Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica

Detalhes bibliográficos
Autor(a) principal: Makdisse, Marcia [UNIFESP]
Data de Publicação: 2007
Outros Autores: Ramos, Luiz Roberto [UNIFESP], Moreira, Frederico [UNIFESP], Oliveira, Anderson [UNIFESP], Berwanger, Otávio [UNIFESP], Moscardi, Alcione [UNIFESP], Junqueira, Virginia [UNIFESP], Rodrigues, Evandro [UNIFESP], Carvalho, Antonio Carlos [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000xh7g
DOI: 10.1590/S0066-782X2007000600002
Texto Completo: http://dx.doi.org/10.1590/S0066-782X2007000600002
http://repositorio.unifesp.br/handle/11600/3742
Resumo: BACKGROUND: The prevalence of peripheral arterial disease (PAD) in the elderly is high. Most are asymptomatic and the sensitivity of the physical exam is low. In Brazil, little is known in regard to PAD risk factors in the elderly. OBJECTIVES: To identify risk factors for PAD among elderly individuals (> 75 years) in the community and to develop a prediction score. METHODS: Cross-sectional, prospective, community-based study nested within a cohort study (Epidoso). A total of 176 individuals were assessed. PAD was defined as an ankle-brachial index <0.9. Risk factors associated with PAD were entered into a multivariate logistic regression model. Statistical modeling was used to formulate a score according to the likelihood of PAD. A p value <0.05 was significant. RESULTS: PAD was present in 36.4% of participants. Abnormal pedal pulses, hypertension, cigarette smoking, and complain of leg pain/discomfort in either leg on walking were predictors of PAD. Based on the coefficients of the logistic regression, these variables were given scores of 13, 9, 5 and 5, respectively. A cutoff point >18 points defined the high risk individuals and yielded sensitivity, specificity, positive predictive value and negative predictive value of 85.9%, 71.4%, 63.2% and 89.9%, respectively. Receiver-operator characteristic analysis yielded area under curve of 85%, indicating excellent discrimination and goodness-of-fit statistics indicated excellent calibration (p=0.639). CONCLUSION: Because of its good performance, the proposed score can become a simple and useful tool to identify elderly community residents at higher risk of PAD who should be considered for further investigation.
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spelling Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periféricaA risk score for predicting peripheral arterial disease in individuals 75 years or olderArterial occlusive diseasesriskagedArteriopatias oclusivasriscoidosoBACKGROUND: The prevalence of peripheral arterial disease (PAD) in the elderly is high. Most are asymptomatic and the sensitivity of the physical exam is low. In Brazil, little is known in regard to PAD risk factors in the elderly. OBJECTIVES: To identify risk factors for PAD among elderly individuals (> 75 years) in the community and to develop a prediction score. METHODS: Cross-sectional, prospective, community-based study nested within a cohort study (Epidoso). A total of 176 individuals were assessed. PAD was defined as an ankle-brachial index <0.9. Risk factors associated with PAD were entered into a multivariate logistic regression model. Statistical modeling was used to formulate a score according to the likelihood of PAD. A p value <0.05 was significant. RESULTS: PAD was present in 36.4% of participants. Abnormal pedal pulses, hypertension, cigarette smoking, and complain of leg pain/discomfort in either leg on walking were predictors of PAD. Based on the coefficients of the logistic regression, these variables were given scores of 13, 9, 5 and 5, respectively. A cutoff point >18 points defined the high risk individuals and yielded sensitivity, specificity, positive predictive value and negative predictive value of 85.9%, 71.4%, 63.2% and 89.9%, respectively. Receiver-operator characteristic analysis yielded area under curve of 85%, indicating excellent discrimination and goodness-of-fit statistics indicated excellent calibration (p=0.639). CONCLUSION: Because of its good performance, the proposed score can become a simple and useful tool to identify elderly community residents at higher risk of PAD who should be considered for further investigation.FUNDAMENTO: A prevalência de doença arterial periférica (DAP) é elevada entre os idosos. A maioria é assintomática e o exame físico pouco sensível. No Brasil, os fatores associados à DAP em idosos são pouco conhecidos. OBEJETIVOS: Identificar os fatores associados à presença de doença arterial periférica (DAP) em idosos (> 75 anos) da comunidade e desenvolver um escore de predição da doença. MÉTODOS: Estudo transversal, aninhado em uma coorte prospectiva (Epidoso). Foram avaliados 176 idosos (> 75 anos) da comunidade. A presença de DAP foi definida por meio do índice tornozelo-braquial <0,90. Os fatores associados à DAP, na análise univariada, foram analisados em modelo de regressão logística múltipla e um escore foi formulado de acordo com a probabilidade da doença. Valores de p<0,05 foram considerados significantes. RESULTADOS: A prevalência de DAP foi de 36,4%. Os preditores de DAP foram: anormalidades dos pulsos dos tornozelos, hipertensão arterial, tabagismo e dor/desconforto na(s) perna(s) durante a caminhada. Essas variáveis obtiveram escores de 13, 9, 5 e 5, respectivamente. O ponto de corte (cutoff) para definir alto risco de DAP ficou acima dos 18 pontos e resultou em sensibilidade de 85,9%, especificidade de 71,4%, valor preditivo (VP) positivo de 63,2% e VP negativo de 89,9%. O poder discriminatório e a calibração foram excelentes (área sob a curva ROC=85% e teste goodness-of-fit=p=0,639). CONCLUSÃO: Em razão do bom desempenho, o escore proposto pode tornar-se uma ferramenta simples e útil para identificar os idosos (> 75 anos) da comunidade com alto risco para DAP e que mereceriam investigação mais detalhada.Universidade Federal de São Paulo (UNIFESP)Hospital Israelita Albert EinsteinUNIFESPSciELOSociedade Brasileira de Cardiologia - SBCUniversidade Federal de São Paulo (UNIFESP)Hospital Israelita Albert EinsteinMakdisse, Marcia [UNIFESP]Ramos, Luiz Roberto [UNIFESP]Moreira, Frederico [UNIFESP]Oliveira, Anderson [UNIFESP]Berwanger, Otávio [UNIFESP]Moscardi, Alcione [UNIFESP]Junqueira, Virginia [UNIFESP]Rodrigues, Evandro [UNIFESP]Carvalho, Antonio Carlos [UNIFESP]2015-06-14T13:36:56Z2015-06-14T13:36:56Z2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion630-636application/pdfhttp://dx.doi.org/10.1590/S0066-782X2007000600002Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 88, n. 6, p. 630-636, 2007.10.1590/S0066-782X2007000600002S0066-782X2007000600002.pdf0066-782XS0066-782X2007000600002http://repositorio.unifesp.br/handle/11600/3742ark:/48912/001300000xh7gporArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T20:37:38Zoai:repositorio.unifesp.br/:11600/3742Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:43:23.722547Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
A risk score for predicting peripheral arterial disease in individuals 75 years or older
title Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
spellingShingle Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
Makdisse, Marcia [UNIFESP]
Arterial occlusive diseases
risk
aged
Arteriopatias oclusivas
risco
idoso
Makdisse, Marcia [UNIFESP]
Arterial occlusive diseases
risk
aged
Arteriopatias oclusivas
risco
idoso
title_short Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
title_full Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
title_fullStr Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
title_full_unstemmed Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
title_sort Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
author Makdisse, Marcia [UNIFESP]
author_facet Makdisse, Marcia [UNIFESP]
Makdisse, Marcia [UNIFESP]
Ramos, Luiz Roberto [UNIFESP]
Moreira, Frederico [UNIFESP]
Oliveira, Anderson [UNIFESP]
Berwanger, Otávio [UNIFESP]
Moscardi, Alcione [UNIFESP]
Junqueira, Virginia [UNIFESP]
Rodrigues, Evandro [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
Ramos, Luiz Roberto [UNIFESP]
Moreira, Frederico [UNIFESP]
Oliveira, Anderson [UNIFESP]
Berwanger, Otávio [UNIFESP]
Moscardi, Alcione [UNIFESP]
Junqueira, Virginia [UNIFESP]
Rodrigues, Evandro [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
author_role author
author2 Ramos, Luiz Roberto [UNIFESP]
Moreira, Frederico [UNIFESP]
Oliveira, Anderson [UNIFESP]
Berwanger, Otávio [UNIFESP]
Moscardi, Alcione [UNIFESP]
Junqueira, Virginia [UNIFESP]
Rodrigues, Evandro [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Hospital Israelita Albert Einstein
dc.contributor.author.fl_str_mv Makdisse, Marcia [UNIFESP]
Ramos, Luiz Roberto [UNIFESP]
Moreira, Frederico [UNIFESP]
Oliveira, Anderson [UNIFESP]
Berwanger, Otávio [UNIFESP]
Moscardi, Alcione [UNIFESP]
Junqueira, Virginia [UNIFESP]
Rodrigues, Evandro [UNIFESP]
Carvalho, Antonio Carlos [UNIFESP]
dc.subject.por.fl_str_mv Arterial occlusive diseases
risk
aged
Arteriopatias oclusivas
risco
idoso
topic Arterial occlusive diseases
risk
aged
Arteriopatias oclusivas
risco
idoso
description BACKGROUND: The prevalence of peripheral arterial disease (PAD) in the elderly is high. Most are asymptomatic and the sensitivity of the physical exam is low. In Brazil, little is known in regard to PAD risk factors in the elderly. OBJECTIVES: To identify risk factors for PAD among elderly individuals (> 75 years) in the community and to develop a prediction score. METHODS: Cross-sectional, prospective, community-based study nested within a cohort study (Epidoso). A total of 176 individuals were assessed. PAD was defined as an ankle-brachial index <0.9. Risk factors associated with PAD were entered into a multivariate logistic regression model. Statistical modeling was used to formulate a score according to the likelihood of PAD. A p value <0.05 was significant. RESULTS: PAD was present in 36.4% of participants. Abnormal pedal pulses, hypertension, cigarette smoking, and complain of leg pain/discomfort in either leg on walking were predictors of PAD. Based on the coefficients of the logistic regression, these variables were given scores of 13, 9, 5 and 5, respectively. A cutoff point >18 points defined the high risk individuals and yielded sensitivity, specificity, positive predictive value and negative predictive value of 85.9%, 71.4%, 63.2% and 89.9%, respectively. Receiver-operator characteristic analysis yielded area under curve of 85%, indicating excellent discrimination and goodness-of-fit statistics indicated excellent calibration (p=0.639). CONCLUSION: Because of its good performance, the proposed score can become a simple and useful tool to identify elderly community residents at higher risk of PAD who should be considered for further investigation.
publishDate 2007
dc.date.none.fl_str_mv 2007-06-01
2015-06-14T13:36:56Z
2015-06-14T13:36:56Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0066-782X2007000600002
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 88, n. 6, p. 630-636, 2007.
10.1590/S0066-782X2007000600002
S0066-782X2007000600002.pdf
0066-782X
S0066-782X2007000600002
http://repositorio.unifesp.br/handle/11600/3742
dc.identifier.dark.fl_str_mv ark:/48912/001300000xh7g
url http://dx.doi.org/10.1590/S0066-782X2007000600002
http://repositorio.unifesp.br/handle/11600/3742
identifier_str_mv Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 88, n. 6, p. 630-636, 2007.
10.1590/S0066-782X2007000600002
S0066-782X2007000600002.pdf
0066-782X
S0066-782X2007000600002
ark:/48912/001300000xh7g
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Arquivos Brasileiros de Cardiologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 630-636
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
publisher.none.fl_str_mv Sociedade Brasileira de Cardiologia - SBC
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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dc.identifier.doi.none.fl_str_mv 10.1590/S0066-782X2007000600002