objective. To evaluate the expression of inflammatory markers in experimental renal failure after fetal programming. Methods. The offspring aged two and fivemonths were divided into four groups: CC (control dams, control offspring) |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2019-01-21T10:29:41Z 2019-01-21T10:29:41Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2016/9151607 Journal Of Immunology Research. New york, 2016. 10.1155/2016/9151607 WOS000390014700001.pdf 2314-8861 http://repositorio.unifesp.br/handle/11600/49330 WOS:000390014700001 |
| url |
http://dx.doi.org/10.1155/2016/9151607 http://repositorio.unifesp.br/handle/11600/49330 |
| identifier_str_mv |
Journal Of Immunology Research. New york, 2016. 10.1155/2016/9151607 WOS000390014700001.pdf 2314-8861 WOS:000390014700001 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal Of Immunology Research |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Czech Acad Sci, Inst Entomology |
| publisher.none.fl_str_mv |
Czech Acad Sci, Inst Entomology |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1814268357343444992 |