Assessment of serum biochemistry, nutritional status and adverse effects of children with refractory epilepsy using the ketogenic diet

• Autor(a) principal: RIZZUTTI, Sueli
• Data de Publicação: 2023
• Outros Autores: Figueiredo RAMOS, Ana Maria, CINTRA, Isa de Pádua, MUSZKAT, Mauro, Alain GABBAI, Alberto
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9747
• topic: child; diet; effects; epilepsy; dietary fats; criança; dieta; epilepsia; lipídeos na dieta

ObjectiveThe purpose of this research was to evaluate adverse events, serum biochemistry, growth and nutritional status of children with difficult-to-control seizures who were submitted to ketogenic diet. MethodsTwenty-three patients aging from 2 to 17 years with refractory epilepsies, where 43.5% (n=10) were males and56.5% (n=13) females from the Sector of Neuropediatrics, Discipline of Neurology of the Universidade Federalde São Paulo, were treated with the ketogenic diet and followed up for at least 1 year. Two patients were notable to achieve persistent ketosis either because they rejected the diets or their parents did not comply. ResultsAdverse events were all reversible and included hyperlipidemia, constipation (17.4%), nausea and vomiting (43.4%), drowsiness (47.8%), intercurrent infections (3.0%), diet refusal (13.0%) and epistaxis (4.3%). Growthwas not affected in the short term and most heights remained within the normal centile lines. ConclusionThe ketogenic diet can be considered a safe and effective treatment for children with intractable seizures.