Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin

Detalhes bibliográficos
Autor(a) principal: Nussbaum, Claudia
Data de Publicação: 2015
Outros Autores: Bannenberg, Sarah, Keul, Petra, Gräler, Markus H., Albuquerque, Cassiano F. Gonçalves de, Korhonen, Hanna, Lipinski, Karin von Wnuck, Heusch, Gerd, Faria Neto, Hugo C. de Castro, Rohwedder, Ina, Göther, Joachim R., Prasad, Vysakh Pushpa, Haufe, Günter, Lange-Sperandio, Baerbel, Offermanns, Stefan, Sperandio, Markus, Levkau, Bodo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11487
Resumo: Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany.
id CRUZ_37b3baa30003adaab747a217a46ca601
oai_identifier_str oai:www.arca.fiocruz.br:icict/11487
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Nussbaum, ClaudiaBannenberg, SarahKeul, PetraGräler, Markus H.Albuquerque, Cassiano F. Gonçalves deKorhonen, HannaLipinski, Karin von WnuckHeusch, GerdFaria Neto, Hugo C. de CastroRohwedder, InaGöther, Joachim R.Prasad, Vysakh PushpaHaufe, GünterLange-Sperandio, BaerbelOffermanns, StefanSperandio, MarkusLevkau, Bodo2015-08-19T13:49:20Z2015-08-19T13:49:20Z2015NUSSBAUM, Claudia; et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications, 6:6416, 12p, 2015.2041-1723https://www.arca.fiocruz.br/handle/icict/1148710.1038/ncomms7416engMacmillan Publishers LimitedSphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLudwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.University Hospital Jena. Center for Molecular Biomedicine.Center for Sepsis Control and Care. Department of Anesthesiology and Intensive Care Medicine. Jena, Germany.Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunofarmacologia. Rio de Janeiro, RJ, Brasil.Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany.University of Duisburg-Essen.University Hospital Essen. Department of Hematology. Essen, Germany.Westfälische Wilhelms-Universität Münster. Organisch-Chemisches Institut. Münster, Germany.Westfälische Wilhelms-Universität Münster. Organisch-Chemisches Institut. Münster, Germany.Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany.Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany.University of Duisburg-Essen. University Hospital Essen. West German Heart and Vascular Center. Institute of Pathophysiology. Essen, Germany.Sphingosine-1-phosphate (S1P) participates in inflammation; however, its role in leukocyte rolling is still unclear. Here we use intravital microscopy in inflamed mouse cremaster muscle venules and human endothelial cells to show that S1P contributes to P-selectin-dependent leukocyte rolling through endothelial S1P receptor 3 (S1P3) and Gαq, PLCβ and Ca(2+). Intra-arterial S1P administration increases leukocyte rolling, while S1P3 deficiency or inhibition dramatically reduces it. Mast cells involved in triggering rolling also release S1P that mobilizes P-selectin through S1P3. Histamine and epinephrine require S1P3 for full-scale effect accomplishing it by stimulating sphingosine kinase 1 (Sphk1). In a counter-regulatory manner, S1P1 inhibits cAMP-stimulated Sphk1 and blocks rolling as observed in endothelial-specific S1P1(-/-) mice. In agreement with a dominant pro-rolling effect of S1P3, FTY720 inhibits rolling in control and S1P1(-/-) but not in S1P3(-/-) mice. Our findings identify S1P as a direct and indirect contributor to leukocyte rolling and characterize the receptors mediating its action.Endothelial P-selectinSphingosine-1-phosphateLeukocyteSelectina-PPsicosinaLeucócitosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11487/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALhugo_farianeto_etal_IOC_2015.pdfapplication/pdf1192166https://www.arca.fiocruz.br/bitstream/icict/11487/2/hugo_farianeto_etal_IOC_2015.pdfeb61819d2e63cfa1e06be0a5935a3cd3MD52TEXThugo_farianeto_etal_IOC_2015.pdf.txthugo_farianeto_etal_IOC_2015.pdf.txtExtracted texttext/plain76718https://www.arca.fiocruz.br/bitstream/icict/11487/3/hugo_farianeto_etal_IOC_2015.pdf.txt92596527116aa43277f850e7358798adMD53icict/114872022-06-24 13:08:52.918oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:52Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
title Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
spellingShingle Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
Nussbaum, Claudia
Endothelial P-selectin
Sphingosine-1-phosphate
Leukocyte
Selectina-P
Psicosina
Leucócitos
title_short Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
title_full Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
title_fullStr Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
title_full_unstemmed Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
title_sort Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
author Nussbaum, Claudia
author_facet Nussbaum, Claudia
Bannenberg, Sarah
Keul, Petra
Gräler, Markus H.
Albuquerque, Cassiano F. Gonçalves de
Korhonen, Hanna
Lipinski, Karin von Wnuck
Heusch, Gerd
Faria Neto, Hugo C. de Castro
Rohwedder, Ina
Göther, Joachim R.
Prasad, Vysakh Pushpa
Haufe, Günter
Lange-Sperandio, Baerbel
Offermanns, Stefan
Sperandio, Markus
Levkau, Bodo
author_role author
author2 Bannenberg, Sarah
Keul, Petra
Gräler, Markus H.
Albuquerque, Cassiano F. Gonçalves de
Korhonen, Hanna
Lipinski, Karin von Wnuck
Heusch, Gerd
Faria Neto, Hugo C. de Castro
Rohwedder, Ina
Göther, Joachim R.
Prasad, Vysakh Pushpa
Haufe, Günter
Lange-Sperandio, Baerbel
Offermanns, Stefan
Sperandio, Markus
Levkau, Bodo
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nussbaum, Claudia
Bannenberg, Sarah
Keul, Petra
Gräler, Markus H.
Albuquerque, Cassiano F. Gonçalves de
Korhonen, Hanna
Lipinski, Karin von Wnuck
Heusch, Gerd
Faria Neto, Hugo C. de Castro
Rohwedder, Ina
Göther, Joachim R.
Prasad, Vysakh Pushpa
Haufe, Günter
Lange-Sperandio, Baerbel
Offermanns, Stefan
Sperandio, Markus
Levkau, Bodo
dc.subject.en.pt_BR.fl_str_mv Endothelial P-selectin
Sphingosine-1-phosphate
Leukocyte
topic Endothelial P-selectin
Sphingosine-1-phosphate
Leukocyte
Selectina-P
Psicosina
Leucócitos
dc.subject.decs.pt_BR.fl_str_mv Selectina-P
Psicosina
Leucócitos
description Ludwig Maximilians Universität München. Walter Brendel Center, Münche, Germany / Ludwig Maximilians University München. Dr v. Haunersches Children’s Hospital. München, Germany.
publishDate 2015
dc.date.accessioned.fl_str_mv 2015-08-19T13:49:20Z
dc.date.available.fl_str_mv 2015-08-19T13:49:20Z
dc.date.issued.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NUSSBAUM, Claudia; et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications, 6:6416, 12p, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11487
dc.identifier.issn.pt_BR.fl_str_mv 2041-1723
dc.identifier.doi.pt_BR.fl_str_mv 10.1038/ncomms7416
identifier_str_mv NUSSBAUM, Claudia; et al. Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. Nature Communications, 6:6416, 12p, 2015.
2041-1723
10.1038/ncomms7416
url https://www.arca.fiocruz.br/handle/icict/11487
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Macmillan Publishers Limited
publisher.none.fl_str_mv Macmillan Publishers Limited
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/11487/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/11487/2/hugo_farianeto_etal_IOC_2015.pdf
https://www.arca.fiocruz.br/bitstream/icict/11487/3/hugo_farianeto_etal_IOC_2015.pdf.txt
bitstream.checksum.fl_str_mv 7d48279ffeed55da8dfe2f8e81f3b81f
eb61819d2e63cfa1e06be0a5935a3cd3
92596527116aa43277f850e7358798ad
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1798324817951195136

Registros relacionados