Coenzyme Q(10) exogenous administration attenuates cold stress cardiac injury

• Autor(a) principal: Murad, Neif [UNIFESP]
• Data de Publicação: 2001
• Outros Autores: Takiuchi, Katia [UNIFESP], Lopes, Antonio C. [UNIFESP], Bonilha, André MM [UNIFESP], Souza, Marcio M. [UNIFESP], Demarchi, Lea Maria MF, Higuchi, Maria de Lourdes, Tucci, Paulo JF [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/001300000dk3w
• DOI: 10.1536/jhj.42.327
• Texto Completo: http://dx.doi.org/10.1536/jhj.42.327; http://repositorio.unifesp.br/handle/11600/26537
• topic: ubiquinone; coenzyme Q(10); cold stress test; systolic function; diastolic; function

The influence of coenzyme Q(10) (CoQ(10)) in cold stress test (-15 degreesC for 4 hours) cardiac functional impairment was studied in isolated isovolumic heart of control rats (C; n=12) and of placebo (P; n=11) and treated rats (CoQ(10); n=10). in addition, electron microscopic evaluation of left ventricular (LV) slices (n=3 in each group) allowed us to analyze the myocardial ultrastructure. Maximal values of developed pressure (DPmax) were similarly decreased in cold stressed animals (C=129 +/-3.9 mmHg; P=106 +/-6.7 mmHg; CoQ(10)=91 +/-3.9 mmHg); however, volume-induced enhancement of pressure generation (slope of DP / volume relations: C=0.248 +/-0.0203 mmHg/mul; P=0.2831 +/-0.0187 mmHg/mul; CoQ(10)=0.2387 (0.0225 mmHg/mul; p >0.05), and the duration of systole (C=80 +/- .6 ms; P=78 +/-1.3 ms; CoQ(10) = 80 +/-2.7 ms) were not altered. Myocardial relaxation, evaluated by the relaxation constant (C=39 +/-1.9 ins; P=42 +/-3.4 ms; CoQ(10)=51 +/-6.0 ms), as well as resting stress / strain relations were unaffected by cold stress. Myocardial samples showed that pretreatment with CoQ(10) attenuates myofibrillar and mitochondrial lesions, and prevents mitochondrial fractional area increase (P: 53.11%> CoQ(10): 38.78%=C: 33.87%; p <0.005) indicating that the exogenous administration of CoQ(10) can reduce cold stress myocardial injury.