Malaria vaccine: roadblocks and possible solutions
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/601 http://dx.doi.org/10.1590/S0100-879X1998000300002 |
Resumo: | Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant proteins that are being extensively used in experimental immunizations against the infection. Today, several epitopes of limited polymorphism have been described and protective immunity can be generated by immunization with them. These epitopes are being tested as primary candidates for a subunit vaccine against malaria. Here we critically review the major roadblocks for the development of a malaria vaccine and provide some insight on how these problems are being solved |
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Soares, Irene da Silva [UNIFESP]Rodrigues, Mauricio Martins [UNIFESP]Universidade Federal do ParáUniversidade Federal de São Paulo (UNIFESP)2015-06-14T13:24:43Z2015-06-14T13:24:43Z1998-03-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 3, p. 317-332, 1998.0100-879Xhttp://repositorio.unifesp.br/handle/11600/601http://dx.doi.org/10.1590/S0100-879X1998000300002S0100-879X1998000300002.pdfS0100-879X199800030000210.1590/S0100-879X1998000300002WOS:000073337200002Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant proteins that are being extensively used in experimental immunizations against the infection. Today, several epitopes of limited polymorphism have been described and protective immunity can be generated by immunization with them. These epitopes are being tested as primary candidates for a subunit vaccine against malaria. Here we critically review the major roadblocks for the development of a malaria vaccine and provide some insight on how these problems are being solvedUniversidade Federal do ParáUniversidade Federal de São Paulo (UNIFESP)Universidade Federal de São Paulo, EPM, São Paulo, BrazilSciELO317-332engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchmalariaPlasmodiumvaccineimmunityinfectious diseaseMalaria vaccine: roadblocks and possible solutionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X1998000300002.pdfapplication/pdf90736${dspace.ui.url}/bitstream/11600/601/1/S0100-879X1998000300002.pdff2a6171d9cefd4c2c03e7d115073930bMD51open accessTEXTS0100-879X1998000300002.pdf.txtS0100-879X1998000300002.pdf.txtExtracted texttext/plain63346${dspace.ui.url}/bitstream/11600/601/2/S0100-879X1998000300002.pdf.txt74587cfd362deec00ea7ef8f650f8decMD52open access11600/6012022-11-04 14:18:47.591open accessoai:repositorio.unifesp.br:11600/601Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-04T17:18:47Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Malaria vaccine: roadblocks and possible solutions |
title |
Malaria vaccine: roadblocks and possible solutions |
spellingShingle |
Malaria vaccine: roadblocks and possible solutions Soares, Irene da Silva [UNIFESP] malaria Plasmodium vaccine immunity infectious disease |
title_short |
Malaria vaccine: roadblocks and possible solutions |
title_full |
Malaria vaccine: roadblocks and possible solutions |
title_fullStr |
Malaria vaccine: roadblocks and possible solutions |
title_full_unstemmed |
Malaria vaccine: roadblocks and possible solutions |
title_sort |
Malaria vaccine: roadblocks and possible solutions |
author |
Soares, Irene da Silva [UNIFESP] |
author_facet |
Soares, Irene da Silva [UNIFESP] Rodrigues, Mauricio Martins [UNIFESP] |
author_role |
author |
author2 |
Rodrigues, Mauricio Martins [UNIFESP] |
author2_role |
author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal do Pará Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Soares, Irene da Silva [UNIFESP] Rodrigues, Mauricio Martins [UNIFESP] |
dc.subject.eng.fl_str_mv |
malaria Plasmodium vaccine immunity infectious disease |
topic |
malaria Plasmodium vaccine immunity infectious disease |
description |
Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant proteins that are being extensively used in experimental immunizations against the infection. Today, several epitopes of limited polymorphism have been described and protective immunity can be generated by immunization with them. These epitopes are being tested as primary candidates for a subunit vaccine against malaria. Here we critically review the major roadblocks for the development of a malaria vaccine and provide some insight on how these problems are being solved |
publishDate |
1998 |
dc.date.issued.fl_str_mv |
1998-03-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:24:43Z |
dc.date.available.fl_str_mv |
2015-06-14T13:24:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 3, p. 317-332, 1998. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/601 http://dx.doi.org/10.1590/S0100-879X1998000300002 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X1998000300002.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X1998000300002 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X1998000300002 |
dc.identifier.wos.none.fl_str_mv |
WOS:000073337200002 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 3, p. 317-332, 1998. 0100-879X S0100-879X1998000300002.pdf S0100-879X1998000300002 10.1590/S0100-879X1998000300002 WOS:000073337200002 |
url |
http://repositorio.unifesp.br/handle/11600/601 http://dx.doi.org/10.1590/S0100-879X1998000300002 |
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eng |
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eng |
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Brazilian Journal of Medical and Biological Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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317-332 |
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Associação Brasileira de Divulgação Científica |
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Associação Brasileira de Divulgação Científica |
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