Terpinen-4-ol, tyrosol, and beta-lapachone as potential antifungals against dimorphic fungi

• Autor(a) principal: Nogueira Brilhante, Raimunda Samia
• Data de Publicação: 2016
• Outros Autores: Caetano, Erica Pacheco, Chaves de Lima, Rita Amanda, de Farias Marques, Francisca Jakelyne, Collares Maia Castelo-Branco, Debora de Souza, Silva de Melo, Charlline Vladia, de Melo Guedes, Glaucia Morgana, de Oliveira, Jonathas Sales, Camargo, Zoilo Pires de [UNIFESP], Bezerra Moreira, Jose Luciano, Monteiro, Andre Jalles, Pinheiro Gomes Bandeira, Tereza de Jesus, Cordeiro, Rossana de Aguiar, Gadelha Rocha, Marcos Fabio, Costa Sidrim, Jose Julio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.bjm.2016.07.015; https://repositorio.unifesp.br/handle/11600/56960
• topic: Dimorphic fungi; Terpinen-4-ol; Tyrosol; beta-Lapachone; Inhibitory effect

This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and beta-lapachone against strains of Coccidioides posadasii in filamentous phase (n=22) and Histoplasma capsulatum in both filamentous (n=40) and yeast phases (n=13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following ranges: 350-5720 mu g/mL, 20-2860 mu g/mL, and 40-1420 mu g/mL, respectively for terpinen-4-ol