Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/0004-282X20130076 http://repositorio.unifesp.br/handle/11600/7898 |
Resumo: | Genetic and environmental factors affect the pathogenesis of Parkinson's disease(PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be relatedto the disease. This study aimed to evaluate the influence of genetic variants of GST(GSTT1/GSTM1) and their association with the exposure to environmental toxins in PDpatients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variantwere analyzed by polymerase chain reaction. We applied the Fisher's exact test andthe χ2 test for statistical analysis (p<0.05). The present andabsence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared tocontrols (13%, p=0.014). This study suggests the association between PD and previouexposure to pesticides, whose effect may be enhanced in combination with null forGSTT1/GSTM1. |
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Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's diseaseNulidade de GSTT1/GSTM1 relacionada a pesticidas associa-se com doenca de ParkinsonParkinson diseaseglutathione transferasepolymorphism geneticxenobioticsdoenca de Parkinsonglutationa transferasepolimorfismo geneticoxenobioticosGenetic and environmental factors affect the pathogenesis of Parkinson's disease(PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be relatedto the disease. This study aimed to evaluate the influence of genetic variants of GST(GSTT1/GSTM1) and their association with the exposure to environmental toxins in PDpatients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variantwere analyzed by polymerase chain reaction. We applied the Fisher's exact test andthe χ2 test for statistical analysis (p<0.05). The present andabsence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared tocontrols (13%, p=0.014). This study suggests the association between PD and previouexposure to pesticides, whose effect may be enhanced in combination with null forGSTT1/GSTM1.Fatores genéticos e ambientais influenciam a patogênese da doença de Parkinson (DP).Variantes genéticas das enzimas glutationa S-transferases (GST) parecem estarenvolvidas com a doença. Os objetivos deste estudo foram avaliar a influência devariantes genéticas de GST (GSTT1/GSTM1) e sua associação com exposição a toxinaambientais em pacientes com DP. Foram estudados 254 pacientes com DP e 169 controles.As variantes para GSTM1/GSTT1 foram analisadas por reação em cadeia da polimerase.Para análise estatística foram aplicados os testes de Fisher e do χ2(p<0,05). Tanto a presença quanto a nulidade para GSTT1 e GSTM1 foramsemelhantes em pacientes e controles. A nulidade para GSTT1 e GSTM1 (0/0) e contatocom agrotóxicos prevaleceu nos pacientes (18%) em relação aos controles (13%,p=0,014). Este estudo sugere associação entre DP e contato prévio com agrotóxicos,cujo efeito parece potencializado em combinação com nulidade para GSTT1/GSTM1.FAMERPUniversidade Federal de São Paulo (UNIFESP)FAMERP Department of NeuroscienceFAMERP Hospital de BaseUNIFESPSciELOAcademia Brasileira de Neurologia - ABNEUROFAMERPUniversidade Federal de São Paulo (UNIFESP)FAMERP Department of NeuroscienceFAMERP Hospital de BasePinhel, Marcela Augusta de SouzaSado, Caroline Leiko [UNIFESP]Longo, Gabriela dos SantosGregorio, Michele LimaAmorim, Gisele SousaFlorim, Greiciane Maria da SilvaMazeti, Camila MontoroMartins, Denise PoltronieriOliveira, Fabio de NazareNakazone, Marcelo ArrudaTognola, Waldir AntonioSouza, Dorotéia Rossi Silva2015-06-14T13:45:35Z2015-06-14T13:45:35Z2013-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion527-532application/pdfhttp://dx.doi.org/10.1590/0004-282X20130076Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 71, n. 8, p. 527-532, 2013.10.1590/0004-282X20130076S0004-282X2013000800527.pdf0004-282XS0004-282X2013000800527http://repositorio.unifesp.br/handle/11600/7898engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T12:08:36Zoai:repositorio.unifesp.br/:11600/7898Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T12:08:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease Nulidade de GSTT1/GSTM1 relacionada a pesticidas associa-se com doenca de Parkinson |
| title |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease |
| spellingShingle |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease Pinhel, Marcela Augusta de Souza Parkinson disease glutathione transferase polymorphism genetic xenobiotics doenca de Parkinson glutationa transferase polimorfismo genetico xenobioticos |
| title_short |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease |
| title_full |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease |
| title_fullStr |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease |
| title_full_unstemmed |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease |
| title_sort |
Nullity of GSTT1/GSTM1 related to pesticides is associatedwith Parkinson's disease |
| author |
Pinhel, Marcela Augusta de Souza |
| author_facet |
Pinhel, Marcela Augusta de Souza Sado, Caroline Leiko [UNIFESP] Longo, Gabriela dos Santos Gregorio, Michele Lima Amorim, Gisele Sousa Florim, Greiciane Maria da Silva Mazeti, Camila Montoro Martins, Denise Poltronieri Oliveira, Fabio de Nazare Nakazone, Marcelo Arruda Tognola, Waldir Antonio Souza, Dorotéia Rossi Silva |
| author_role |
author |
| author2 |
Sado, Caroline Leiko [UNIFESP] Longo, Gabriela dos Santos Gregorio, Michele Lima Amorim, Gisele Sousa Florim, Greiciane Maria da Silva Mazeti, Camila Montoro Martins, Denise Poltronieri Oliveira, Fabio de Nazare Nakazone, Marcelo Arruda Tognola, Waldir Antonio Souza, Dorotéia Rossi Silva |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
FAMERP Universidade Federal de São Paulo (UNIFESP) FAMERP Department of Neuroscience FAMERP Hospital de Base |
| dc.contributor.author.fl_str_mv |
Pinhel, Marcela Augusta de Souza Sado, Caroline Leiko [UNIFESP] Longo, Gabriela dos Santos Gregorio, Michele Lima Amorim, Gisele Sousa Florim, Greiciane Maria da Silva Mazeti, Camila Montoro Martins, Denise Poltronieri Oliveira, Fabio de Nazare Nakazone, Marcelo Arruda Tognola, Waldir Antonio Souza, Dorotéia Rossi Silva |
| dc.subject.por.fl_str_mv |
Parkinson disease glutathione transferase polymorphism genetic xenobiotics doenca de Parkinson glutationa transferase polimorfismo genetico xenobioticos |
| topic |
Parkinson disease glutathione transferase polymorphism genetic xenobiotics doenca de Parkinson glutationa transferase polimorfismo genetico xenobioticos |
| description |
Genetic and environmental factors affect the pathogenesis of Parkinson's disease(PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be relatedto the disease. This study aimed to evaluate the influence of genetic variants of GST(GSTT1/GSTM1) and their association with the exposure to environmental toxins in PDpatients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variantwere analyzed by polymerase chain reaction. We applied the Fisher's exact test andthe χ2 test for statistical analysis (p<0.05). The present andabsence for GSTT1 and GSTM1 were similar in patients and controls. The null for GSTT1and GSTM1 (0/0) and exposure to pesticides prevailed in patients (18%) compared tocontrols (13%, p=0.014). This study suggests the association between PD and previouexposure to pesticides, whose effect may be enhanced in combination with null forGSTT1/GSTM1. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013-08-01 2015-06-14T13:45:35Z 2015-06-14T13:45:35Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0004-282X20130076 Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 71, n. 8, p. 527-532, 2013. 10.1590/0004-282X20130076 S0004-282X2013000800527.pdf 0004-282X S0004-282X2013000800527 http://repositorio.unifesp.br/handle/11600/7898 |
| url |
http://dx.doi.org/10.1590/0004-282X20130076 http://repositorio.unifesp.br/handle/11600/7898 |
| identifier_str_mv |
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 71, n. 8, p. 527-532, 2013. 10.1590/0004-282X20130076 S0004-282X2013000800527.pdf 0004-282X S0004-282X2013000800527 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Arquivos de Neuro-Psiquiatria |
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info:eu-repo/semantics/openAccess |
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openAccess |
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527-532 application/pdf |
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Academia Brasileira de Neurologia - ABNEURO |
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Academia Brasileira de Neurologia - ABNEURO |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268360749219840 |