Localization of EP24.15, a major liver kininase

Detalhes bibliográficos
Autor(a) principal: Gioli-Pereira, Luciana [UNIFESP]
Data de Publicação: 2003
Outros Autores: Fontenele-Neto, José D., Borges, Durval R. [UNIFESP], Kouyoumdjian, Maria [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/11600/44385
http://dx.doi.org/10.1177/002215540305100115
Resumo: The liver is important for the kallikrein-kinin system modulation. This system plays a role in the inflammatory cascade with anticoagulant, profibrinolytic, and anti-adhesive attributes. The metalloendopeptidase EP24.15 is a major hepatic kininase. We studied the tissue distribution and subcellular localization of this enzyme in rat liver by cell fractionation and immunohistochemistry. Our results showed that EP24.15 is predominant in the soluble fraction of the liver homogenate and is present in the cytoplasm of hepatocytes, particularly in the perivenous zone (Z3). This localization is relevant because most hepatotoxin-induced necrosis, as well as ischemic hepatocellular injury, is predominant in Z3.
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spelling Gioli-Pereira, Luciana [UNIFESP]Fontenele-Neto, José D.Borges, Durval R. [UNIFESP]Kouyoumdjian, Maria [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)2018-06-15T18:02:18Z2018-06-15T18:02:18Z2003-01-01Journal Of Histochemistry & Cytochemistry. Seattle: Histochemical Soc Inc, v. 51, n. 1, p. 125-127, 2003.0022-1554http://repositorio.unifesp.br/11600/44385http://dx.doi.org/10.1177/00221554030510011510.1177/002215540305100115WOS:000180491300015The liver is important for the kallikrein-kinin system modulation. This system plays a role in the inflammatory cascade with anticoagulant, profibrinolytic, and anti-adhesive attributes. The metalloendopeptidase EP24.15 is a major hepatic kininase. We studied the tissue distribution and subcellular localization of this enzyme in rat liver by cell fractionation and immunohistochemistry. Our results showed that EP24.15 is predominant in the soluble fraction of the liver homogenate and is present in the cytoplasm of hepatocytes, particularly in the perivenous zone (Z3). This localization is relevant because most hepatotoxin-induced necrosis, as well as ischemic hepatocellular injury, is predominant in Z3.Univ Fed Sao Paulo, Lab Expt Hepatol, Sao Paulo, BrazilUSP, Inst Biomed Sci, Dept Histol & Embryol, BR-09500900 Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Expt Hepatol, Sao Paulo, BrazilWeb of Science125-127engHistochemical Soc IncJournal Of Histochemistry & Cytochemistrybradykininkininaseendopeptidase-24.15liverLocalization of EP24.15, a major liver kininaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/443852021-10-05 21:59:10.169metadata only accessoai:repositorio.unifesp.br:11600/44385Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:59:10Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Localization of EP24.15, a major liver kininase
title Localization of EP24.15, a major liver kininase
spellingShingle Localization of EP24.15, a major liver kininase
Gioli-Pereira, Luciana [UNIFESP]
bradykinin
kininase
endopeptidase-24.15
liver
title_short Localization of EP24.15, a major liver kininase
title_full Localization of EP24.15, a major liver kininase
title_fullStr Localization of EP24.15, a major liver kininase
title_full_unstemmed Localization of EP24.15, a major liver kininase
title_sort Localization of EP24.15, a major liver kininase
author Gioli-Pereira, Luciana [UNIFESP]
author_facet Gioli-Pereira, Luciana [UNIFESP]
Fontenele-Neto, José D.
Borges, Durval R. [UNIFESP]
Kouyoumdjian, Maria [UNIFESP]
author_role author
author2 Fontenele-Neto, José D.
Borges, Durval R. [UNIFESP]
Kouyoumdjian, Maria [UNIFESP]
author2_role author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
dc.contributor.author.fl_str_mv Gioli-Pereira, Luciana [UNIFESP]
Fontenele-Neto, José D.
Borges, Durval R. [UNIFESP]
Kouyoumdjian, Maria [UNIFESP]
dc.subject.eng.fl_str_mv bradykinin
kininase
endopeptidase-24.15
liver
topic bradykinin
kininase
endopeptidase-24.15
liver
description The liver is important for the kallikrein-kinin system modulation. This system plays a role in the inflammatory cascade with anticoagulant, profibrinolytic, and anti-adhesive attributes. The metalloendopeptidase EP24.15 is a major hepatic kininase. We studied the tissue distribution and subcellular localization of this enzyme in rat liver by cell fractionation and immunohistochemistry. Our results showed that EP24.15 is predominant in the soluble fraction of the liver homogenate and is present in the cytoplasm of hepatocytes, particularly in the perivenous zone (Z3). This localization is relevant because most hepatotoxin-induced necrosis, as well as ischemic hepatocellular injury, is predominant in Z3.
publishDate 2003
dc.date.issued.fl_str_mv 2003-01-01
dc.date.accessioned.fl_str_mv 2018-06-15T18:02:18Z
dc.date.available.fl_str_mv 2018-06-15T18:02:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Journal Of Histochemistry & Cytochemistry. Seattle: Histochemical Soc Inc, v. 51, n. 1, p. 125-127, 2003.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/11600/44385
http://dx.doi.org/10.1177/002215540305100115
dc.identifier.issn.none.fl_str_mv 0022-1554
dc.identifier.doi.none.fl_str_mv 10.1177/002215540305100115
dc.identifier.wos.none.fl_str_mv WOS:000180491300015
identifier_str_mv Journal Of Histochemistry & Cytochemistry. Seattle: Histochemical Soc Inc, v. 51, n. 1, p. 125-127, 2003.
0022-1554
10.1177/002215540305100115
WOS:000180491300015
url http://repositorio.unifesp.br/11600/44385
http://dx.doi.org/10.1177/002215540305100115
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Journal Of Histochemistry & Cytochemistry
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 125-127
dc.publisher.none.fl_str_mv Histochemical Soc Inc
publisher.none.fl_str_mv Histochemical Soc Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1802764130904440832

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