Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus

Detalhes bibliográficos
Autor(a) principal: Lopes, Edmundo P.a. [UNIFESP]
Data de Publicação: 2003
Outros Autores: Valente, Lucila M. [UNIFESP], Silva, Antonio Eduardo Benedito [UNIFESP], Mastroianni Kirsztajn, Gianna [UNIFESP], Cruz, Cibele N. [UNIFESP], Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1413-86702003000500011
http://repositorio.unifesp.br/handle/11600/1868
Resumo: We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV.
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spelling Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virusGlomerulonephritishepatitis CinterferonribavirinWe describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV.Federal University of São Paulo São Paulo Medical School Department of MedicineUNIFESP, EPM, Department of MedicineSciELOBrazilian Society of Infectious DiseasesUniversidade Federal de São Paulo (UNIFESP)Lopes, Edmundo P.a. [UNIFESP]Valente, Lucila M. [UNIFESP]Silva, Antonio Eduardo Benedito [UNIFESP]Mastroianni Kirsztajn, Gianna [UNIFESP]Cruz, Cibele N. [UNIFESP]Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]2015-06-14T13:30:09Z2015-06-14T13:30:09Z2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion353-357application/pdfhttp://dx.doi.org/10.1590/S1413-86702003000500011Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 353-357, 2003.10.1590/S1413-86702003000500011S1413-86702003000500011.pdf1413-8670S1413-86702003000500011http://repositorio.unifesp.br/handle/11600/1868engBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T05:22:56Zoai:repositorio.unifesp.br/:11600/1868Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T05:22:56Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
title Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
spellingShingle Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
Lopes, Edmundo P.a. [UNIFESP]
Glomerulonephritis
hepatitis C
interferon
ribavirin
title_short Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
title_full Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
title_fullStr Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
title_full_unstemmed Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
title_sort Therapy with interferon-alpha plus ribavirin for membranoproliferative glomerulonephritis induced by hepatitis C virus
author Lopes, Edmundo P.a. [UNIFESP]
author_facet Lopes, Edmundo P.a. [UNIFESP]
Valente, Lucila M. [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
Mastroianni Kirsztajn, Gianna [UNIFESP]
Cruz, Cibele N. [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
author_role author
author2 Valente, Lucila M. [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
Mastroianni Kirsztajn, Gianna [UNIFESP]
Cruz, Cibele N. [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Lopes, Edmundo P.a. [UNIFESP]
Valente, Lucila M. [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
Mastroianni Kirsztajn, Gianna [UNIFESP]
Cruz, Cibele N. [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
dc.subject.por.fl_str_mv Glomerulonephritis
hepatitis C
interferon
ribavirin
topic Glomerulonephritis
hepatitis C
interferon
ribavirin
description We describe a treatment made with interferon-alpha (IFN-alpha) plus ribavirin of two patients with membranoproliferative glomerulonephritis (MPGN) induced by hepatitis C virus (HCV): Case 1 was a 22-year-old woman with leg and facial edema, hypertension and proteinuria, whose liver biopsy revealed chronic active hepatitis; and Case 2 was a 42-year-old man with anasarca, hypertension and proteinuria, whose liver biopsy indicated cirrhosis. Both had anti-HCV, HCV-RNA and cryoglobulins. IFN-alpha (3 million units (MU), 3 times/week) and ribavirin (1 g/day) were administered for 12 months. The drugs were well tolerated by both patients. Serum alanine aminotransferase (ALT) levels normalized and HCV-RNA became negative. Cryoglobulins disappeared and an improvement in renal disease was seen after 6 months of therapy. However, after 9 months, Case 2 presented ALT elevation, and proteinuria was detected. Two years after the end of therapy, both patients were negative in repeated HCV-RNA and cryoglobulin tests. Case 1 was asymptomatic, with normal liver and renal tests, and Case 2 had normal blood pressure, with mild edema of the ankles. Based on the evolution of these two cases, the association of IFN-alpha and ribavirin may be a therapeutic option for patients with MPGN related to HCV.
publishDate 2003
dc.date.none.fl_str_mv 2003-10-01
2015-06-14T13:30:09Z
2015-06-14T13:30:09Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1413-86702003000500011
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 353-357, 2003.
10.1590/S1413-86702003000500011
S1413-86702003000500011.pdf
1413-8670
S1413-86702003000500011
http://repositorio.unifesp.br/handle/11600/1868
url http://dx.doi.org/10.1590/S1413-86702003000500011
http://repositorio.unifesp.br/handle/11600/1868
identifier_str_mv Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 353-357, 2003.
10.1590/S1413-86702003000500011
S1413-86702003000500011.pdf
1413-8670
S1413-86702003000500011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Infectious Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 353-357
application/pdf
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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