Genetics of diabetic nephropathy

Detalhes bibliográficos
Autor(a) principal: Carpena, Mariana P.
Data de Publicação: 2010
Outros Autores: Rados, Dimitris V., Sortica, Denise A., Souza, Bianca M. De, Reis, André Fernandes [UNIFESP], Canani, Luis Henrique, Crispim, Daisy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0004-27302010000300002
http://repositorio.unifesp.br/handle/11600/5624
Resumo: The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.
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spelling Genetics of diabetic nephropathyBases genéticas da nefropatia diabéticaNephropathydiabetes mellitusgeneticsgenetic predispositionNefropatiadiabetes melitogenéticapredisposição genéticaThe increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.A crescente elevação na prevalência do diabetes melito (DM) acarretou em um aumento de suas complicações crônicas, entre elas a nefropatia diabética (ND). Além da elevada prevalência, a ND está associada à importante morbidade e mortalidade, principalmente por doenças cardiovasculares. É notória a contribuição genética na patogênese da ND, em que, na presença de fatores ambientais propícios, aqueles indivíduos geneticamente predispostos desenvolverão a doença. Trata-se de uma doença com provável transmissão genética do tipo poligênica e complexa. Duas estratégias principais têm sido utilizadas na busca dos genes associados à ND: a avaliação de genes candidatos e, mais recentemente, a utilização de genoma wide scan. Grande empenho tem sido realizado para identificar os principais genes associados à ND, mas os resultados ainda são heterogêneos com diferentes genes apresentando um efeito pequeno em populações específicas. A identificação dos principais genes permitiria prever os indivíduos de maior risco para o desenvolvimento da ND, além de possibilitar um melhor entendimento fisiopatológico da doença.Hospital de Clínicas de Porto Alegre Serviço de EndocrinologiaUniversidade Federal do Rio Grande do SulUniversidade Federal de São Paulo (UNIFESP)UNIFESPSciELOSociedade Brasileira de Endocrinologia e MetabologiaHospital de Clínicas de Porto Alegre Serviço de EndocrinologiaUniversidade Federal do Rio Grande do SulUniversidade Federal de São Paulo (UNIFESP)Carpena, Mariana P.Rados, Dimitris V.Sortica, Denise A.Souza, Bianca M. DeReis, André Fernandes [UNIFESP]Canani, Luis HenriqueCrispim, Daisy2015-06-14T13:41:33Z2015-06-14T13:41:33Z2010-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion253-261application/pdfhttp://dx.doi.org/10.1590/S0004-27302010000300002Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 54, n. 3, p. 253-261, 2010.10.1590/S0004-27302010000300002S0004-27302010000300002.pdf0004-2730S0004-27302010000300002http://repositorio.unifesp.br/handle/11600/5624engArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-04T23:55:58Zoai:repositorio.unifesp.br/:11600/5624Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-04T23:55:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Genetics of diabetic nephropathy
Bases genéticas da nefropatia diabética
title Genetics of diabetic nephropathy
spellingShingle Genetics of diabetic nephropathy
Carpena, Mariana P.
Nephropathy
diabetes mellitus
genetics
genetic predisposition
Nefropatia
diabetes melito
genética
predisposição genética
title_short Genetics of diabetic nephropathy
title_full Genetics of diabetic nephropathy
title_fullStr Genetics of diabetic nephropathy
title_full_unstemmed Genetics of diabetic nephropathy
title_sort Genetics of diabetic nephropathy
author Carpena, Mariana P.
author_facet Carpena, Mariana P.
Rados, Dimitris V.
Sortica, Denise A.
Souza, Bianca M. De
Reis, André Fernandes [UNIFESP]
Canani, Luis Henrique
Crispim, Daisy
author_role author
author2 Rados, Dimitris V.
Sortica, Denise A.
Souza, Bianca M. De
Reis, André Fernandes [UNIFESP]
Canani, Luis Henrique
Crispim, Daisy
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Hospital de Clínicas de Porto Alegre Serviço de Endocrinologia
Universidade Federal do Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Carpena, Mariana P.
Rados, Dimitris V.
Sortica, Denise A.
Souza, Bianca M. De
Reis, André Fernandes [UNIFESP]
Canani, Luis Henrique
Crispim, Daisy
dc.subject.por.fl_str_mv Nephropathy
diabetes mellitus
genetics
genetic predisposition
Nefropatia
diabetes melito
genética
predisposição genética
topic Nephropathy
diabetes mellitus
genetics
genetic predisposition
Nefropatia
diabetes melito
genética
predisposição genética
description The increasing prevalence of diabetes mellitus has led to a growing number of chronic complications including diabetic nephropathy (DN). In addition to its high prevalence, DN is associated with high morbidity and mortality especially due to cardiovascular diseases. It is well established that genetic factors play a role in the pathogenesis of DN and genetically susceptible individuals can develop it after being exposed to environmental factors. DN is probably a complex, polygenic disease. Two main strategies have been used to identify genes associated to DN: analysis of candidate genes, and more recently genome-wide scan. Great efforts have been made to identify these main genes, but results are still inconsistent with different genes associated to a small effect in specific populations. The identification of the main genes would allow the detection of those individuals at high risk for DN and better understanding of its pathophysiology as well.
publishDate 2010
dc.date.none.fl_str_mv 2010-03-01
2015-06-14T13:41:33Z
2015-06-14T13:41:33Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27302010000300002
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 54, n. 3, p. 253-261, 2010.
10.1590/S0004-27302010000300002
S0004-27302010000300002.pdf
0004-2730
S0004-27302010000300002
http://repositorio.unifesp.br/handle/11600/5624
url http://dx.doi.org/10.1590/S0004-27302010000300002
http://repositorio.unifesp.br/handle/11600/5624
identifier_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 54, n. 3, p. 253-261, 2010.
10.1590/S0004-27302010000300002
S0004-27302010000300002.pdf
0004-2730
S0004-27302010000300002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 253-261
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268404698185728

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