Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/26689 http://dx.doi.org/10.1086/324668 |
Resumo: | Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)-alpha, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean +/- SD, 7.8 +/- 7.6 mug Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean +/- SD) of TNF-alpha (1349.3 +/- 767.6 pg/mL), interleukin (IL)-1 (2683 +/- 1270 mug/mL), and IL-6 (382 +/- 52.3 pg/mL) were elevated in PBMC. Serum TNF-alpha levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-gamma levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis. |
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Jesus, A. R. deSilva, A.Santana, L. B.Magalhaes, A.Jesus, A. A. deAlmeida, R. P. deRego, MAVBurattini, Marcelo Nascimento [UNIFESP]Pearce, E. J.Carvalho, E. M.Universidade Federal da Bahia (UFBA)Univ Fed SergipeUniversidade Federal de São Paulo (UNIFESP)Cornell Univ2016-01-24T12:33:10Z2016-01-24T12:33:10Z2002-01-01Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 185, n. 1, p. 98-105, 2002.0022-1899http://repositorio.unifesp.br/handle/11600/26689http://dx.doi.org/10.1086/324668WOS000172722600013.pdf10.1086/324668WOS:000172722600013Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)-alpha, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean +/- SD, 7.8 +/- 7.6 mug Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean +/- SD) of TNF-alpha (1349.3 +/- 767.6 pg/mL), interleukin (IL)-1 (2683 +/- 1270 mug/mL), and IL-6 (382 +/- 52.3 pg/mL) were elevated in PBMC. Serum TNF-alpha levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-gamma levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis.Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Serv Imunol, BR-40110160 Salvador, BrazilUniv Fed Sergipe, Dept Doencas Infecciosas, Sergipe, BrazilUniversidade Federal de São Paulo, Serv Doencas Infecciosas, São Paulo, BrazilCornell Univ, Coll Vet Med, Dept Microbiol Immunol & Parasitol, Ithaca, NY 14853 USAUniversidade Federal de São Paulo, Serv Doencas Infecciosas, São Paulo, BrazilWeb of Science98-105engUniv Chicago PressJournal of Infectious DiseasesClinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000172722600013.pdfapplication/pdf148112${dspace.ui.url}/bitstream/11600/26689/1/WOS000172722600013.pdfe82f4fe09a83af13b0e2ea9483d8c437MD51open accessTEXTWOS000172722600013.pdf.txtWOS000172722600013.pdf.txtExtracted texttext/plain41152${dspace.ui.url}/bitstream/11600/26689/2/WOS000172722600013.pdf.txtd8b5caa4f2788144e780717943bfe973MD52open access11600/266892022-11-04 14:18:39.79open accessoai:repositorio.unifesp.br:11600/26689Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-04T17:18:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni |
title |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni |
spellingShingle |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni Jesus, A. R. de |
title_short |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni |
title_full |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni |
title_fullStr |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni |
title_full_unstemmed |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni |
title_sort |
Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni |
author |
Jesus, A. R. de |
author_facet |
Jesus, A. R. de Silva, A. Santana, L. B. Magalhaes, A. Jesus, A. A. de Almeida, R. P. de Rego, MAV Burattini, Marcelo Nascimento [UNIFESP] Pearce, E. J. Carvalho, E. M. |
author_role |
author |
author2 |
Silva, A. Santana, L. B. Magalhaes, A. Jesus, A. A. de Almeida, R. P. de Rego, MAV Burattini, Marcelo Nascimento [UNIFESP] Pearce, E. J. Carvalho, E. M. |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal da Bahia (UFBA) Univ Fed Sergipe Universidade Federal de São Paulo (UNIFESP) Cornell Univ |
dc.contributor.author.fl_str_mv |
Jesus, A. R. de Silva, A. Santana, L. B. Magalhaes, A. Jesus, A. A. de Almeida, R. P. de Rego, MAV Burattini, Marcelo Nascimento [UNIFESP] Pearce, E. J. Carvalho, E. M. |
description |
Thirty-one patients with acute schistosomiasis were evaluated clinically and immunologically. Cytokine levels were determined in peripheral blood mononuclear cell (PBMC) supernatants. Levels of total and antigen-specific IgE, tumor necrosis factor (TNF)-alpha, and immune complexes were measured in serum samples. Clinical findings included general symptoms, liver damage, pulmonary involvement, and pericarditis. All patients had eosinophilia. Immune complexes were detected in 55% of the patients (mean +/- SD, 7.8 +/- 7.6 mug Eq/mL) and were associated with cough, dyspnea, and abnormal chest radiographic findings. Levels (mean +/- SD) of TNF-alpha (1349.3 +/- 767.6 pg/mL), interleukin (IL)-1 (2683 +/- 1270 mug/mL), and IL-6 (382 +/- 52.3 pg/mL) were elevated in PBMC. Serum TNF-alpha levels were elevated in 87% of the patients and were associated with abdominal pain. Higher interferon-gamma levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease. Low IL-5 levels were associated with weight loss. Proinflammatory cytokines and immune complexes with low Th2 responses might explain the immunopathogenesis of acute schistosomiasis. |
publishDate |
2002 |
dc.date.issued.fl_str_mv |
2002-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:33:10Z |
dc.date.available.fl_str_mv |
2016-01-24T12:33:10Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 185, n. 1, p. 98-105, 2002. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/26689 http://dx.doi.org/10.1086/324668 |
dc.identifier.issn.none.fl_str_mv |
0022-1899 |
dc.identifier.file.none.fl_str_mv |
WOS000172722600013.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1086/324668 |
dc.identifier.wos.none.fl_str_mv |
WOS:000172722600013 |
identifier_str_mv |
Journal of Infectious Diseases. Chicago: Univ Chicago Press, v. 185, n. 1, p. 98-105, 2002. 0022-1899 WOS000172722600013.pdf 10.1086/324668 WOS:000172722600013 |
url |
http://repositorio.unifesp.br/handle/11600/26689 http://dx.doi.org/10.1086/324668 |
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eng |
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Univ Chicago Press |
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Univ Chicago Press |
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