Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/001300000xh7g |
DOI: | 10.1590/S0066-782X2007000600002 |
Texto Completo: | http://dx.doi.org/10.1590/S0066-782X2007000600002 http://repositorio.unifesp.br/handle/11600/3742 |
Resumo: | BACKGROUND: The prevalence of peripheral arterial disease (PAD) in the elderly is high. Most are asymptomatic and the sensitivity of the physical exam is low. In Brazil, little is known in regard to PAD risk factors in the elderly. OBJECTIVES: To identify risk factors for PAD among elderly individuals (> 75 years) in the community and to develop a prediction score. METHODS: Cross-sectional, prospective, community-based study nested within a cohort study (Epidoso). A total of 176 individuals were assessed. PAD was defined as an ankle-brachial index <0.9. Risk factors associated with PAD were entered into a multivariate logistic regression model. Statistical modeling was used to formulate a score according to the likelihood of PAD. A p value <0.05 was significant. RESULTS: PAD was present in 36.4% of participants. Abnormal pedal pulses, hypertension, cigarette smoking, and complain of leg pain/discomfort in either leg on walking were predictors of PAD. Based on the coefficients of the logistic regression, these variables were given scores of 13, 9, 5 and 5, respectively. A cutoff point >18 points defined the high risk individuals and yielded sensitivity, specificity, positive predictive value and negative predictive value of 85.9%, 71.4%, 63.2% and 89.9%, respectively. Receiver-operator characteristic analysis yielded area under curve of 85%, indicating excellent discrimination and goodness-of-fit statistics indicated excellent calibration (p=0.639). CONCLUSION: Because of its good performance, the proposed score can become a simple and useful tool to identify elderly community residents at higher risk of PAD who should be considered for further investigation. |
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Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periféricaA risk score for predicting peripheral arterial disease in individuals 75 years or olderArterial occlusive diseasesriskagedArteriopatias oclusivasriscoidosoBACKGROUND: The prevalence of peripheral arterial disease (PAD) in the elderly is high. Most are asymptomatic and the sensitivity of the physical exam is low. In Brazil, little is known in regard to PAD risk factors in the elderly. OBJECTIVES: To identify risk factors for PAD among elderly individuals (> 75 years) in the community and to develop a prediction score. METHODS: Cross-sectional, prospective, community-based study nested within a cohort study (Epidoso). A total of 176 individuals were assessed. PAD was defined as an ankle-brachial index <0.9. Risk factors associated with PAD were entered into a multivariate logistic regression model. Statistical modeling was used to formulate a score according to the likelihood of PAD. A p value <0.05 was significant. RESULTS: PAD was present in 36.4% of participants. Abnormal pedal pulses, hypertension, cigarette smoking, and complain of leg pain/discomfort in either leg on walking were predictors of PAD. Based on the coefficients of the logistic regression, these variables were given scores of 13, 9, 5 and 5, respectively. A cutoff point >18 points defined the high risk individuals and yielded sensitivity, specificity, positive predictive value and negative predictive value of 85.9%, 71.4%, 63.2% and 89.9%, respectively. Receiver-operator characteristic analysis yielded area under curve of 85%, indicating excellent discrimination and goodness-of-fit statistics indicated excellent calibration (p=0.639). CONCLUSION: Because of its good performance, the proposed score can become a simple and useful tool to identify elderly community residents at higher risk of PAD who should be considered for further investigation.FUNDAMENTO: A prevalência de doença arterial periférica (DAP) é elevada entre os idosos. A maioria é assintomática e o exame físico pouco sensível. No Brasil, os fatores associados à DAP em idosos são pouco conhecidos. OBEJETIVOS: Identificar os fatores associados à presença de doença arterial periférica (DAP) em idosos (> 75 anos) da comunidade e desenvolver um escore de predição da doença. MÉTODOS: Estudo transversal, aninhado em uma coorte prospectiva (Epidoso). Foram avaliados 176 idosos (> 75 anos) da comunidade. A presença de DAP foi definida por meio do índice tornozelo-braquial <0,90. Os fatores associados à DAP, na análise univariada, foram analisados em modelo de regressão logística múltipla e um escore foi formulado de acordo com a probabilidade da doença. Valores de p<0,05 foram considerados significantes. RESULTADOS: A prevalência de DAP foi de 36,4%. Os preditores de DAP foram: anormalidades dos pulsos dos tornozelos, hipertensão arterial, tabagismo e dor/desconforto na(s) perna(s) durante a caminhada. Essas variáveis obtiveram escores de 13, 9, 5 e 5, respectivamente. O ponto de corte (cutoff) para definir alto risco de DAP ficou acima dos 18 pontos e resultou em sensibilidade de 85,9%, especificidade de 71,4%, valor preditivo (VP) positivo de 63,2% e VP negativo de 89,9%. O poder discriminatório e a calibração foram excelentes (área sob a curva ROC=85% e teste goodness-of-fit=p=0,639). CONCLUSÃO: Em razão do bom desempenho, o escore proposto pode tornar-se uma ferramenta simples e útil para identificar os idosos (> 75 anos) da comunidade com alto risco para DAP e que mereceriam investigação mais detalhada.Universidade Federal de São Paulo (UNIFESP)Hospital Israelita Albert EinsteinUNIFESPSciELOSociedade Brasileira de Cardiologia - SBCUniversidade Federal de São Paulo (UNIFESP)Hospital Israelita Albert EinsteinMakdisse, Marcia [UNIFESP]Ramos, Luiz Roberto [UNIFESP]Moreira, Frederico [UNIFESP]Oliveira, Anderson [UNIFESP]Berwanger, Otávio [UNIFESP]Moscardi, Alcione [UNIFESP]Junqueira, Virginia [UNIFESP]Rodrigues, Evandro [UNIFESP]Carvalho, Antonio Carlos [UNIFESP]2015-06-14T13:36:56Z2015-06-14T13:36:56Z2007-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion630-636application/pdfhttp://dx.doi.org/10.1590/S0066-782X2007000600002Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 88, n. 6, p. 630-636, 2007.10.1590/S0066-782X2007000600002S0066-782X2007000600002.pdf0066-782XS0066-782X2007000600002http://repositorio.unifesp.br/handle/11600/3742ark:/48912/001300000xh7gporArquivos Brasileiros de Cardiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T20:37:38Zoai:repositorio.unifesp.br/:11600/3742Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:43:23.722547Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica A risk score for predicting peripheral arterial disease in individuals 75 years or older |
title |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica |
spellingShingle |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica Makdisse, Marcia [UNIFESP] Arterial occlusive diseases risk aged Arteriopatias oclusivas risco idoso Makdisse, Marcia [UNIFESP] Arterial occlusive diseases risk aged Arteriopatias oclusivas risco idoso |
title_short |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica |
title_full |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica |
title_fullStr |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica |
title_full_unstemmed |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica |
title_sort |
Escore para rastrear idosos (> 75 anos) de alto risco para doença arterial periférica |
author |
Makdisse, Marcia [UNIFESP] |
author_facet |
Makdisse, Marcia [UNIFESP] Makdisse, Marcia [UNIFESP] Ramos, Luiz Roberto [UNIFESP] Moreira, Frederico [UNIFESP] Oliveira, Anderson [UNIFESP] Berwanger, Otávio [UNIFESP] Moscardi, Alcione [UNIFESP] Junqueira, Virginia [UNIFESP] Rodrigues, Evandro [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] Ramos, Luiz Roberto [UNIFESP] Moreira, Frederico [UNIFESP] Oliveira, Anderson [UNIFESP] Berwanger, Otávio [UNIFESP] Moscardi, Alcione [UNIFESP] Junqueira, Virginia [UNIFESP] Rodrigues, Evandro [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] |
author_role |
author |
author2 |
Ramos, Luiz Roberto [UNIFESP] Moreira, Frederico [UNIFESP] Oliveira, Anderson [UNIFESP] Berwanger, Otávio [UNIFESP] Moscardi, Alcione [UNIFESP] Junqueira, Virginia [UNIFESP] Rodrigues, Evandro [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Hospital Israelita Albert Einstein |
dc.contributor.author.fl_str_mv |
Makdisse, Marcia [UNIFESP] Ramos, Luiz Roberto [UNIFESP] Moreira, Frederico [UNIFESP] Oliveira, Anderson [UNIFESP] Berwanger, Otávio [UNIFESP] Moscardi, Alcione [UNIFESP] Junqueira, Virginia [UNIFESP] Rodrigues, Evandro [UNIFESP] Carvalho, Antonio Carlos [UNIFESP] |
dc.subject.por.fl_str_mv |
Arterial occlusive diseases risk aged Arteriopatias oclusivas risco idoso |
topic |
Arterial occlusive diseases risk aged Arteriopatias oclusivas risco idoso |
description |
BACKGROUND: The prevalence of peripheral arterial disease (PAD) in the elderly is high. Most are asymptomatic and the sensitivity of the physical exam is low. In Brazil, little is known in regard to PAD risk factors in the elderly. OBJECTIVES: To identify risk factors for PAD among elderly individuals (> 75 years) in the community and to develop a prediction score. METHODS: Cross-sectional, prospective, community-based study nested within a cohort study (Epidoso). A total of 176 individuals were assessed. PAD was defined as an ankle-brachial index <0.9. Risk factors associated with PAD were entered into a multivariate logistic regression model. Statistical modeling was used to formulate a score according to the likelihood of PAD. A p value <0.05 was significant. RESULTS: PAD was present in 36.4% of participants. Abnormal pedal pulses, hypertension, cigarette smoking, and complain of leg pain/discomfort in either leg on walking were predictors of PAD. Based on the coefficients of the logistic regression, these variables were given scores of 13, 9, 5 and 5, respectively. A cutoff point >18 points defined the high risk individuals and yielded sensitivity, specificity, positive predictive value and negative predictive value of 85.9%, 71.4%, 63.2% and 89.9%, respectively. Receiver-operator characteristic analysis yielded area under curve of 85%, indicating excellent discrimination and goodness-of-fit statistics indicated excellent calibration (p=0.639). CONCLUSION: Because of its good performance, the proposed score can become a simple and useful tool to identify elderly community residents at higher risk of PAD who should be considered for further investigation. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-06-01 2015-06-14T13:36:56Z 2015-06-14T13:36:56Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0066-782X2007000600002 Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 88, n. 6, p. 630-636, 2007. 10.1590/S0066-782X2007000600002 S0066-782X2007000600002.pdf 0066-782X S0066-782X2007000600002 http://repositorio.unifesp.br/handle/11600/3742 |
dc.identifier.dark.fl_str_mv |
ark:/48912/001300000xh7g |
url |
http://dx.doi.org/10.1590/S0066-782X2007000600002 http://repositorio.unifesp.br/handle/11600/3742 |
identifier_str_mv |
Arquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 88, n. 6, p. 630-636, 2007. 10.1590/S0066-782X2007000600002 S0066-782X2007000600002.pdf 0066-782X S0066-782X2007000600002 ark:/48912/001300000xh7g |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros de Cardiologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
630-636 application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
publisher.none.fl_str_mv |
Sociedade Brasileira de Cardiologia - SBC |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1822250687988236288 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0066-782X2007000600002 |