Expression of behavioral sensitization to ethanol is increased by energy drink administration
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36662 http://dx.doi.org/10.1016/j.pbb.2013.07.014 |
Resumo: | Alcohol abuse and dependence are important medical, social and economical problems, affecting millions of people. A relatively recent habit among young people is mixing alcohol with energy drinks (ED), in spite of the risks involved may be higher than those associated with alcohol consumption alone. the mixture of alcohol and energy drinks, both with stimulant properties, may alter the perception of intoxication and could lead individuals to believe they are less drunk and can drink more or for longer periods of time. in animals, the repeated administration of ethanol can lead to a progressive increase of the locomotor stimulant effect, known as behavioral sensitization, a drug-dependent behavioral plasticity associated with vulnerability to addiction. As well as for addiction, there are clear individual differences in the level of sensitization to ethanol among species and even among individuals from the same strain. the present study assessed how ED affects the expression of ethanol sensitization. Female mice chronically treated with ethanol (2.4 g/kg) were classified as low-sensitized or high-sensitized. Two days later, different groups of mice were submitted to saline + water, ethanol + water or ethanol + ED systemic challenges. As expected, only the high-sensitized group expressed clear sensitization after ethanol administration. However, the administration of ethanol + ED triggered the sensitization expression in the low-sensitized group. These data indicate that the combined use of ED and ethanol can potentiate the stimulant and, consequently, the reward effects of ethanol in previously treated mice. If a similar process occurs in human beings, the use of ED can increase the risk of developing alcohol abuse or dependence. (C) 2013 Elsevier Inc. All rights reserved. |
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Ferreira, Sionaldo Eduardo [UNIFESP]Abrahao, Karina Possa [UNIFESP]Souza-Formigoni, Maria Lucia Oliveira de [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:34:18Z2016-01-24T14:34:18Z2013-09-01Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 110, p. 245-248, 2013.0091-3057http://repositorio.unifesp.br/handle/11600/36662http://dx.doi.org/10.1016/j.pbb.2013.07.014WOS000327112200032.pdf10.1016/j.pbb.2013.07.014WOS:000327112200032Alcohol abuse and dependence are important medical, social and economical problems, affecting millions of people. A relatively recent habit among young people is mixing alcohol with energy drinks (ED), in spite of the risks involved may be higher than those associated with alcohol consumption alone. the mixture of alcohol and energy drinks, both with stimulant properties, may alter the perception of intoxication and could lead individuals to believe they are less drunk and can drink more or for longer periods of time. in animals, the repeated administration of ethanol can lead to a progressive increase of the locomotor stimulant effect, known as behavioral sensitization, a drug-dependent behavioral plasticity associated with vulnerability to addiction. As well as for addiction, there are clear individual differences in the level of sensitization to ethanol among species and even among individuals from the same strain. the present study assessed how ED affects the expression of ethanol sensitization. Female mice chronically treated with ethanol (2.4 g/kg) were classified as low-sensitized or high-sensitized. Two days later, different groups of mice were submitted to saline + water, ethanol + water or ethanol + ED systemic challenges. As expected, only the high-sensitized group expressed clear sensitization after ethanol administration. However, the administration of ethanol + ED triggered the sensitization expression in the low-sensitized group. These data indicate that the combined use of ED and ethanol can potentiate the stimulant and, consequently, the reward effects of ethanol in previously treated mice. If a similar process occurs in human beings, the use of ED can increase the risk of developing alcohol abuse or dependence. (C) 2013 Elsevier Inc. All rights reserved.Associacao Fundo de Incentivo a Pesquisa (AFIP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Federal de São Paulo UNIFESP, Dept Ps Biol, Esco Paulista Med, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Ps Biol, Esco Paulista Med, BR-04023062 São Paulo, BrazilFAPESP: FAPESP 02/04191-0Web of Science245-248engElsevier B.V.Pharmacology Biochemistry and Behaviorhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessEthanolEnergy drinkLocomotor sensitizationIndividual variabilityExpression of behavioral sensitization to ethanol is increased by energy drink administrationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000327112200032.pdfapplication/pdf346433${dspace.ui.url}/bitstream/11600/36662/1/WOS000327112200032.pdf251cb23b7f4afc9fd236017a757293fcMD51open accessTEXTWOS000327112200032.pdf.txtWOS000327112200032.pdf.txtExtracted texttext/plain29178${dspace.ui.url}/bitstream/11600/36662/9/WOS000327112200032.pdf.txte4c3080e42d5b02aac3df96fa02bbcebMD59open accessTHUMBNAILWOS000327112200032.pdf.jpgWOS000327112200032.pdf.jpgIM Thumbnailimage/jpeg8158${dspace.ui.url}/bitstream/11600/36662/11/WOS000327112200032.pdf.jpg8e50720b38dd8c5f37f8bce9e9c6df43MD511open access11600/366622023-06-05 19:23:37.26open accessoai:repositorio.unifesp.br:11600/36662Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:23:37Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Expression of behavioral sensitization to ethanol is increased by energy drink administration |
title |
Expression of behavioral sensitization to ethanol is increased by energy drink administration |
spellingShingle |
Expression of behavioral sensitization to ethanol is increased by energy drink administration Ferreira, Sionaldo Eduardo [UNIFESP] Ethanol Energy drink Locomotor sensitization Individual variability |
title_short |
Expression of behavioral sensitization to ethanol is increased by energy drink administration |
title_full |
Expression of behavioral sensitization to ethanol is increased by energy drink administration |
title_fullStr |
Expression of behavioral sensitization to ethanol is increased by energy drink administration |
title_full_unstemmed |
Expression of behavioral sensitization to ethanol is increased by energy drink administration |
title_sort |
Expression of behavioral sensitization to ethanol is increased by energy drink administration |
author |
Ferreira, Sionaldo Eduardo [UNIFESP] |
author_facet |
Ferreira, Sionaldo Eduardo [UNIFESP] Abrahao, Karina Possa [UNIFESP] Souza-Formigoni, Maria Lucia Oliveira de [UNIFESP] |
author_role |
author |
author2 |
Abrahao, Karina Possa [UNIFESP] Souza-Formigoni, Maria Lucia Oliveira de [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Ferreira, Sionaldo Eduardo [UNIFESP] Abrahao, Karina Possa [UNIFESP] Souza-Formigoni, Maria Lucia Oliveira de [UNIFESP] |
dc.subject.eng.fl_str_mv |
Ethanol Energy drink Locomotor sensitization Individual variability |
topic |
Ethanol Energy drink Locomotor sensitization Individual variability |
description |
Alcohol abuse and dependence are important medical, social and economical problems, affecting millions of people. A relatively recent habit among young people is mixing alcohol with energy drinks (ED), in spite of the risks involved may be higher than those associated with alcohol consumption alone. the mixture of alcohol and energy drinks, both with stimulant properties, may alter the perception of intoxication and could lead individuals to believe they are less drunk and can drink more or for longer periods of time. in animals, the repeated administration of ethanol can lead to a progressive increase of the locomotor stimulant effect, known as behavioral sensitization, a drug-dependent behavioral plasticity associated with vulnerability to addiction. As well as for addiction, there are clear individual differences in the level of sensitization to ethanol among species and even among individuals from the same strain. the present study assessed how ED affects the expression of ethanol sensitization. Female mice chronically treated with ethanol (2.4 g/kg) were classified as low-sensitized or high-sensitized. Two days later, different groups of mice were submitted to saline + water, ethanol + water or ethanol + ED systemic challenges. As expected, only the high-sensitized group expressed clear sensitization after ethanol administration. However, the administration of ethanol + ED triggered the sensitization expression in the low-sensitized group. These data indicate that the combined use of ED and ethanol can potentiate the stimulant and, consequently, the reward effects of ethanol in previously treated mice. If a similar process occurs in human beings, the use of ED can increase the risk of developing alcohol abuse or dependence. (C) 2013 Elsevier Inc. All rights reserved. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-09-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:18Z |
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2016-01-24T14:34:18Z |
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Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 110, p. 245-248, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36662 http://dx.doi.org/10.1016/j.pbb.2013.07.014 |
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0091-3057 |
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WOS000327112200032.pdf |
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10.1016/j.pbb.2013.07.014 |
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WOS:000327112200032 |
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Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 110, p. 245-248, 2013. 0091-3057 WOS000327112200032.pdf 10.1016/j.pbb.2013.07.014 WOS:000327112200032 |
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