Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients

Detalhes bibliográficos
Autor(a) principal: Pereira, João Kleber Novais
Data de Publicação: 2012
Outros Autores: Traina, Fabíola, Machado-Neto, João Agostinho, Duarte, Adriana da Silva Santos, Saad, Sara Teresinha Olalla, Favaro, Patricia [UNIFESP], Lopes, Matheus Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.leukres.2012.06.010
http://repositorio.unifesp.br/handle/11600/35296
Resumo: Recent studies have indicated the Musashi2/NUMB pathway as the key regulator of differentiation in chronic myeloid leukemia; however, a comparison of both gene expressions has not yet been made in myelodysplastic syndrome (MDS) and in acute myeloid leukemia (AML). We herein, demonstrate a statistically significant down-modulation of NUMB expression level in high-risk MDS and AML, compared with control individuals. MSI2 expression was significantly reduced in low and high-risk MDS compared with normal control samples. NUMB expression was significantly lower than that of MSI2 in both MDS and AML patient samples, but no differences in the expression levels for either gene were observed in healthy bone marrow cells. Finally, NUMB expression was significantly up-regulated during differentiation of normal and low-risk MDS CD34(+) cells through the erythroid lineage. Taken together, results suggest the involvement of NUMB in MDS erythropoiesis; its down-modulation may have a role in MDS progression. (C) 2012 Elsevier B.V. All rights reserved.
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spelling Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patientsMusashi 2NUMBMyelodysplastic syndromesAcute myeloid leukemiaDifferentiationRecent studies have indicated the Musashi2/NUMB pathway as the key regulator of differentiation in chronic myeloid leukemia; however, a comparison of both gene expressions has not yet been made in myelodysplastic syndrome (MDS) and in acute myeloid leukemia (AML). We herein, demonstrate a statistically significant down-modulation of NUMB expression level in high-risk MDS and AML, compared with control individuals. MSI2 expression was significantly reduced in low and high-risk MDS compared with normal control samples. NUMB expression was significantly lower than that of MSI2 in both MDS and AML patient samples, but no differences in the expression levels for either gene were observed in healthy bone marrow cells. Finally, NUMB expression was significantly up-regulated during differentiation of normal and low-risk MDS CD34(+) cells through the erythroid lineage. Taken together, results suggest the involvement of NUMB in MDS erythropoiesis; its down-modulation may have a role in MDS progression. (C) 2012 Elsevier B.V. All rights reserved.Univ Estadual Campinas, UNICAMP, Hemoctr, Hematol & Hemotherapy Ctr,Inst Nacl Ciencia & Tec, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biol Sci, São Paulo, BrazilWeb of ScienceConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Elsevier B.V.Universidade Estadual de Campinas (UNICAMP)Universidade Federal de São Paulo (UNIFESP)Pereira, João Kleber NovaisTraina, FabíolaMachado-Neto, João AgostinhoDuarte, Adriana da Silva SantosSaad, Sara Teresinha OlallaFavaro, Patricia [UNIFESP]Lopes, Matheus Rodrigues2016-01-24T14:27:44Z2016-01-24T14:27:44Z2012-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1300-1303application/pdfhttp://dx.doi.org/10.1016/j.leukres.2012.06.010Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 36, n. 10, p. 1300-1303, 2012.10.1016/j.leukres.2012.06.010WOS000308044100017.pdf0145-2126http://repositorio.unifesp.br/handle/11600/35296WOS:000308044100017engLeukemia Researchinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T02:57:10Zoai:repositorio.unifesp.br/:11600/35296Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T02:57:10Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
title Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
spellingShingle Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
Pereira, João Kleber Novais
Musashi 2
NUMB
Myelodysplastic syndromes
Acute myeloid leukemia
Differentiation
title_short Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
title_full Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
title_fullStr Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
title_full_unstemmed Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
title_sort Distinct expression profiles of MSI2 and NUMB genes in myelodysplastic syndromes and acute myeloid leukemia patients
author Pereira, João Kleber Novais
author_facet Pereira, João Kleber Novais
Traina, Fabíola
Machado-Neto, João Agostinho
Duarte, Adriana da Silva Santos
Saad, Sara Teresinha Olalla
Favaro, Patricia [UNIFESP]
Lopes, Matheus Rodrigues
author_role author
author2 Traina, Fabíola
Machado-Neto, João Agostinho
Duarte, Adriana da Silva Santos
Saad, Sara Teresinha Olalla
Favaro, Patricia [UNIFESP]
Lopes, Matheus Rodrigues
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Pereira, João Kleber Novais
Traina, Fabíola
Machado-Neto, João Agostinho
Duarte, Adriana da Silva Santos
Saad, Sara Teresinha Olalla
Favaro, Patricia [UNIFESP]
Lopes, Matheus Rodrigues
dc.subject.por.fl_str_mv Musashi 2
NUMB
Myelodysplastic syndromes
Acute myeloid leukemia
Differentiation
topic Musashi 2
NUMB
Myelodysplastic syndromes
Acute myeloid leukemia
Differentiation
description Recent studies have indicated the Musashi2/NUMB pathway as the key regulator of differentiation in chronic myeloid leukemia; however, a comparison of both gene expressions has not yet been made in myelodysplastic syndrome (MDS) and in acute myeloid leukemia (AML). We herein, demonstrate a statistically significant down-modulation of NUMB expression level in high-risk MDS and AML, compared with control individuals. MSI2 expression was significantly reduced in low and high-risk MDS compared with normal control samples. NUMB expression was significantly lower than that of MSI2 in both MDS and AML patient samples, but no differences in the expression levels for either gene were observed in healthy bone marrow cells. Finally, NUMB expression was significantly up-regulated during differentiation of normal and low-risk MDS CD34(+) cells through the erythroid lineage. Taken together, results suggest the involvement of NUMB in MDS erythropoiesis; its down-modulation may have a role in MDS progression. (C) 2012 Elsevier B.V. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-10-01
2016-01-24T14:27:44Z
2016-01-24T14:27:44Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.leukres.2012.06.010
Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 36, n. 10, p. 1300-1303, 2012.
10.1016/j.leukres.2012.06.010
WOS000308044100017.pdf
0145-2126
http://repositorio.unifesp.br/handle/11600/35296
WOS:000308044100017
url http://dx.doi.org/10.1016/j.leukres.2012.06.010
http://repositorio.unifesp.br/handle/11600/35296
identifier_str_mv Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 36, n. 10, p. 1300-1303, 2012.
10.1016/j.leukres.2012.06.010
WOS000308044100017.pdf
0145-2126
WOS:000308044100017
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Leukemia Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 1300-1303
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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