Estudos visando sínteses totais de substâncias bioativas
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/11600/67235 |
Resumo: | A química de benzino tem encontrado aplicações em química orgânica, incluindo sínteses totais de produtos naturais e preparações de materiais funcionais. Neste sentido, 2-(trimetilsilil)aril trifluorometanossulfonatos surgem como uma alternativa importante para a formação de benzino e derivados, sob condições reacionais brandas, ampliando o escopo de aplicações da química de benzino em química orgânica preparativa. Dentro deste contexto, realizamos estudos visando as sínteses totais de substâncias bioativas, a saber: cloridrato de (±)-apomorfina (protótipo aporfinoide); (S)-nuciferina e (R)- nuciferina (alcaloides aporfínicos), bem como morindaparvina A, 1,2- dimetoxiantraquinona, 1-metoxiantraquinona, 2,3-dimetilantraquinona e 2,3- difluorantraquinona (antraquinonas não quirais), com potenciais farmacológicos de interesse, empregando 2-(trimetilsilil)aril triflatos nas correspondentes etapas chaves, sob condições reacionais brandas. |
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Repositório Institucional da UNIFESP |
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Perecim, Givago Prado [UNIFESP]https://lattes.cnpq.br/5016162413844100http://lattes.cnpq.br/3153931165773039Raminelli, Cristiano [UNIFESP]Diadema2023-03-14T15:13:32Z2023-03-14T15:13:32Z2020-03-06https://repositorio.unifesp.br/11600/67235A química de benzino tem encontrado aplicações em química orgânica, incluindo sínteses totais de produtos naturais e preparações de materiais funcionais. Neste sentido, 2-(trimetilsilil)aril trifluorometanossulfonatos surgem como uma alternativa importante para a formação de benzino e derivados, sob condições reacionais brandas, ampliando o escopo de aplicações da química de benzino em química orgânica preparativa. Dentro deste contexto, realizamos estudos visando as sínteses totais de substâncias bioativas, a saber: cloridrato de (±)-apomorfina (protótipo aporfinoide); (S)-nuciferina e (R)- nuciferina (alcaloides aporfínicos), bem como morindaparvina A, 1,2- dimetoxiantraquinona, 1-metoxiantraquinona, 2,3-dimetilantraquinona e 2,3- difluorantraquinona (antraquinonas não quirais), com potenciais farmacológicos de interesse, empregando 2-(trimetilsilil)aril triflatos nas correspondentes etapas chaves, sob condições reacionais brandas.Benzene chemistry has found applications in organic chemistry, including total natural product syntheses and functional material preparations. In this sense, 2-(trimethylsilyl)aryl trifluoromethanesulfonates emerge as an important alternative for the formation of benzene and derivatives, under mild reaction conditions, expanding the scope of applications of benzene chemistry in preparative organic chemistry. Within this context, we carried out studies aiming at the total synthesis of bioactive substances, namely: (±)-apomorphine hydrochloride (aporphinoid prototype); (S)-nuciferin and (R)-nuciferin (aporphine alkaloids), as well as morindaparvin A, 1,2-dimethoxyanthraquinone, 1-methoxyanthraquinone, 2,3-dimethylanthraquinone and 2,3-difluoroanthraquinone (non-chiral anthraquinones), with potential pharmacological studies of interest, employing 2-(trimethylsilyl)aryl triflates in the corresponding key steps, under mild reaction conditions.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)221 f.porUniversidade Federal de São PauloQuímica de benzinoSínteses totaisSubstâncias bioativasAlcaloidesAntraquinonasBenzyne chemistryTotal synthesesBioactive substancesAlkaloidsAnthraquinonesEstudos visando sínteses totais de substâncias bioativasStudies aimed at total syntheses of substances 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InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-10-30T04:01:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.pt_BR.fl_str_mv |
Estudos visando sínteses totais de substâncias bioativas |
dc.title.alternative.pt_BR.fl_str_mv |
Studies aimed at total syntheses of substances bioactive |
title |
Estudos visando sínteses totais de substâncias bioativas |
spellingShingle |
Estudos visando sínteses totais de substâncias bioativas Perecim, Givago Prado [UNIFESP] Química de benzino Sínteses totais Substâncias bioativas Alcaloides Antraquinonas Benzyne chemistry Total syntheses Bioactive substances Alkaloids Anthraquinones |
title_short |
Estudos visando sínteses totais de substâncias bioativas |
title_full |
Estudos visando sínteses totais de substâncias bioativas |
title_fullStr |
Estudos visando sínteses totais de substâncias bioativas |
title_full_unstemmed |
Estudos visando sínteses totais de substâncias bioativas |
title_sort |
Estudos visando sínteses totais de substâncias bioativas |
author |
Perecim, Givago Prado [UNIFESP] |
author_facet |
Perecim, Givago Prado [UNIFESP] |
author_role |
author |
dc.contributor.authorLattes.pt_BR.fl_str_mv |
https://lattes.cnpq.br/5016162413844100 |
dc.contributor.advisorLattes.pt_BR.fl_str_mv |
http://lattes.cnpq.br/3153931165773039 |
dc.contributor.author.fl_str_mv |
Perecim, Givago Prado [UNIFESP] |
dc.contributor.advisor1.fl_str_mv |
Raminelli, Cristiano [UNIFESP] |
contributor_str_mv |
Raminelli, Cristiano [UNIFESP] |
dc.subject.por.fl_str_mv |
Química de benzino Sínteses totais Substâncias bioativas Alcaloides Antraquinonas |
topic |
Química de benzino Sínteses totais Substâncias bioativas Alcaloides Antraquinonas Benzyne chemistry Total syntheses Bioactive substances Alkaloids Anthraquinones |
dc.subject.eng.fl_str_mv |
Benzyne chemistry Total syntheses Bioactive substances Alkaloids Anthraquinones |
description |
A química de benzino tem encontrado aplicações em química orgânica, incluindo sínteses totais de produtos naturais e preparações de materiais funcionais. Neste sentido, 2-(trimetilsilil)aril trifluorometanossulfonatos surgem como uma alternativa importante para a formação de benzino e derivados, sob condições reacionais brandas, ampliando o escopo de aplicações da química de benzino em química orgânica preparativa. Dentro deste contexto, realizamos estudos visando as sínteses totais de substâncias bioativas, a saber: cloridrato de (±)-apomorfina (protótipo aporfinoide); (S)-nuciferina e (R)- nuciferina (alcaloides aporfínicos), bem como morindaparvina A, 1,2- dimetoxiantraquinona, 1-metoxiantraquinona, 2,3-dimetilantraquinona e 2,3- difluorantraquinona (antraquinonas não quirais), com potenciais farmacológicos de interesse, empregando 2-(trimetilsilil)aril triflatos nas correspondentes etapas chaves, sob condições reacionais brandas. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-03-06 |
dc.date.accessioned.fl_str_mv |
2023-03-14T15:13:32Z |
dc.date.available.fl_str_mv |
2023-03-14T15:13:32Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/11600/67235 |
url |
https://repositorio.unifesp.br/11600/67235 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
221 f. |
dc.coverage.spatial.pt_BR.fl_str_mv |
Diadema |
dc.publisher.none.fl_str_mv |
Universidade Federal de São Paulo |
publisher.none.fl_str_mv |
Universidade Federal de São Paulo |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
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MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764259105439744 |