Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country

Detalhes bibliográficos
Autor(a) principal: Velloso, Elvira Deolinda Rodrigues Pereira
Data de Publicação: 2013
Outros Autores: Chauffaille, Maria de Lourdes [UNIFESP], Pelicario, L. M., Tanizawa, Roberta Sandra da Silva, Toledo, Silvia Regina Caminada de [UNIFESP], Gaiolla, R. D., Lopes, L. F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/1414-431X20122449
http://repositorio.unifesp.br/handle/11600/35720
Resumo: Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.
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spelling Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging countryChildhood myelodysplastic syndromesJuvenile myelomonocytic leukemiaCytogeneticsKaryotypeDiagnosisMyelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.Univ São Paulo, Fac Med, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniv São Paulo, Fac Med, Dept Hematol, Lab Citogenet, São Paulo, BrazilUniversidade Federal de São Paulo, Inst Oncol Pediat, São Paulo, BrazilUniv Estadual Paulista, Fac Med Botucatu, Dept Clin Med, Botucatu, SP, BrazilHosp Canc Barretos, Barretos, SP, BrazilCtr Tratamento Fabiana Macedo de Morais, Grp Assistencia Crianca Canc, Grp Cooperat Brasileiro Sindrome Mielodisplas Ped, Sao Jose Dos Campos, SP, BrazilUniversidade Federal de São Paulo, Dept Hematol, São Paulo, BrazilUniversidade Federal de São Paulo, Inst Oncol Pediat, São Paulo, BrazilWeb of ScienceAssoc Bras Divulg CientificaUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Hosp Canc BarretosCtr Tratamento Fabiana Macedo de MoraisVelloso, Elvira Deolinda Rodrigues PereiraChauffaille, Maria de Lourdes [UNIFESP]Pelicario, L. M.Tanizawa, Roberta Sandra da SilvaToledo, Silvia Regina Caminada de [UNIFESP]Gaiolla, R. D.Lopes, L. F.2016-01-24T14:30:55Z2016-01-24T14:30:55Z2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion85-90application/pdfhttp://dx.doi.org/10.1590/1414-431X20122449Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013.10.1590/1414-431X20122449S0100-879X2013000100085.pdf0100-879XS0100-879X2013000100085http://repositorio.unifesp.br/handle/11600/35720WOS:000316126700011engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T04:29:16Zoai:repositorio.unifesp.br/:11600/35720Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T04:29:16Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
spellingShingle Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
Velloso, Elvira Deolinda Rodrigues Pereira
Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia
Cytogenetics
Karyotype
Diagnosis
title_short Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_full Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_fullStr Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_full_unstemmed Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
title_sort Cytogenetic studies of Brazilian pediatric myelodysplastic syndrome cases: challenges and difficulties in a large and emerging country
author Velloso, Elvira Deolinda Rodrigues Pereira
author_facet Velloso, Elvira Deolinda Rodrigues Pereira
Chauffaille, Maria de Lourdes [UNIFESP]
Pelicario, L. M.
Tanizawa, Roberta Sandra da Silva
Toledo, Silvia Regina Caminada de [UNIFESP]
Gaiolla, R. D.
Lopes, L. F.
author_role author
author2 Chauffaille, Maria de Lourdes [UNIFESP]
Pelicario, L. M.
Tanizawa, Roberta Sandra da Silva
Toledo, Silvia Regina Caminada de [UNIFESP]
Gaiolla, R. D.
Lopes, L. F.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Hosp Canc Barretos
Ctr Tratamento Fabiana Macedo de Morais
dc.contributor.author.fl_str_mv Velloso, Elvira Deolinda Rodrigues Pereira
Chauffaille, Maria de Lourdes [UNIFESP]
Pelicario, L. M.
Tanizawa, Roberta Sandra da Silva
Toledo, Silvia Regina Caminada de [UNIFESP]
Gaiolla, R. D.
Lopes, L. F.
dc.subject.por.fl_str_mv Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia
Cytogenetics
Karyotype
Diagnosis
topic Childhood myelodysplastic syndromes
Juvenile myelomonocytic leukemia
Cytogenetics
Karyotype
Diagnosis
description Myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) are rare hematopoietic stem cell diseases affecting children. Cytogenetics plays an important role in the diagnosis of these diseases. We report here the experience of the Cytogenetic Subcommittee of the Brazilian Cooperative Group on Pediatric Myelodysplastic Syndromes (BCG-MDS-PED). We analyzed 168 cytogenetic studies performed in 23 different cytogenetic centers; 84 of these studies were performed in patients with confirmed MDS (primary MDS, secondary MDS, JMML, and acute myeloid leukemia/MDS+Down syndrome). Clonal abnormalities were found in 36.9% of the MDS cases and cytogenetic studies were important for the detection of constitutional diseases and for differential diagnosis with other myeloid neoplasms. These data show the importance of the Cooperative Group for continuing education in order to avoid a late or wrong diagnosis.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2016-01-24T14:30:55Z
2016-01-24T14:30:55Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/1414-431X20122449
Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013.
10.1590/1414-431X20122449
S0100-879X2013000100085.pdf
0100-879X
S0100-879X2013000100085
http://repositorio.unifesp.br/handle/11600/35720
WOS:000316126700011
url http://dx.doi.org/10.1590/1414-431X20122449
http://repositorio.unifesp.br/handle/11600/35720
identifier_str_mv Brazilian Journal of Medical and Biological Research. São Paulo: Assoc Bras Divulg Cientifica, v. 46, n. 1, p. 85-90, 2013.
10.1590/1414-431X20122449
S0100-879X2013000100085.pdf
0100-879X
S0100-879X2013000100085
WOS:000316126700011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 85-90
application/pdf
dc.publisher.none.fl_str_mv Assoc Bras Divulg Cientifica
publisher.none.fl_str_mv Assoc Bras Divulg Cientifica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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