Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
Autor(a) principal: | |
---|---|
Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0074-02762012000100020 http://repositorio.unifesp.br/handle/11600/6958 |
Resumo: | The innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli (EIEC) infection were compared with DC responses to Shigella flexneri infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases. |
id |
UFSP_85452481aa96c9e1f4ab508bb4098f66 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/6958 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation statesenteroinvasive Escherichia coliShigella flexneridendritic cellsinnate immune responseThe innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli (EIEC) infection were compared with DC responses to Shigella flexneri infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases.Universidade de São Paulo Faculdade de Ciências FarmacêuticasUniversidade Federal de São Paulo (UNIFESP) Departamento de Doenças InfecciosasUNIFESP, Depto. de Doenças InfecciosasSciELOInstituto Oswaldo Cruz, Ministério da SaúdeUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Moreno, Ana Carolina RamosFerreira, Karen Spadari [UNIFESP]Ferreira, Lucas GonçalvesAlmeida, Sandro Rogério de [UNIFESP]Martinez, Marina Baquerizo2015-06-14T13:43:36Z2015-06-14T13:43:36Z2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion138-141application/pdfhttp://dx.doi.org/10.1590/S0074-02762012000100020Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 1, p. 138-141, 2012.10.1590/S0074-02762012000100020S0074-02762012000100020.pdf0074-0276S0074-02762012000100020http://repositorio.unifesp.br/handle/11600/6958WOS:000300062500020engMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T23:52:39Zoai:repositorio.unifesp.br/:11600/6958Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T23:52:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states |
title |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states |
spellingShingle |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states Moreno, Ana Carolina Ramos enteroinvasive Escherichia coli Shigella flexneri dendritic cells innate immune response |
title_short |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states |
title_full |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states |
title_fullStr |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states |
title_full_unstemmed |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states |
title_sort |
Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states |
author |
Moreno, Ana Carolina Ramos |
author_facet |
Moreno, Ana Carolina Ramos Ferreira, Karen Spadari [UNIFESP] Ferreira, Lucas Gonçalves Almeida, Sandro Rogério de [UNIFESP] Martinez, Marina Baquerizo |
author_role |
author |
author2 |
Ferreira, Karen Spadari [UNIFESP] Ferreira, Lucas Gonçalves Almeida, Sandro Rogério de [UNIFESP] Martinez, Marina Baquerizo |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Moreno, Ana Carolina Ramos Ferreira, Karen Spadari [UNIFESP] Ferreira, Lucas Gonçalves Almeida, Sandro Rogério de [UNIFESP] Martinez, Marina Baquerizo |
dc.subject.por.fl_str_mv |
enteroinvasive Escherichia coli Shigella flexneri dendritic cells innate immune response |
topic |
enteroinvasive Escherichia coli Shigella flexneri dendritic cells innate immune response |
description |
The innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli (EIEC) infection were compared with DC responses to Shigella flexneri infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-02-01 2015-06-14T13:43:36Z 2015-06-14T13:43:36Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0074-02762012000100020 Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 1, p. 138-141, 2012. 10.1590/S0074-02762012000100020 S0074-02762012000100020.pdf 0074-0276 S0074-02762012000100020 http://repositorio.unifesp.br/handle/11600/6958 WOS:000300062500020 |
url |
http://dx.doi.org/10.1590/S0074-02762012000100020 http://repositorio.unifesp.br/handle/11600/6958 |
identifier_str_mv |
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 1, p. 138-141, 2012. 10.1590/S0074-02762012000100020 S0074-02762012000100020.pdf 0074-0276 S0074-02762012000100020 WOS:000300062500020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
138-141 application/pdf |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268351320424448 |