Selective hypothermia: an experimental study on traumatic brain injury in rats
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/001300000dm2v |
Texto Completo: | http://dx.doi.org/10.1590/S0004-282X2008000300021 http://repositorio.unifesp.br/handle/11600/4394 |
Resumo: | OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated. |
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Selective hypothermia: an experimental study on traumatic brain injury in ratsHipotermia seletiva: estudo experimental de traumatismo crânio-encefálico em ratosselective hypothermiahypothermianeuroprotectiontraumatic brain injuryhipotermia seletivahipotermianeuroproteçãotraumatismo crânio-encefálicoOBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.OBJETIVO: Avaliar a eficiência da hipotermia seletiva no tratamento do traumatismo crânio-encefálico (TCe) em ratos. o trauma foi produzido por um modelo de impacto cortical desenvolvido exclusivamente para o estudo. MÉTODO: Após o TCE produzido pelo modelo de impacto cortical, foi realizada pequena craniectomia na região fronto-parietal direita; após o procedimento os animais foram divididos em dois grupos de 15 cada um. o grupo A, sem tratamento com hipotermia (grupo controle) e grupo B, tratado com hipotermia seletiva por período de 5 a 6 horas. depois deste tempo todos os animais foram sacrificados, seus encéfalos foram removidos e realizada a análise anatomopatológica. RESULTADOS: Na comparação entre o grupo tratado com hipotermia e o grupo controle utilizou-se a contagem de neurônios lesados por campo. Tal contagem no grupo A (controle/sem tratamento) com n=15 teve media de 70,80 neurônios lesados por campo contra a media de 21,33 nerônios lesados por campo no grupo B (submetido ao tratamento com hipotermia), com n=15 também. diferença estatísticamente significativa pôde ser demonstrada. CONCLUSÃO: A análise anatomopatológica dos encéfalos dos animais estudados, baseada na quantificação dos neurônios lesados por campo demonstrou efetividade do tratamento com hipotermia seletiva com diferença estatística significativa.Universidade Federal de São Paulo (UNIFESP) EPMUNIFESP, EPMSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Dvilevicius, Amylcar Edemilson [UNIFESP]Prandini, Mirto Nelso [UNIFESP]2015-06-14T13:38:34Z2015-06-14T13:38:34Z2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion391-396application/pdfhttp://dx.doi.org/10.1590/S0004-282X2008000300021Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 2b, p. 391-396, 2008.10.1590/S0004-282X2008000300021S0004-282X2008000300021.pdf0004-282XS0004-282X2008000300021http://repositorio.unifesp.br/handle/11600/4394ark:/48912/001300000dm2vengArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T15:13:56Zoai:repositorio.unifesp.br/:11600/4394Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:13:30.602185Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Selective hypothermia: an experimental study on traumatic brain injury in rats Hipotermia seletiva: estudo experimental de traumatismo crânio-encefálico em ratos |
title |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
spellingShingle |
Selective hypothermia: an experimental study on traumatic brain injury in rats Dvilevicius, Amylcar Edemilson [UNIFESP] selective hypothermia hypothermia neuroprotection traumatic brain injury hipotermia seletiva hipotermia neuroproteção traumatismo crânio-encefálico |
title_short |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
title_full |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
title_fullStr |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
title_full_unstemmed |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
title_sort |
Selective hypothermia: an experimental study on traumatic brain injury in rats |
author |
Dvilevicius, Amylcar Edemilson [UNIFESP] |
author_facet |
Dvilevicius, Amylcar Edemilson [UNIFESP] Prandini, Mirto Nelso [UNIFESP] |
author_role |
author |
author2 |
Prandini, Mirto Nelso [UNIFESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Dvilevicius, Amylcar Edemilson [UNIFESP] Prandini, Mirto Nelso [UNIFESP] |
dc.subject.por.fl_str_mv |
selective hypothermia hypothermia neuroprotection traumatic brain injury hipotermia seletiva hipotermia neuroproteção traumatismo crânio-encefálico |
topic |
selective hypothermia hypothermia neuroprotection traumatic brain injury hipotermia seletiva hipotermia neuroproteção traumatismo crânio-encefálico |
description |
OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-06-01 2015-06-14T13:38:34Z 2015-06-14T13:38:34Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-282X2008000300021 Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 2b, p. 391-396, 2008. 10.1590/S0004-282X2008000300021 S0004-282X2008000300021.pdf 0004-282X S0004-282X2008000300021 http://repositorio.unifesp.br/handle/11600/4394 |
dc.identifier.dark.fl_str_mv |
ark:/48912/001300000dm2v |
url |
http://dx.doi.org/10.1590/S0004-282X2008000300021 http://repositorio.unifesp.br/handle/11600/4394 |
identifier_str_mv |
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 2b, p. 391-396, 2008. 10.1590/S0004-282X2008000300021 S0004-282X2008000300021.pdf 0004-282X S0004-282X2008000300021 ark:/48912/001300000dm2v |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
391-396 application/pdf |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia - ABNEURO |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1818602450615009280 |