Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1413-86702003000500011 http://repositorio.unifesp.br/handle/11600/1868 |
Resumo: | We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV. |
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Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virusGlomerulonephritishepatitis CinterferonribavirinWe describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV.Federal University of São Paulo São Paulo Medical School Department of MedicineUNIFESP, EPM, Department of MedicineSciELOBrazilian Society of Infectious DiseasesUniversidade Federal de São Paulo (UNIFESP)Lopes, Edmundo P.a. [UNIFESP]Valente, Lucila M. [UNIFESP]Silva, Antonio Eduardo Benedito [UNIFESP]Mastroianni Kirsztajn, Gianna [UNIFESP]Cruz, Cibele N. [UNIFESP]Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]2015-06-14T13:30:09Z2015-06-14T13:30:09Z2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion353-357application/pdfhttp://dx.doi.org/10.1590/S1413-86702003000500011Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 353-357, 2003.10.1590/S1413-86702003000500011S1413-86702003000500011.pdf1413-8670S1413-86702003000500011http://repositorio.unifesp.br/handle/11600/1868engBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T05:22:56Zoai:repositorio.unifesp.br/:11600/1868Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T05:22:56Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
title |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
spellingShingle |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus Lopes, Edmundo P.a. [UNIFESP] Glomerulonephritis hepatitis C interferon ribavirin |
title_short |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
title_full |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
title_fullStr |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
title_full_unstemmed |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
title_sort |
Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus |
author |
Lopes, Edmundo P.a. [UNIFESP] |
author_facet |
Lopes, Edmundo P.a. [UNIFESP] Valente, Lucila M. [UNIFESP] Silva, Antonio Eduardo Benedito [UNIFESP] Mastroianni Kirsztajn, Gianna [UNIFESP] Cruz, Cibele N. [UNIFESP] Ferraz, Maria Lucia Cardoso Gomes [UNIFESP] |
author_role |
author |
author2 |
Valente, Lucila M. [UNIFESP] Silva, Antonio Eduardo Benedito [UNIFESP] Mastroianni Kirsztajn, Gianna [UNIFESP] Cruz, Cibele N. [UNIFESP] Ferraz, Maria Lucia Cardoso Gomes [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Lopes, Edmundo P.a. [UNIFESP] Valente, Lucila M. [UNIFESP] Silva, Antonio Eduardo Benedito [UNIFESP] Mastroianni Kirsztajn, Gianna [UNIFESP] Cruz, Cibele N. [UNIFESP] Ferraz, Maria Lucia Cardoso Gomes [UNIFESP] |
dc.subject.por.fl_str_mv |
Glomerulonephritis hepatitis C interferon ribavirin |
topic |
Glomerulonephritis hepatitis C interferon ribavirin |
description |
We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-10-01 2015-06-14T13:30:09Z 2015-06-14T13:30:09Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1413-86702003000500011 Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 353-357, 2003. 10.1590/S1413-86702003000500011 S1413-86702003000500011.pdf 1413-8670 S1413-86702003000500011 http://repositorio.unifesp.br/handle/11600/1868 |
url |
http://dx.doi.org/10.1590/S1413-86702003000500011 http://repositorio.unifesp.br/handle/11600/1868 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 353-357, 2003. 10.1590/S1413-86702003000500011 S1413-86702003000500011.pdf 1413-8670 S1413-86702003000500011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
353-357 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268303037693952 |