Selective hypothermia: an experimental study on traumatic brain injury in rats

Detalhes bibliográficos
Autor(a) principal: Dvilevicius, Amylcar Edemilson [UNIFESP]
Data de Publicação: 2008
Outros Autores: Prandini, Mirto Nelso [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000dm2v
Texto Completo: http://dx.doi.org/10.1590/S0004-282X2008000300021
http://repositorio.unifesp.br/handle/11600/4394
Resumo: OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.
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spelling Selective hypothermia: an experimental study on traumatic brain injury in ratsHipotermia seletiva: estudo experimental de traumatismo crânio-encefálico em ratosselective hypothermiahypothermianeuroprotectiontraumatic brain injuryhipotermia seletivahipotermianeuroproteçãotraumatismo crânio-encefálicoOBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.OBJETIVO: Avaliar a eficiência da hipotermia seletiva no tratamento do traumatismo crânio-encefálico (TCe) em ratos. o trauma foi produzido por um modelo de impacto cortical desenvolvido exclusivamente para o estudo. MÉTODO: Após o TCE produzido pelo modelo de impacto cortical, foi realizada pequena craniectomia na região fronto-parietal direita; após o procedimento os animais foram divididos em dois grupos de 15 cada um. o grupo A, sem tratamento com hipotermia (grupo controle) e grupo B, tratado com hipotermia seletiva por período de 5 a 6 horas. depois deste tempo todos os animais foram sacrificados, seus encéfalos foram removidos e realizada a análise anatomopatológica. RESULTADOS: Na comparação entre o grupo tratado com hipotermia e o grupo controle utilizou-se a contagem de neurônios lesados por campo. Tal contagem no grupo A (controle/sem tratamento) com n=15 teve media de 70,80 neurônios lesados por campo contra a media de 21,33 nerônios lesados por campo no grupo B (submetido ao tratamento com hipotermia), com n=15 também. diferença estatísticamente significativa pôde ser demonstrada. CONCLUSÃO: A análise anatomopatológica dos encéfalos dos animais estudados, baseada na quantificação dos neurônios lesados por campo demonstrou efetividade do tratamento com hipotermia seletiva com diferença estatística significativa.Universidade Federal de São Paulo (UNIFESP) EPMUNIFESP, EPMSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Dvilevicius, Amylcar Edemilson [UNIFESP]Prandini, Mirto Nelso [UNIFESP]2015-06-14T13:38:34Z2015-06-14T13:38:34Z2008-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion391-396application/pdfhttp://dx.doi.org/10.1590/S0004-282X2008000300021Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 2b, p. 391-396, 2008.10.1590/S0004-282X2008000300021S0004-282X2008000300021.pdf0004-282XS0004-282X2008000300021http://repositorio.unifesp.br/handle/11600/4394ark:/48912/001300000dm2vengArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T15:13:56Zoai:repositorio.unifesp.br/:11600/4394Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:13:30.602185Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Selective hypothermia: an experimental study on traumatic brain injury in rats
Hipotermia seletiva: estudo experimental de traumatismo crânio-encefálico em ratos
title Selective hypothermia: an experimental study on traumatic brain injury in rats
spellingShingle Selective hypothermia: an experimental study on traumatic brain injury in rats
Dvilevicius, Amylcar Edemilson [UNIFESP]
selective hypothermia
hypothermia
neuroprotection
traumatic brain injury
hipotermia seletiva
hipotermia
neuroproteção
traumatismo crânio-encefálico
title_short Selective hypothermia: an experimental study on traumatic brain injury in rats
title_full Selective hypothermia: an experimental study on traumatic brain injury in rats
title_fullStr Selective hypothermia: an experimental study on traumatic brain injury in rats
title_full_unstemmed Selective hypothermia: an experimental study on traumatic brain injury in rats
title_sort Selective hypothermia: an experimental study on traumatic brain injury in rats
author Dvilevicius, Amylcar Edemilson [UNIFESP]
author_facet Dvilevicius, Amylcar Edemilson [UNIFESP]
Prandini, Mirto Nelso [UNIFESP]
author_role author
author2 Prandini, Mirto Nelso [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Dvilevicius, Amylcar Edemilson [UNIFESP]
Prandini, Mirto Nelso [UNIFESP]
dc.subject.por.fl_str_mv selective hypothermia
hypothermia
neuroprotection
traumatic brain injury
hipotermia seletiva
hipotermia
neuroproteção
traumatismo crânio-encefálico
topic selective hypothermia
hypothermia
neuroprotection
traumatic brain injury
hipotermia seletiva
hipotermia
neuroproteção
traumatismo crânio-encefálico
description OBJECTIVE: To evaluate the efficiency of selective hypothermia in the treatment of the traumatic brain injury in rats. METHOD: After the trauma produced for the model of cortical impact, a small craniectomy in the right frontoparietal region was carried through; after the procedure the animals had been divided in two groups of 15 each. Group A, without treatment with hypothermia (control group) and group B, treated with selective hypothermia for a period to 5 to 6 hours. After this time all the animals were sacrificed, their brains had been removed and histopathological analysis was carried through. RESULTS: Comparison between both groups was done using the counting of neurons injured for field. Counting in the control group n=15 had an average of 70.80 neurons injured for field against an average of 21.33 neurons injured for field in group B (submitted to the treatment with hypothermia), with n=15 also. The difference was statiscally significant. CONCLUSION: Based in the quantification of the neurons injured for field, the effectiveness of the treatment with selective hypothermia was demonstrated.
publishDate 2008
dc.date.none.fl_str_mv 2008-06-01
2015-06-14T13:38:34Z
2015-06-14T13:38:34Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-282X2008000300021
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 2b, p. 391-396, 2008.
10.1590/S0004-282X2008000300021
S0004-282X2008000300021.pdf
0004-282X
S0004-282X2008000300021
http://repositorio.unifesp.br/handle/11600/4394
dc.identifier.dark.fl_str_mv ark:/48912/001300000dm2v
url http://dx.doi.org/10.1590/S0004-282X2008000300021
http://repositorio.unifesp.br/handle/11600/4394
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 66, n. 2b, p. 391-396, 2008.
10.1590/S0004-282X2008000300021
S0004-282X2008000300021.pdf
0004-282X
S0004-282X2008000300021
ark:/48912/001300000dm2v
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 391-396
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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