Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54470 http://dx.doi.org/10.1371/journal.pone.0177032 |
Resumo: | Background Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). Methods We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as % predicted/y (% P/y) and % of baseline/y (% B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. Results Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bron-chodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or >= 2 respiratory exacerbations in the previous year, and in men with asthma. Conclusions Lung function decline in a population- based cohort did not differ in obstructed and nonobstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms. |
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Perez-Padilla, RogelioFernandez-Plata, RosarioMontes de Oca, MariaVictorina Lopez-Varela, MariaJardim, Jose R. [UNIFESP]Muino, AdrianaValdivia, GonzaloMenezes, Ana Maria B.2020-07-13T11:53:14Z2020-07-13T11:53:14Z2017Plos One. San Francisco, v. 12, n. 5, p. -, 2017.1932-6203https://repositorio.unifesp.br/handle/11600/54470http://dx.doi.org/10.1371/journal.pone.0177032WOS000401314500003.pdfhttp://dx.doi.org/10.1371/journal.pone.0177032WOS:000400648500124Background Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). Methods We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as % predicted/y (% P/y) and % of baseline/y (% B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. Results Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bron-chodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or >= 2 respiratory exacerbations in the previous year, and in men with asthma. Conclusions Lung function decline in a population- based cohort did not differ in obstructed and nonobstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms.ALATBoehringerGSKNovartisNatl Inst Resp Dis, Mexico City, DF, MexicoUniv Cent Venezuela, Hosp Univ Caracas, Pulm Div, Caracas, VenezuelaUniv Republica, Fac Med, Montevideo, UruguayUniv Fed Sao Paulo, Sch Med, São Paulo, BrazilUniv Fed Pelotas, Postgrad Program Epidemiol, Pelotas, BrazilUniv Fed Sao Paulo, Sch Med, São Paulo, BrazilWeb of Science-engPublic Library SciencePlos OneLung function decline in subjects with and without COPD in a population-based cohort in Latin-Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSan Francisco125info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/544702021-10-05 21:59:10.442metadata only accessoai:repositorio.unifesp.br:11600/54470Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:59:10Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America |
title |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America |
spellingShingle |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America Perez-Padilla, Rogelio |
title_short |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America |
title_full |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America |
title_fullStr |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America |
title_full_unstemmed |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America |
title_sort |
Lung function decline in subjects with and without COPD in a population-based cohort in Latin-America |
author |
Perez-Padilla, Rogelio |
author_facet |
Perez-Padilla, Rogelio Fernandez-Plata, Rosario Montes de Oca, Maria Victorina Lopez-Varela, Maria Jardim, Jose R. [UNIFESP] Muino, Adriana Valdivia, Gonzalo Menezes, Ana Maria B. |
author_role |
author |
author2 |
Fernandez-Plata, Rosario Montes de Oca, Maria Victorina Lopez-Varela, Maria Jardim, Jose R. [UNIFESP] Muino, Adriana Valdivia, Gonzalo Menezes, Ana Maria B. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Perez-Padilla, Rogelio Fernandez-Plata, Rosario Montes de Oca, Maria Victorina Lopez-Varela, Maria Jardim, Jose R. [UNIFESP] Muino, Adriana Valdivia, Gonzalo Menezes, Ana Maria B. |
description |
Background Lung-function decline is one of the possible mechanisms leading to Chronic Obstructive Pulmonary Disease (COPD). Methods We analyzed data obtained from two population-based surveys of adults (n = 2026) conducted in the same individuals 5-9 years (y) after their baseline examination in three Latin-American cities. Post BronchoDilator (postBD) FEV1 decline in mL/y, as % predicted/y (% P/y) and % of baseline/y (% B/y) was calculated and the influence of age, gender, BMI, baseline lung function, BD response, exacerbations rate evaluated using multivariate models. Results Expressed in ml/y, the mean annual postBD FEV1 decline was 27 mL (0.22%P, 1.32%B) in patients with baseline COPD and 36 (0.14%P, 1.36%B) in those without. Faster decline (in mL/y) was associated with higher baseline lung function, with significant response to bron-chodilators, older age and smoking at baseline, also in women with chronic cough and phlegm, or >= 2 respiratory exacerbations in the previous year, and in men with asthma. Conclusions Lung function decline in a population- based cohort did not differ in obstructed and nonobstructed individuals, it was proportional to baseline FEV1, and was higher in smokers, elderly, and women with respiratory symptoms. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-07-13T11:53:14Z |
dc.date.available.fl_str_mv |
2020-07-13T11:53:14Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Plos One. San Francisco, v. 12, n. 5, p. -, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54470 http://dx.doi.org/10.1371/journal.pone.0177032 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
dc.identifier.file.none.fl_str_mv |
WOS000401314500003.pdf |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0177032 |
dc.identifier.wos.none.fl_str_mv |
WOS:000400648500124 |
identifier_str_mv |
Plos One. San Francisco, v. 12, n. 5, p. -, 2017. 1932-6203 WOS000401314500003.pdf WOS:000400648500124 |
url |
https://repositorio.unifesp.br/handle/11600/54470 http://dx.doi.org/10.1371/journal.pone.0177032 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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Plos One |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- |
dc.coverage.none.fl_str_mv |
San Francisco |
dc.publisher.none.fl_str_mv |
Public Library Science |
publisher.none.fl_str_mv |
Public Library Science |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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1802764164981063680 |