Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/001300000fztx |
Texto Completo: | https://dx.doi.org/10.1155/2018/4682876 https://repositorio.unifesp.br/handle/11600/53866 |
Resumo: | Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles |
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Repositório Institucional da UNIFESP |
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Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult PatientEctopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small folliclesone sample exhibited a normal thyroid pattern while four showed colloid goiter. All ectopic thyroids expressed the specific thyroid genes and T4 at similar locations to those observed in normal thyroid. No somatic mutations associated with ectopic thyroid were found. This is the first immature thyroid fetal tissue observed in an ectopic thyroid due to the arrest of structural differentiation early in the colloid stage of development that proved able to synthesize thyroid hormone but not to respond to TSH. Despite the ability of all ectopic thyroids to synthetize specific thyroid proteins and T4, at some point in life, it may be insufficient to support body growth leading to hypothyroidism, as observed in some of the patients.Univ Sao Paulo FMUSP, Fac Med, Cellular & Mol Endocrine Lab, Thyroid Unit,LIM 25, Ave Doutor Arnaldo 455, BR-01246904 Sao Paulo, SP, BrazilSao Paulo Publ Hlth Serv, Adolfo Lutz Inst, Av Dr Arnaldo 355, BR-01246000 Sao Paulo, SP, BrazilHead & Neck Surg Santa Catarina Hosp, Av Paulista 200, BR-01310000 Sao Paulo, SP, BrazilUNESP, Botucatu Sch Med, Dept Internal Med, Av Prof Montenegro,S-N Dist Rubiao Jr, BR-18618687 Botucatu, SP, BrazilHosp Pediat Dr Juan Garrahan, Serv Endocrinol, Combate Pozos 1881,C1245AAM, Buenos Aires, DF, ArgentinaUniv Estadual Campinas, Fac Ciencias Med, Dept Cirurgia, Disciplina Cirurgia Cabeca & Pescoco, R Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP, BrazilUniv Fortaleza Unifor, Med Sch, Av Washington Soares 1321, BR-60811905 Fortaleza, CE, BrazilUniv Fed Sao Paulo UNIFESP, Postgrad Program Biotechnol, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Programs Biotechnol & Struct & Funct Bio, Dept Ciencias Biol, Thyroid Mol Sci Lab,UNIFESP, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilHosp Sirio Libanes, Mol Oncol Ctr, Rua Prof Daher Cutait 69, BR-01308060 Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Postgrad Program Biotechnol, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Programs Biotechnol & Struct & Funct Bio, Dept Ciencias Biol, Thyroid Mol Sci Lab,UNIFESP, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Instituto da TiroideFAPESP: 2009/53840-0FAPESP: 2010/12005-9FAPESP: 2014/24549-4Hindawi Ltd2020-07-02T18:52:04Z2020-07-02T18:52:04Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttps://dx.doi.org/10.1155/2018/4682876International Journal Of Endocrinology. London, v. , p. -, 2018.10.1155/2018/4682876WOS000425414300001.pdf1687-8337https://repositorio.unifesp.br/handle/11600/53866WOS:000425414300001ark:/48912/001300000fztxengInternational Journal Of EndocrinologyLondoninfo:eu-repo/semantics/openAccessCamargo, Rosalinda Yossie Asato deKanamura, Cristina TakamiFriguglietti, Celso UbirajaraNogueira, Celia ReginaIorcansky, SoniaTincani, Alfio JoseBezerra, Ana KarinaBrust, EsterKoyama, Fernanda ChristtaniniCamargo, Anamaria AranhaRego, Fernanda Orpinelli Ramos doGalante, Pedro Alexandre FavorettoMedeiros-Neto, GeraldoRubio, Ileana Gabriela Sanchez de [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T04:06:44Zoai:repositorio.unifesp.br/:11600/53866Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:16:07.702942Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient |
title |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient |
spellingShingle |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient Camargo, Rosalinda Yossie Asato de |
title_short |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient |
title_full |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient |
title_fullStr |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient |
title_full_unstemmed |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient |
title_sort |
Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient |
author |
Camargo, Rosalinda Yossie Asato de |
author_facet |
Camargo, Rosalinda Yossie Asato de Kanamura, Cristina Takami Friguglietti, Celso Ubirajara Nogueira, Celia Regina Iorcansky, Sonia Tincani, Alfio Jose Bezerra, Ana Karina Brust, Ester Koyama, Fernanda Christtanini Camargo, Anamaria Aranha Rego, Fernanda Orpinelli Ramos do Galante, Pedro Alexandre Favoretto Medeiros-Neto, Geraldo Rubio, Ileana Gabriela Sanchez de [UNIFESP] |
author_role |
author |
author2 |
Kanamura, Cristina Takami Friguglietti, Celso Ubirajara Nogueira, Celia Regina Iorcansky, Sonia Tincani, Alfio Jose Bezerra, Ana Karina Brust, Ester Koyama, Fernanda Christtanini Camargo, Anamaria Aranha Rego, Fernanda Orpinelli Ramos do Galante, Pedro Alexandre Favoretto Medeiros-Neto, Geraldo Rubio, Ileana Gabriela Sanchez de [UNIFESP] |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Camargo, Rosalinda Yossie Asato de Kanamura, Cristina Takami Friguglietti, Celso Ubirajara Nogueira, Celia Regina Iorcansky, Sonia Tincani, Alfio Jose Bezerra, Ana Karina Brust, Ester Koyama, Fernanda Christtanini Camargo, Anamaria Aranha Rego, Fernanda Orpinelli Ramos do Galante, Pedro Alexandre Favoretto Medeiros-Neto, Geraldo Rubio, Ileana Gabriela Sanchez de [UNIFESP] |
description |
Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2020-07-02T18:52:04Z 2020-07-02T18:52:04Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://dx.doi.org/10.1155/2018/4682876 International Journal Of Endocrinology. London, v. , p. -, 2018. 10.1155/2018/4682876 WOS000425414300001.pdf 1687-8337 https://repositorio.unifesp.br/handle/11600/53866 WOS:000425414300001 |
dc.identifier.dark.fl_str_mv |
ark:/48912/001300000fztx |
url |
https://dx.doi.org/10.1155/2018/4682876 https://repositorio.unifesp.br/handle/11600/53866 |
identifier_str_mv |
International Journal Of Endocrinology. London, v. , p. -, 2018. 10.1155/2018/4682876 WOS000425414300001.pdf 1687-8337 WOS:000425414300001 ark:/48912/001300000fztx |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal Of Endocrinology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
- application/pdf |
dc.coverage.none.fl_str_mv |
London |
dc.publisher.none.fl_str_mv |
Hindawi Ltd |
publisher.none.fl_str_mv |
Hindawi Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1818602458294779904 |