Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states

Detalhes bibliográficos
Autor(a) principal: Moreno, Ana Carolina Ramos
Data de Publicação: 2012
Outros Autores: Ferreira, Karen Spadari [UNIFESP], Ferreira, Lucas Gonçalves, Almeida, Sandro Rogério de [UNIFESP], Martinez, Marina Baquerizo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0074-02762012000100020
http://repositorio.unifesp.br/handle/11600/6958
Resumo: The innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli (EIEC) infection were compared with DC responses to Shigella flexneri infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases.
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spelling Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation statesenteroinvasive Escherichia coliShigella flexneridendritic cellsinnate immune responseThe innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli (EIEC) infection were compared with DC responses to Shigella flexneri infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases.Universidade de São Paulo Faculdade de Ciências FarmacêuticasUniversidade Federal de São Paulo (UNIFESP) Departamento de Doenças InfecciosasUNIFESP, Depto. de Doenças InfecciosasSciELOInstituto Oswaldo Cruz, Ministério da SaúdeUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Moreno, Ana Carolina RamosFerreira, Karen Spadari [UNIFESP]Ferreira, Lucas GonçalvesAlmeida, Sandro Rogério de [UNIFESP]Martinez, Marina Baquerizo2015-06-14T13:43:36Z2015-06-14T13:43:36Z2012-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion138-141application/pdfhttp://dx.doi.org/10.1590/S0074-02762012000100020Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 1, p. 138-141, 2012.10.1590/S0074-02762012000100020S0074-02762012000100020.pdf0074-0276S0074-02762012000100020http://repositorio.unifesp.br/handle/11600/6958WOS:000300062500020engMemórias do Instituto Oswaldo Cruzinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T23:52:39Zoai:repositorio.unifesp.br/:11600/6958Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T23:52:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
title Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
spellingShingle Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
Moreno, Ana Carolina Ramos
enteroinvasive Escherichia coli
Shigella flexneri
dendritic cells
innate immune response
title_short Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
title_full Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
title_fullStr Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
title_full_unstemmed Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
title_sort Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states
author Moreno, Ana Carolina Ramos
author_facet Moreno, Ana Carolina Ramos
Ferreira, Karen Spadari [UNIFESP]
Ferreira, Lucas Gonçalves
Almeida, Sandro Rogério de [UNIFESP]
Martinez, Marina Baquerizo
author_role author
author2 Ferreira, Karen Spadari [UNIFESP]
Ferreira, Lucas Gonçalves
Almeida, Sandro Rogério de [UNIFESP]
Martinez, Marina Baquerizo
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Moreno, Ana Carolina Ramos
Ferreira, Karen Spadari [UNIFESP]
Ferreira, Lucas Gonçalves
Almeida, Sandro Rogério de [UNIFESP]
Martinez, Marina Baquerizo
dc.subject.por.fl_str_mv enteroinvasive Escherichia coli
Shigella flexneri
dendritic cells
innate immune response
topic enteroinvasive Escherichia coli
Shigella flexneri
dendritic cells
innate immune response
description The innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli (EIEC) infection were compared with DC responses to Shigella flexneri infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
2015-06-14T13:43:36Z
2015-06-14T13:43:36Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0074-02762012000100020
Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 1, p. 138-141, 2012.
10.1590/S0074-02762012000100020
S0074-02762012000100020.pdf
0074-0276
S0074-02762012000100020
http://repositorio.unifesp.br/handle/11600/6958
WOS:000300062500020
url http://dx.doi.org/10.1590/S0074-02762012000100020
http://repositorio.unifesp.br/handle/11600/6958
identifier_str_mv Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 1, p. 138-141, 2012.
10.1590/S0074-02762012000100020
S0074-02762012000100020.pdf
0074-0276
S0074-02762012000100020
WOS:000300062500020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Memórias do Instituto Oswaldo Cruz
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 138-141
application/pdf
dc.publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
publisher.none.fl_str_mv Instituto Oswaldo Cruz, Ministério da Saúde
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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