Acuidade visual e função de bastonetes em pacientes com retinose pigmentária

• Autor(a) principal: Berezovsky, Adriana [UNIFESP]
• Data de Publicação: 2004
• Outros Autores: Pereira, Josenilson Martins [UNIFESP], Sacai, Paula Yuri [UNIFESP], Fantini, Sérgio Costa [UNIFESP], Salomão, Solange Rios [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-27492004000500010; http://repositorio.unifesp.br/handle/11600/2224
• topic: Visual acuity; Visual fields; Retinitis pigmentosa; Rods (Retina); Electroretinography; Dark adaptation; Electrophysiology; Acuidade visual; Campos visuais; Retinite pigmentosa; Bastonetes (Retina); Eletrorretinografia; Adaptação à escuridão; Eletrofisiologia

PURPOSE: To investigate visual acuity and rod function, and correlate them to different clinical parameters in patients with retinitis pigmentosa (RP). METHODS: A cohort of 199 patients with retinitis pigmentosa (110 males and 89 females), aged 6-79 years (mean = 36.8±17.5) had their monocular visual acuity measured by the ETDRS chart and rod function assessed by full-field electroretinogram and dark-adapted thresholds. The distribution of different genetic subtypes of retinitis pigmentosa was 20.3% autosomal dominant, 14.2% X - linked, 24.2% autosomal recessive and 41.3% isolated. History of consanguinity was found in 41 (20.6%) patients. Forty-one patients (20.6%) were 20 years old or less, 77 (38.6%) ranged from 21 - 40 years, 61 (30.7%) from 41 - 60 years, and 20 (10.1%) were 61 years or older. Peak-to-peak amplitude and b-wave implicit time were measured and statistically analyzed (one-way ANOVA). Pearson correlation was performed between rod amplitude and dark-adapted thereshold and rod amplitude and visual acuity. RESULTS: Analyzing the visual acuity data according to genetic subtypes, without considering age, showed that as a group, patients with autosomal recessive and isolated retinitis pigmentosa have less severe impairment of visual acuity, than those with X-linked retinitis pigmentosa. Nyctalopia begun earlier in X-linked groups, compared with the remaining groups (p=0.011). A negative correlation was found between dark-adapted thereshold and scotopic rod amplitude (Pearson correlation coefficient = - 0.772 and P =0.000). There were no significant relationships between visual acuity and rod response by electroretinogram (Pearson correlation coefficient = 0.0815 and P = 0.286), P > 0.050. CONCLUSIONS: In a cohort of retinitis pigmentosa patients, 31.2% had vision of 20/40 or better. Rod function loss was highly correlated when assessed electrophysiologically (ERG) and psychophysically (dark-adapted thershold). No correlation was found between rod response measured by electroretinogram and visual acuity.