Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil

Detalhes bibliográficos
Autor(a) principal: Calvo, Belinda [UNIFESP]
Data de Publicação: 1991
Outros Autores: Gompertz, Olga Fischman [UNIFESP], Castelo Filho, Adauto [UNIFESP], Reis Filho, João Baptista dos [UNIFESP], Del Bianco, Rosana [UNIFESP], Barbosa, Regina Maria, Zaror, Luis Conrado [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/288
http://dx.doi.org/10.1590/S0036-46651991000600009
Resumo: Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery.
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spelling Calvo, Belinda [UNIFESP]Gompertz, Olga Fischman [UNIFESP]Castelo Filho, Adauto [UNIFESP]Reis Filho, João Baptista dos [UNIFESP]Del Bianco, Rosana [UNIFESP]Barbosa, Regina MariaZaror, Luis Conrado [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Hospital Emílio RibasHospital Servidor Público Estadual Francisco Morato de Oliveira2015-06-14T13:24:22Z2015-06-14T13:24:22Z1991-12-01CALVO, Belinda et al . Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 33, n. 6, p. 485-490, dez. 19910036-4665http://repositorio.unifesp.br/handle/11600/288http://dx.doi.org/10.1590/S0036-46651991000600009S0036-46651991000600009.pdfS0036-4665199100060000910.1590/S0036-46651991000600009WOS:A1991HF79200010Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery.Antígeno del polisacárido capsular (Ag PC) de Cryptococcus neoformans fue detectado por la técnica de aglutinación de latex (AL) en LCR y suero de pacientes con Sindrome de Inmunodeficiencia Adquirida (SIDA) y primer episodio de neurocriptococosis, usando como patrón el examen micológico (examen directo y cultivo) de LCR. Se obtuvo una sensibilidad del 100% de AL para detectar AgPC de C. neoformans, el cual por su rápidez permite tratamiento específico precoz. Títulos iniciales de AgPC de la levadura en esos pacientes pueden ser > 1.000.000, pareciendo que cuando esos títulos están presentes en suero, se relacionan con mortalidad durante el tratamiento. En los pacientes que sobrevivieron se observó que el examen micológico directo y AgPC de C. neoformans, en LCR y suero, permanecen positivos aún después de tratamiento y mejoría clínica del paciente.Escola Paulista de Medicina Enfermedades Infecciosas y ParasitariasHospital Emílio RibasHospital Servidor Público Estadual Francisco Morato de OliveiraUNIFESP, EPM, Enfermedades Infecciosas y ParasitariasSciELO485-490engInstituto de Medicina TropicalRevista do Instituto de Medicina Tropical de São PauloDeteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, BrasilDetection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0036-46651991000600009.pdfapplication/pdf440568${dspace.ui.url}/bitstream/11600/288/1/S0036-46651991000600009.pdf52e97890efc615771f7b25ac6b74b1feMD51open accessTEXTS0036-46651991000600009.pdf.txtS0036-46651991000600009.pdf.txtExtracted texttext/plain6${dspace.ui.url}/bitstream/11600/288/2/S0036-46651991000600009.pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD52open access11600/2882021-10-04 21:27:09.687open accessoai:repositorio.unifesp.br:11600/288Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-05T00:27:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
dc.title.alternative.en.fl_str_mv Detection of capsular polysaccharide antigen of Cryptococcus neoformans in patients with AIDS and neurocryptococcosis
title Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
spellingShingle Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
Calvo, Belinda [UNIFESP]
title_short Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
title_full Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
title_fullStr Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
title_full_unstemmed Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
title_sort Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil
author Calvo, Belinda [UNIFESP]
author_facet Calvo, Belinda [UNIFESP]
Gompertz, Olga Fischman [UNIFESP]
Castelo Filho, Adauto [UNIFESP]
Reis Filho, João Baptista dos [UNIFESP]
Del Bianco, Rosana [UNIFESP]
Barbosa, Regina Maria
Zaror, Luis Conrado [UNIFESP]
author_role author
author2 Gompertz, Olga Fischman [UNIFESP]
Castelo Filho, Adauto [UNIFESP]
Reis Filho, João Baptista dos [UNIFESP]
Del Bianco, Rosana [UNIFESP]
Barbosa, Regina Maria
Zaror, Luis Conrado [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Hospital Emílio Ribas
Hospital Servidor Público Estadual Francisco Morato de Oliveira
dc.contributor.author.fl_str_mv Calvo, Belinda [UNIFESP]
Gompertz, Olga Fischman [UNIFESP]
Castelo Filho, Adauto [UNIFESP]
Reis Filho, João Baptista dos [UNIFESP]
Del Bianco, Rosana [UNIFESP]
Barbosa, Regina Maria
Zaror, Luis Conrado [UNIFESP]
description Capsular polysaccharide antigen (AgPC) of Cryptococcus neoformans was detected by latex agglutination technique (LA) in cerebrospinal fluid and serum of patients with AIDS during their first central nervous system manifestation of the disease. Direct mycological examination and culture were used as controls. Sensitivity was 100% by LA allowing an early specific treatment of cryptococcosis. Initial titres of AgPC in such patients can be > 1000000 and it appears that when such titres are present in the serum they are related to mortality during treatment. Surviving patients showed positivity of the direct mycological examination and AgPC of C. neoformans in cerebrospinal fluid and sera even after treatment and clinical recovery.
publishDate 1991
dc.date.issued.fl_str_mv 1991-12-01
dc.date.accessioned.fl_str_mv 2015-06-14T13:24:22Z
dc.date.available.fl_str_mv 2015-06-14T13:24:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv CALVO, Belinda et al . Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 33, n. 6, p. 485-490, dez. 1991
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/288
http://dx.doi.org/10.1590/S0036-46651991000600009
dc.identifier.issn.none.fl_str_mv 0036-4665
dc.identifier.file.none.fl_str_mv S0036-46651991000600009.pdf
dc.identifier.scielo.none.fl_str_mv S0036-46651991000600009
dc.identifier.doi.none.fl_str_mv 10.1590/S0036-46651991000600009
dc.identifier.wos.none.fl_str_mv WOS:A1991HF79200010
identifier_str_mv CALVO, Belinda et al . Deteccion de antigeno del polisacarido capsular de Cryptococcus neoformans en pacientes con SIDA y neurocriptococosis en São Paulo, Brasil. Rev. Inst. Med. trop. S. Paulo, São Paulo , v. 33, n. 6, p. 485-490, dez. 1991
0036-4665
S0036-46651991000600009.pdf
S0036-46651991000600009
10.1590/S0036-46651991000600009
WOS:A1991HF79200010
url http://repositorio.unifesp.br/handle/11600/288
http://dx.doi.org/10.1590/S0036-46651991000600009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Revista do Instituto de Medicina Tropical de São Paulo
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.format.none.fl_str_mv 485-490
dc.publisher.none.fl_str_mv Instituto de Medicina Tropical
publisher.none.fl_str_mv Instituto de Medicina Tropical
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reponame_str Repositório Institucional da UNIFESP
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