Attenuation of motor deficits by hydroethanolic extract of Poincianella pyramidalis in a Parkinson's disease model

• Autor(a) principal: Lins, Lívia Cristina Rodrigues Ferreira
• Data de Publicação: 2017
• Outros Autores: Souza, Marina Freire de, Cintra, Rachel Rocha, Medeiros, Katty Anne Amador de Lucena, Macedo-Lima, Matheus, Moraes, Sabrina Zelice Cruz de, Estevam, Charles dos Santos, Almeida, Grace Kelly Melo de, Santos, Sandra Lauton, Ribeiro, Alessandra Mussi [UNIFESP], Silva, Regina Helena [UNIFESP], Santos, José Ronaldo dos, Marchioro, Murilo
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://blacpma.ms-editions.cl/index.php/blacpma/article/view/173; https://repositorio.unifesp.br/handle/11600/55089
• topic: Natural Products; Oxidative stress; Motor symptoms; Reserpine; Parkinson's disease; Productos Naturales; Estrés oxidativo; Síntomas motores; Reserpina; Enfermedad de Parkinson

The present study aimed to evaluate the possible neuroprotective effect of the hydroethanolic extract of Poincianella pyramidalis (EFIPp) (Tul.) L. P. Queiroz (Fabaceae), an endemic plant found in Northeastern Brazil, commonly used in folk medicine, on the motor deficits induced by repeated treatment with reserpine (RES) in rats. Adult male Wistar rats received 10 s.c. injections of 0.1 mg/kg RES or vehicle (VR), every 48 h, and daily i.p. injections daily of HEPp (25 mg/kg) or vehicle (VE). Throughout treatment, catalepsy behavior and oral movements were scored. After behavioral tests, superoxide dismutase (SOD) and catalase (CAT) activities were evaluated in the prefrontal cortex, hippocampus and striatum. RES treatment induced a progressive increase of catalepsy time in the treated group compared to control groups starting at day 15. RES also increased the number of vacuous chewing movements, tongue protrusions and duration of facial twitching. Treatment with HEPp attenuated the motor deficit in the catalepsy test and delayed the onset of oral movements induced by RES. No significant changes were observed in the antioxidant assay. Taken together, these results show a beneficial effect of HEPp on motor deficits induced by reserpine, suggesting a neuroprotective effect in a rat model of PD.