Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54229 http://dx.doi.org/10.1111/aji.12776 |
Resumo: | Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro- and anti-inflammatory biomarkers reported in intra-uterine tissues (amnion, chorion, decidua, placenta, and myometrium) at term labor. We conducted a systematic review of studies on pro- and anti-inflammatory biomarkers (mRNA and/or protein) reported in feto-maternal tissues during normal human term labor, published in English (1980-2016), in 3 electronic data bases. From a total of 3712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL-6, IL-8, IL-1, COX-2, PGE-2, TNF-, and hCAP18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto-maternal compartments at term labor. Increase in pro-inflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Anti-inflammatory markers at term labor are hardly reported. |
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Hadley, Emily E.Richardson, Lauren S.Torloni, Maria R. [UNIFESP]Menon, Ramkumar2020-07-08T13:09:49Z2020-07-08T13:09:49Z2018American Journal Of Reproductive Immunology. Hoboken, v. 79, n. 2, p. -, 2018.1046-7408https://repositorio.unifesp.br/handle/11600/54229http://dx.doi.org/10.1111/aji.1277610.1111/aji.12776WOS:000423176200001Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro- and anti-inflammatory biomarkers reported in intra-uterine tissues (amnion, chorion, decidua, placenta, and myometrium) at term labor. We conducted a systematic review of studies on pro- and anti-inflammatory biomarkers (mRNA and/or protein) reported in feto-maternal tissues during normal human term labor, published in English (1980-2016), in 3 electronic data bases. From a total of 3712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL-6, IL-8, IL-1, COX-2, PGE-2, TNF-, and hCAP18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto-maternal compartments at term labor. Increase in pro-inflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Anti-inflammatory markers at term labor are hardly reported.NICHDUniv Texas Med Branch, Dept Obstet & Gynecol, Div Maternal Fetal Med & Perinatal Res, Galveston, TX 77555 USAUniv Fed Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Obstet & Gynecol, Sao Paulo, BrazilNICHD: 1R03HD086354-01Web of Science-engWileyAmerican Journal Of Reproductive Immunologydeciduafetal membranesinflammationmyometriumplacentasystematic reviewGestational tissue inflammatory biomarkers at term labor: Asystematic review of literatureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHoboken792info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/542292022-02-08 12:46:04.427metadata only accessoai:repositorio.unifesp.br:11600/54229Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-02-08T15:46:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature |
title |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature |
spellingShingle |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature Hadley, Emily E. decidua fetal membranes inflammation myometrium placenta systematic review |
title_short |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature |
title_full |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature |
title_fullStr |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature |
title_full_unstemmed |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature |
title_sort |
Gestational tissue inflammatory biomarkers at term labor: Asystematic review of literature |
author |
Hadley, Emily E. |
author_facet |
Hadley, Emily E. Richardson, Lauren S. Torloni, Maria R. [UNIFESP] Menon, Ramkumar |
author_role |
author |
author2 |
Richardson, Lauren S. Torloni, Maria R. [UNIFESP] Menon, Ramkumar |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Hadley, Emily E. Richardson, Lauren S. Torloni, Maria R. [UNIFESP] Menon, Ramkumar |
dc.subject.eng.fl_str_mv |
decidua fetal membranes inflammation myometrium placenta systematic review |
topic |
decidua fetal membranes inflammation myometrium placenta systematic review |
description |
Parturition at term is characterized by inflammatory overload in both feto-maternal tissues. Despite the large number of individual studies on changes in inflammatory biomarkers linked to labor, a comprehensive profile of them in each of the uterine compartments is not available to better understand their mechanistic contributions to labor. This systematic review investigated the pro- and anti-inflammatory biomarkers reported in intra-uterine tissues (amnion, chorion, decidua, placenta, and myometrium) at term labor. We conducted a systematic review of studies on pro- and anti-inflammatory biomarkers (mRNA and/or protein) reported in feto-maternal tissues during normal human term labor, published in English (1980-2016), in 3 electronic data bases. From a total of 3712 citations, 172 were included for final review. Each tissue expresses a unique set of biomarkers at the time of term labor, but there is significant overlap between tissues. All tissues had IL-6, IL-8, IL-1, COX-2, PGE-2, TNF-, and hCAP18 in common at term labor. Common and unique inflammatory biomarkers are expressed in various feto-maternal compartments at term labor. Increase in pro-inflammatory markers in all gestational tissue signifies their harmonious functional role in promoting labor. Anti-inflammatory markers at term labor are hardly reported. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-08T13:09:49Z |
dc.date.available.fl_str_mv |
2020-07-08T13:09:49Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal Of Reproductive Immunology. Hoboken, v. 79, n. 2, p. -, 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54229 http://dx.doi.org/10.1111/aji.12776 |
dc.identifier.issn.none.fl_str_mv |
1046-7408 |
dc.identifier.doi.none.fl_str_mv |
10.1111/aji.12776 |
dc.identifier.wos.none.fl_str_mv |
WOS:000423176200001 |
identifier_str_mv |
American Journal Of Reproductive Immunology. Hoboken, v. 79, n. 2, p. -, 2018. 1046-7408 10.1111/aji.12776 WOS:000423176200001 |
url |
https://repositorio.unifesp.br/handle/11600/54229 http://dx.doi.org/10.1111/aji.12776 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal Of Reproductive Immunology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- |
dc.coverage.none.fl_str_mv |
Hoboken |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764166997475328 |