Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient

Detalhes bibliográficos
Autor(a) principal: Camargo, Rosalinda Yossie Asato de
Data de Publicação: 2018
Outros Autores: Kanamura, Cristina Takami, Friguglietti, Celso Ubirajara, Nogueira, Celia Regina, Iorcansky, Sonia, Tincani, Alfio Jose, Bezerra, Ana Karina, Brust, Ester, Koyama, Fernanda Christtanini, Camargo, Anamaria Aranha, Rego, Fernanda Orpinelli Ramos do, Galante, Pedro Alexandre Favoretto, Medeiros-Neto, Geraldo, Rubio, Ileana Gabriela Sanchez de [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300000fztx
Texto Completo: https://dx.doi.org/10.1155/2018/4682876
https://repositorio.unifesp.br/handle/11600/53866
Resumo: Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles
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spelling Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult PatientEctopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small folliclesone sample exhibited a normal thyroid pattern while four showed colloid goiter. All ectopic thyroids expressed the specific thyroid genes and T4 at similar locations to those observed in normal thyroid. No somatic mutations associated with ectopic thyroid were found. This is the first immature thyroid fetal tissue observed in an ectopic thyroid due to the arrest of structural differentiation early in the colloid stage of development that proved able to synthesize thyroid hormone but not to respond to TSH. Despite the ability of all ectopic thyroids to synthetize specific thyroid proteins and T4, at some point in life, it may be insufficient to support body growth leading to hypothyroidism, as observed in some of the patients.Univ Sao Paulo FMUSP, Fac Med, Cellular & Mol Endocrine Lab, Thyroid Unit,LIM 25, Ave Doutor Arnaldo 455, BR-01246904 Sao Paulo, SP, BrazilSao Paulo Publ Hlth Serv, Adolfo Lutz Inst, Av Dr Arnaldo 355, BR-01246000 Sao Paulo, SP, BrazilHead & Neck Surg Santa Catarina Hosp, Av Paulista 200, BR-01310000 Sao Paulo, SP, BrazilUNESP, Botucatu Sch Med, Dept Internal Med, Av Prof Montenegro,S-N Dist Rubiao Jr, BR-18618687 Botucatu, SP, BrazilHosp Pediat Dr Juan Garrahan, Serv Endocrinol, Combate Pozos 1881,C1245AAM, Buenos Aires, DF, ArgentinaUniv Estadual Campinas, Fac Ciencias Med, Dept Cirurgia, Disciplina Cirurgia Cabeca & Pescoco, R Tessalia Vieira Camargo 126, BR-13083887 Campinas, SP, BrazilUniv Fortaleza Unifor, Med Sch, Av Washington Soares 1321, BR-60811905 Fortaleza, CE, BrazilUniv Fed Sao Paulo UNIFESP, Postgrad Program Biotechnol, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Programs Biotechnol & Struct & Funct Bio, Dept Ciencias Biol, Thyroid Mol Sci Lab,UNIFESP, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilHosp Sirio Libanes, Mol Oncol Ctr, Rua Prof Daher Cutait 69, BR-01308060 Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Postgrad Program Biotechnol, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Postgrad Programs Biotechnol & Struct & Funct Bio, Dept Ciencias Biol, Thyroid Mol Sci Lab,UNIFESP, Pedro Toledo 669, BR-04039903 Sao Paulo, SP, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Instituto da TiroideFAPESP: 2009/53840-0FAPESP: 2010/12005-9FAPESP: 2014/24549-4Hindawi Ltd2020-07-02T18:52:04Z2020-07-02T18:52:04Z2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttps://dx.doi.org/10.1155/2018/4682876International Journal Of Endocrinology. London, v. , p. -, 2018.10.1155/2018/4682876WOS000425414300001.pdf1687-8337https://repositorio.unifesp.br/handle/11600/53866WOS:000425414300001ark:/48912/001300000fztxengInternational Journal Of EndocrinologyLondoninfo:eu-repo/semantics/openAccessCamargo, Rosalinda Yossie Asato deKanamura, Cristina TakamiFriguglietti, Celso UbirajaraNogueira, Celia ReginaIorcansky, SoniaTincani, Alfio JoseBezerra, Ana KarinaBrust, EsterKoyama, Fernanda ChristtaniniCamargo, Anamaria AranhaRego, Fernanda Orpinelli Ramos doGalante, Pedro Alexandre FavorettoMedeiros-Neto, GeraldoRubio, Ileana Gabriela Sanchez de [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-11T04:06:44Zoai:repositorio.unifesp.br/:11600/53866Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:16:07.702942Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
title Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
spellingShingle Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
Camargo, Rosalinda Yossie Asato de
title_short Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
title_full Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
title_fullStr Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
title_full_unstemmed Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
title_sort Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient
author Camargo, Rosalinda Yossie Asato de
author_facet Camargo, Rosalinda Yossie Asato de
Kanamura, Cristina Takami
Friguglietti, Celso Ubirajara
Nogueira, Celia Regina
Iorcansky, Sonia
Tincani, Alfio Jose
Bezerra, Ana Karina
Brust, Ester
Koyama, Fernanda Christtanini
Camargo, Anamaria Aranha
Rego, Fernanda Orpinelli Ramos do
Galante, Pedro Alexandre Favoretto
Medeiros-Neto, Geraldo
Rubio, Ileana Gabriela Sanchez de [UNIFESP]
author_role author
author2 Kanamura, Cristina Takami
Friguglietti, Celso Ubirajara
Nogueira, Celia Regina
Iorcansky, Sonia
Tincani, Alfio Jose
Bezerra, Ana Karina
Brust, Ester
Koyama, Fernanda Christtanini
Camargo, Anamaria Aranha
Rego, Fernanda Orpinelli Ramos do
Galante, Pedro Alexandre Favoretto
Medeiros-Neto, Geraldo
Rubio, Ileana Gabriela Sanchez de [UNIFESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Camargo, Rosalinda Yossie Asato de
Kanamura, Cristina Takami
Friguglietti, Celso Ubirajara
Nogueira, Celia Regina
Iorcansky, Sonia
Tincani, Alfio Jose
Bezerra, Ana Karina
Brust, Ester
Koyama, Fernanda Christtanini
Camargo, Anamaria Aranha
Rego, Fernanda Orpinelli Ramos do
Galante, Pedro Alexandre Favoretto
Medeiros-Neto, Geraldo
Rubio, Ileana Gabriela Sanchez de [UNIFESP]
description Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Six samples were histologically examined, and the expression of the specific thyroid proteins was assessed by immunohistochemistry. Two samples were submitted to whole exome sequencing. An oropharynx sample showed immature fetal architecture tissue with clusters or cords of oval thyrocytes and small follicles
publishDate 2018
dc.date.none.fl_str_mv 2018
2020-07-02T18:52:04Z
2020-07-02T18:52:04Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://dx.doi.org/10.1155/2018/4682876
International Journal Of Endocrinology. London, v. , p. -, 2018.
10.1155/2018/4682876
WOS000425414300001.pdf
1687-8337
https://repositorio.unifesp.br/handle/11600/53866
WOS:000425414300001
dc.identifier.dark.fl_str_mv ark:/48912/001300000fztx
url https://dx.doi.org/10.1155/2018/4682876
https://repositorio.unifesp.br/handle/11600/53866
identifier_str_mv International Journal Of Endocrinology. London, v. , p. -, 2018.
10.1155/2018/4682876
WOS000425414300001.pdf
1687-8337
WOS:000425414300001
ark:/48912/001300000fztx
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Journal Of Endocrinology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
application/pdf
dc.coverage.none.fl_str_mv London
dc.publisher.none.fl_str_mv Hindawi Ltd
publisher.none.fl_str_mv Hindawi Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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