Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population

Detalhes bibliográficos
Autor(a) principal: Smith, Marilia de Arruda Cardoso [UNIFESP]
Data de Publicação: 2005
Outros Autores: Silva, M.d.a. [UNIFESP], Araujo, Lara Miguel Quirino [UNIFESP], Ramos, Luiz Roberto [UNIFESP], Lábio, Roger Willian de, Burbano, Rommel Rodríguez [UNIFESP], Peres, Clovis de Araujo [UNIFESP], Andreoli, Sergio Baxter [UNIFESP], Payão, Spencer Luiz Marques [UNIFESP], Cendoroglo, Maysa Seabra [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-879X2005000700008
http://repositorio.unifesp.br/handle/11600/2592
Resumo: Werner syndrome (WS) is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for cardiovascular diseases. The identification of genetic polymorphisms as risk factors for complex diseases affecting older people can improve their prevention, diagnosis and prognosis. We investigated WRN codon 1367 polymorphism in 383 residents in a district of the city of São Paulo, who were enrolled in an Elderly Brazilian Longitudinal Study. Their mean age was 79.70 ± 5.32 years, ranging from 67 to 97. This population was composed of 262 females (68.4%) and 121 males (31.6%) of European (89.2%), Japanese (3.3%), Middle Eastern (1.81%), and mixed and/or other origins (5.7%). There are no studies concerning this polymorphism in Brazilian population. These subjects were evaluated clinically every two years. The major health problems and morbidities affecting this cohort were cardiovascular diseases (21.7%), hypertension (83.7%), diabetes (63.3%), obesity (41.23%), dementia (8.0%), depression (20.0%), and neoplasia (10.8%). Their prevalence is similar to some urban elderly Brazilian samples. DNA was isolated from blood cells, amplified by PCR and digested with PmaCI. Allele frequencies were 0.788 for the cysteine and 0.211 for the arginine. Genotype distributions were within that expected for the Hardy-Weinberg equilibrium. Female gender was associated with hypertension and obesity. Logistic regression analysis did not detect significant association between the polymorphism and morbidity. These findings confirm those from Europeans and differ from Japanese population.
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spelling Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian populationWRN: codon 1367 polymorphismAge-related morbiditiesElderly cohort studyWerner syndrome (WS) is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for cardiovascular diseases. The identification of genetic polymorphisms as risk factors for complex diseases affecting older people can improve their prevention, diagnosis and prognosis. We investigated WRN codon 1367 polymorphism in 383 residents in a district of the city of São Paulo, who were enrolled in an Elderly Brazilian Longitudinal Study. Their mean age was 79.70 ± 5.32 years, ranging from 67 to 97. This population was composed of 262 females (68.4%) and 121 males (31.6%) of European (89.2%), Japanese (3.3%), Middle Eastern (1.81%), and mixed and/or other origins (5.7%). There are no studies concerning this polymorphism in Brazilian population. These subjects were evaluated clinically every two years. The major health problems and morbidities affecting this cohort were cardiovascular diseases (21.7%), hypertension (83.7%), diabetes (63.3%), obesity (41.23%), dementia (8.0%), depression (20.0%), and neoplasia (10.8%). Their prevalence is similar to some urban elderly Brazilian samples. DNA was isolated from blood cells, amplified by PCR and digested with PmaCI. Allele frequencies were 0.788 for the cysteine and 0.211 for the arginine. Genotype distributions were within that expected for the Hardy-Weinberg equilibrium. Female gender was associated with hypertension and obesity. Logistic regression analysis did not detect significant association between the polymorphism and morbidity. These findings confirm those from Europeans and differ from Japanese population.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de MorfologiaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Clínica MédicaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Medicina PreventivaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de PsiquiatriaFaculdade de Medicina de Marília Hemocentro Disciplina de Genética e Biologia MolecularUNIFESP, EPM, Depto. de MorfologiaUNIFESP, EPM, Depto. de Clínica MédicaUNIFESP, EPM, Depto. de Medicina PreventivaUNIFESP, EPM, Depto. de PsiquiatriaSciELOAssociação Brasileira de Divulgação CientíficaUniversidade Federal de São Paulo (UNIFESP)Faculdade de Medicina de Marília Hemocentro Disciplina de Genética e Biologia MolecularSmith, Marilia de Arruda Cardoso [UNIFESP]Silva, M.d.a. [UNIFESP]Araujo, Lara Miguel Quirino [UNIFESP]Ramos, Luiz Roberto [UNIFESP]Lábio, Roger Willian deBurbano, Rommel Rodríguez [UNIFESP]Peres, Clovis de Araujo [UNIFESP]Andreoli, Sergio Baxter [UNIFESP]Payão, Spencer Luiz Marques [UNIFESP]Cendoroglo, Maysa Seabra [UNIFESP]2015-06-14T13:31:39Z2015-06-14T13:31:39Z2005-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1053-1059application/pdfhttp://dx.doi.org/10.1590/S0100-879X2005000700008Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 7, p. 1053-1059, 2005.10.1590/S0100-879X2005000700008S0100-879X2005000700008.pdf0100-879XS0100-879X2005000700008http://repositorio.unifesp.br/handle/11600/2592WOS:000230829900008engBrazilian Journal of Medical and Biological Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-05T23:17:02Zoai:repositorio.unifesp.br/:11600/2592Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-05T23:17:02Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
title Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
spellingShingle Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
Smith, Marilia de Arruda Cardoso [UNIFESP]
WRN: codon 1367 polymorphism
Age-related morbidities
Elderly cohort study
title_short Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
title_full Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
title_fullStr Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
title_full_unstemmed Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
title_sort Frequency of Werner helicase 1367 polymorphism and age-related morbidity in an elderly Brazilian population
author Smith, Marilia de Arruda Cardoso [UNIFESP]
author_facet Smith, Marilia de Arruda Cardoso [UNIFESP]
Silva, M.d.a. [UNIFESP]
Araujo, Lara Miguel Quirino [UNIFESP]
Ramos, Luiz Roberto [UNIFESP]
Lábio, Roger Willian de
Burbano, Rommel Rodríguez [UNIFESP]
Peres, Clovis de Araujo [UNIFESP]
Andreoli, Sergio Baxter [UNIFESP]
Payão, Spencer Luiz Marques [UNIFESP]
Cendoroglo, Maysa Seabra [UNIFESP]
author_role author
author2 Silva, M.d.a. [UNIFESP]
Araujo, Lara Miguel Quirino [UNIFESP]
Ramos, Luiz Roberto [UNIFESP]
Lábio, Roger Willian de
Burbano, Rommel Rodríguez [UNIFESP]
Peres, Clovis de Araujo [UNIFESP]
Andreoli, Sergio Baxter [UNIFESP]
Payão, Spencer Luiz Marques [UNIFESP]
Cendoroglo, Maysa Seabra [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Faculdade de Medicina de Marília Hemocentro Disciplina de Genética e Biologia Molecular
dc.contributor.author.fl_str_mv Smith, Marilia de Arruda Cardoso [UNIFESP]
Silva, M.d.a. [UNIFESP]
Araujo, Lara Miguel Quirino [UNIFESP]
Ramos, Luiz Roberto [UNIFESP]
Lábio, Roger Willian de
Burbano, Rommel Rodríguez [UNIFESP]
Peres, Clovis de Araujo [UNIFESP]
Andreoli, Sergio Baxter [UNIFESP]
Payão, Spencer Luiz Marques [UNIFESP]
Cendoroglo, Maysa Seabra [UNIFESP]
dc.subject.por.fl_str_mv WRN: codon 1367 polymorphism
Age-related morbidities
Elderly cohort study
topic WRN: codon 1367 polymorphism
Age-related morbidities
Elderly cohort study
description Werner syndrome (WS) is a premature aging disease caused by a mutation in the WRN gene. The gene was identified in 1996 and its product acts as a DNA helicase and exonuclease. Some specific WRN polymorphic variants were associated with increased risk for cardiovascular diseases. The identification of genetic polymorphisms as risk factors for complex diseases affecting older people can improve their prevention, diagnosis and prognosis. We investigated WRN codon 1367 polymorphism in 383 residents in a district of the city of São Paulo, who were enrolled in an Elderly Brazilian Longitudinal Study. Their mean age was 79.70 ± 5.32 years, ranging from 67 to 97. This population was composed of 262 females (68.4%) and 121 males (31.6%) of European (89.2%), Japanese (3.3%), Middle Eastern (1.81%), and mixed and/or other origins (5.7%). There are no studies concerning this polymorphism in Brazilian population. These subjects were evaluated clinically every two years. The major health problems and morbidities affecting this cohort were cardiovascular diseases (21.7%), hypertension (83.7%), diabetes (63.3%), obesity (41.23%), dementia (8.0%), depression (20.0%), and neoplasia (10.8%). Their prevalence is similar to some urban elderly Brazilian samples. DNA was isolated from blood cells, amplified by PCR and digested with PmaCI. Allele frequencies were 0.788 for the cysteine and 0.211 for the arginine. Genotype distributions were within that expected for the Hardy-Weinberg equilibrium. Female gender was associated with hypertension and obesity. Logistic regression analysis did not detect significant association between the polymorphism and morbidity. These findings confirm those from Europeans and differ from Japanese population.
publishDate 2005
dc.date.none.fl_str_mv 2005-07-01
2015-06-14T13:31:39Z
2015-06-14T13:31:39Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-879X2005000700008
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 7, p. 1053-1059, 2005.
10.1590/S0100-879X2005000700008
S0100-879X2005000700008.pdf
0100-879X
S0100-879X2005000700008
http://repositorio.unifesp.br/handle/11600/2592
WOS:000230829900008
url http://dx.doi.org/10.1590/S0100-879X2005000700008
http://repositorio.unifesp.br/handle/11600/2592
identifier_str_mv Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 38, n. 7, p. 1053-1059, 2005.
10.1590/S0100-879X2005000700008
S0100-879X2005000700008.pdf
0100-879X
S0100-879X2005000700008
WOS:000230829900008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Medical and Biological Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1053-1059
application/pdf
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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