Avaliação do perfil metabólico, nutricional e efeitos adversos de crianças com epilepsia refratária em uso da dieta cetogênica

• Autor(a) principal: Rizzutti, Sueli [UNIFESP]
• Data de Publicação: 2006
• Outros Autores: Ramos, Ana Maria Figueiredo [UNIFESP], Cintra, Isa de Pádua [UNIFESP], Muszkat, Mauro [UNIFESP], Gabbai, Alberto Alain [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S1415-52732006000500005; http://repositorio.unifesp.br/handle/11600/3311
• topic: child; diet; effects; epilepsy; dietary fats; criança; dieta; epilepsia; lipídeos na dieta

OBJECTIVE: The purpose of this research was to evaluate adverse events, serum biochemistry, growth and nutritional status of children with difficult-to-control seizures who were submitted to ketogenic diet. METHODS: Twenty-three patients aging from 2 to 17 years with refractory epilepsies, where 43.5% (n=10) were males and 56.5% (n=13) females from the Sector of Neuropediatrics, Discipline of Neurology of the Universidade Federal de São Paulo (UNIFESP), were treated with the ketogenic diet and followed up for at least 1 year. Two patients were not able to achieve persistent ketosis either because they rejected the diets or their parents did not comply. RESULTS: Adverse events were all reversible and included hyperlipidemia, constipation (17.4%), nausea and vomiting (43.4%), drowsiness (47.8%), intercurrent infections (3.0%), diet refusal (13.0%) and epistaxis (4.3%). Growth was not affected in the short term and most heights remained within the normal centile lines. CONCLUSION: The ketogenic diet can be considered a safe and effective treatment for children with intractable seizures.