Chagas' disease: an update on immune mechanisms and therapeutic strategies
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1111/j.1582-4934.2010.01007.x http://repositorio.unifesp.br/handle/11600/32564 |
Resumo: | The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. in the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system. |
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Chagas' disease: an update on immune mechanisms and therapeutic strategiesChagas' diseaseTrypanosoma cruziimmunitychemotherapyimmunoparasitologyThe final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. in the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.Univ São Paulo, Inst Biomed Sci, Dept Parasitol, São Paulo, BrazilMackenzie Presbeterian Univ, Ctr Biomol Sci & Hlth, São Paulo, BrazilNatl Univ Rosario, Sch Med Sci, Inst Immunol, Rosario, Santa Fe, ArgentinaCSIC, Inst Parasitol & Biomed Lopez Neyra, Granada, SpainUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto Nacional de Biologia Estrutural e QuImica Medicinal em Doencas Infecciosas (INBEQMeDI)FAPESP: 08/57596-4FAPESP: 07/08648-9CNPq: 473906/2008-2Wiley-BlackwellUniversidade de São Paulo (USP)Mackenzie Presbeterian UnivNatl Univ RosarioCSICUniversidade Federal de São Paulo (UNIFESP)Boscardin, Silvia BeatrizTroccoli Torrecilhas, Ana ClaudiaManarin, RominaRevelli, SilviaGonzalez Rey, ElenaTonelli, Renata Rosito [UNIFESP]Silber, Ariel Mariano2016-01-24T13:59:43Z2016-01-24T13:59:43Z2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1373-1384application/pdfhttp://dx.doi.org/10.1111/j.1582-4934.2010.01007.xJournal of Cellular and Molecular Medicine. Malden: Wiley-Blackwell, v. 14, n. 6B, p. 1373-1384, 2010.10.1111/j.1582-4934.2010.01007.xWOS000292023100001.pdf1582-1838http://repositorio.unifesp.br/handle/11600/32564WOS:000292023100001engJournal of Cellular and Molecular Medicineinfo:eu-repo/semantics/openAccesshttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T07:11:32Zoai:repositorio.unifesp.br/:11600/32564Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T07:11:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Chagas' disease: an update on immune mechanisms and therapeutic strategies |
| title |
Chagas' disease: an update on immune mechanisms and therapeutic strategies |
| spellingShingle |
Chagas' disease: an update on immune mechanisms and therapeutic strategies Boscardin, Silvia Beatriz Chagas' disease Trypanosoma cruzi immunity chemotherapy immunoparasitology |
| title_short |
Chagas' disease: an update on immune mechanisms and therapeutic strategies |
| title_full |
Chagas' disease: an update on immune mechanisms and therapeutic strategies |
| title_fullStr |
Chagas' disease: an update on immune mechanisms and therapeutic strategies |
| title_full_unstemmed |
Chagas' disease: an update on immune mechanisms and therapeutic strategies |
| title_sort |
Chagas' disease: an update on immune mechanisms and therapeutic strategies |
| author |
Boscardin, Silvia Beatriz |
| author_facet |
Boscardin, Silvia Beatriz Troccoli Torrecilhas, Ana Claudia Manarin, Romina Revelli, Silvia Gonzalez Rey, Elena Tonelli, Renata Rosito [UNIFESP] Silber, Ariel Mariano |
| author_role |
author |
| author2 |
Troccoli Torrecilhas, Ana Claudia Manarin, Romina Revelli, Silvia Gonzalez Rey, Elena Tonelli, Renata Rosito [UNIFESP] Silber, Ariel Mariano |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Mackenzie Presbeterian Univ Natl Univ Rosario CSIC Universidade Federal de São Paulo (UNIFESP) |
| dc.contributor.author.fl_str_mv |
Boscardin, Silvia Beatriz Troccoli Torrecilhas, Ana Claudia Manarin, Romina Revelli, Silvia Gonzalez Rey, Elena Tonelli, Renata Rosito [UNIFESP] Silber, Ariel Mariano |
| dc.subject.por.fl_str_mv |
Chagas' disease Trypanosoma cruzi immunity chemotherapy immunoparasitology |
| topic |
Chagas' disease Trypanosoma cruzi immunity chemotherapy immunoparasitology |
| description |
The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. in the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system. |
| publishDate |
2010 |
| dc.date.none.fl_str_mv |
2010-06-01 2016-01-24T13:59:43Z 2016-01-24T13:59:43Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1582-4934.2010.01007.x Journal of Cellular and Molecular Medicine. Malden: Wiley-Blackwell, v. 14, n. 6B, p. 1373-1384, 2010. 10.1111/j.1582-4934.2010.01007.x WOS000292023100001.pdf 1582-1838 http://repositorio.unifesp.br/handle/11600/32564 WOS:000292023100001 |
| url |
http://dx.doi.org/10.1111/j.1582-4934.2010.01007.x http://repositorio.unifesp.br/handle/11600/32564 |
| identifier_str_mv |
Journal of Cellular and Molecular Medicine. Malden: Wiley-Blackwell, v. 14, n. 6B, p. 1373-1384, 2010. 10.1111/j.1582-4934.2010.01007.x WOS000292023100001.pdf 1582-1838 WOS:000292023100001 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Journal of Cellular and Molecular Medicine |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
| dc.format.none.fl_str_mv |
1373-1384 application/pdf |
| dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
| publisher.none.fl_str_mv |
Wiley-Blackwell |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1824718157286211584 |