A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats

Detalhes bibliográficos
Autor(a) principal: Pereira, João S. [UNIFESP]
Data de Publicação: 1992
Outros Autores: Bertolucci, Paulo Henrique Ferreira [UNIFESP], Ferraz, Henrique B. [UNIFESP], Andrade, Luiz A. F. De [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-282X1992000300001
http://repositorio.unifesp.br/handle/11600/304
Resumo: Tardive dyskinesia (TD), a serious complications of neuroleptic chronic use, has no effective therapy yet. We performed an experiment to study the action on TD, of the calcium channel blockers (CCB) drugs, verapamil and flunarizine. We obtained the TD model in rats, administering haloperidol for a 21-day period. After this, the stereotyped movement induced by apomorphyne was rated. The CCB drugs were administered in acute (in the 28th. day) and chronic (for 8 days, after the 25th day) experiments. Acutely, verapamil increased the stereotyped behaviour, and promoted a reduction of it in the chronic experiment. The results suggest that CCB drugs should be tested in clinical trials of TD.
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spelling A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in ratsEstudo da ação de dois bloqueadores de canais de cálcio sobre modelo experimental de discinesia tardia em ratostardive dyskinesiacalcium channel blockers drugsneurolepticsdiscinesia tardiadrogas bloqueadoras de canais de cálcioneuro-lépticosTardive dyskinesia (TD), a serious complications of neuroleptic chronic use, has no effective therapy yet. We performed an experiment to study the action on TD, of the calcium channel blockers (CCB) drugs, verapamil and flunarizine. We obtained the TD model in rats, administering haloperidol for a 21-day period. After this, the stereotyped movement induced by apomorphyne was rated. The CCB drugs were administered in acute (in the 28th. day) and chronic (for 8 days, after the 25th day) experiments. Acutely, verapamil increased the stereotyped behaviour, and promoted a reduction of it in the chronic experiment. The results suggest that CCB drugs should be tested in clinical trials of TD.A discinesia tardia (DT) é complicação decorrente do uso prolongado de neuro-lépticos. Até o presente, nenhum tratamento provou ser eficaz na DT. Evidências indiretas apontam para a ação de drogas bloqueadoras de canais de cálcio (BCC) em algumas vias neurais. A ação de duas dessas drogas, verapamil e flunarizina, foi testada em modelo experimental de DT em rato, neste estudo. O haloperidol foi administrado por 21 dias e indução de movimentos estereotipados era obtida no 24º dia, com a injeção de apomorfina. As drogas BCC foram administradas por uma vez no 28º dia (experimento agudo) e por 8 dias, após o 25º dia (experimento crônico). A flunarizina não induziu modificação no padrão de estereotipia dos animais, mas o verapamil levou a aumento no experimento agudo e a diminuição no experimento crônico. Estes achados indicam que as drogas BCC podem ter alguma ação sobre a DT e que ensaios clínicos devem ser feitos para se comprovar se tal ação ocorre no homem.Escola Paulista de Medicina Department of Neurology and Neurosurgery Sector for Investigation of Extrapyradimal DiseasesUNIFESP, EPM, Department of Neurology and Neurosurgery Sector for Investigation of Extrapyradimal DiseasesSciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Pereira, João S. [UNIFESP]Bertolucci, Paulo Henrique Ferreira [UNIFESP]Ferraz, Henrique B. [UNIFESP]Andrade, Luiz A. F. De [UNIFESP]2015-06-14T13:24:23Z2015-06-14T13:24:23Z1992-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion263-268application/pdfhttp://dx.doi.org/10.1590/S0004-282X1992000300001Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 50, n. 3, p. 263-268, 1992.10.1590/S0004-282X1992000300001S0004-282X1992000300001.pdf0004-282XS0004-282X1992000300001http://repositorio.unifesp.br/handle/11600/304engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T17:30:51Zoai:repositorio.unifesp.br/:11600/304Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T17:30:51Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
Estudo da ação de dois bloqueadores de canais de cálcio sobre modelo experimental de discinesia tardia em ratos
title A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
spellingShingle A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
Pereira, João S. [UNIFESP]
tardive dyskinesia
calcium channel blockers drugs
neuroleptics
discinesia tardia
drogas bloqueadoras de canais de cálcio
neuro-lépticos
title_short A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
title_full A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
title_fullStr A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
title_full_unstemmed A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
title_sort A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats
author Pereira, João S. [UNIFESP]
author_facet Pereira, João S. [UNIFESP]
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Ferraz, Henrique B. [UNIFESP]
Andrade, Luiz A. F. De [UNIFESP]
author_role author
author2 Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Ferraz, Henrique B. [UNIFESP]
Andrade, Luiz A. F. De [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Pereira, João S. [UNIFESP]
Bertolucci, Paulo Henrique Ferreira [UNIFESP]
Ferraz, Henrique B. [UNIFESP]
Andrade, Luiz A. F. De [UNIFESP]
dc.subject.por.fl_str_mv tardive dyskinesia
calcium channel blockers drugs
neuroleptics
discinesia tardia
drogas bloqueadoras de canais de cálcio
neuro-lépticos
topic tardive dyskinesia
calcium channel blockers drugs
neuroleptics
discinesia tardia
drogas bloqueadoras de canais de cálcio
neuro-lépticos
description Tardive dyskinesia (TD), a serious complications of neuroleptic chronic use, has no effective therapy yet. We performed an experiment to study the action on TD, of the calcium channel blockers (CCB) drugs, verapamil and flunarizine. We obtained the TD model in rats, administering haloperidol for a 21-day period. After this, the stereotyped movement induced by apomorphyne was rated. The CCB drugs were administered in acute (in the 28th. day) and chronic (for 8 days, after the 25th day) experiments. Acutely, verapamil increased the stereotyped behaviour, and promoted a reduction of it in the chronic experiment. The results suggest that CCB drugs should be tested in clinical trials of TD.
publishDate 1992
dc.date.none.fl_str_mv 1992-09-01
2015-06-14T13:24:23Z
2015-06-14T13:24:23Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-282X1992000300001
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 50, n. 3, p. 263-268, 1992.
10.1590/S0004-282X1992000300001
S0004-282X1992000300001.pdf
0004-282X
S0004-282X1992000300001
http://repositorio.unifesp.br/handle/11600/304
url http://dx.doi.org/10.1590/S0004-282X1992000300001
http://repositorio.unifesp.br/handle/11600/304
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 50, n. 3, p. 263-268, 1992.
10.1590/S0004-282X1992000300001
S0004-282X1992000300001.pdf
0004-282X
S0004-282X1992000300001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 263-268
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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