Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/37139 https://dx.doi.org/10.1155/2014/487129 |
Resumo: | Exercise training reduces sympathetic activity in hypertensive humans and rats. We hypothesized that the swimming exercisewould change the neurotransmission in the rostral ventrolateral medulla (RVLM), a key region involved in sympathetic outflow, and hemodynamic control in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Bilateral injections of kynurenic acid (KYN) were carried out in the RVLM in sedentary- (S-) or exercised- (E-) SHR and WKY rats submitted to swimming for 6 weeks. Rats were alpha-chloralose anesthetized and artificially ventilated, with Doppler flow probes around the lower abdominal aorta and superior mesenteric artery. Injections into the RVLM were made before and after i.v. L-NAME (nitric oxide synthase, NOS, inhibitor). Injections of KYN into the RVLM elicited a major vasodilation in the hindlimbmore than in the mesenteric artery in E-SHR compared to S-SHR, but similar decrease in arterial pressure was observed in both groups. Injections of KYN into the RVLM after i.v. L-NAME attenuated the hindlimb vasodilation evoked by KYN and increased the mesenteric vasodilation in ESHR. Swimming exercise can enhance the hindlimb vasodilation mediated by peripheral NO release, reducing the activation of neurons with EAA receptors in the RVLM in SHR. |
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Ogihara, Cristiana Akemi [UNIFESP]Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP]Lazari, Maria de Fatima Magalhaes [UNIFESP]Giannocco, GiseleLopes, Oswaldo Ubriaco [UNIFESP]Colombari, EduardoSato, Monica AkemiFMABCUniversidade Federal de São Paulo (UNIFESP)São Paulo State Univ UNESP2016-01-24T14:34:56Z2016-01-24T14:34:56Z2014-01-01Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014.2314-6133https://repositorio.unifesp.br/handle/11600/37139https://dx.doi.org/10.1155/2014/487129WOS000332283900001.pdf10.1155/2014/487129WOS:000332283900001Exercise training reduces sympathetic activity in hypertensive humans and rats. We hypothesized that the swimming exercisewould change the neurotransmission in the rostral ventrolateral medulla (RVLM), a key region involved in sympathetic outflow, and hemodynamic control in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Bilateral injections of kynurenic acid (KYN) were carried out in the RVLM in sedentary- (S-) or exercised- (E-) SHR and WKY rats submitted to swimming for 6 weeks. Rats were alpha-chloralose anesthetized and artificially ventilated, with Doppler flow probes around the lower abdominal aorta and superior mesenteric artery. Injections into the RVLM were made before and after i.v. L-NAME (nitric oxide synthase, NOS, inhibitor). Injections of KYN into the RVLM elicited a major vasodilation in the hindlimbmore than in the mesenteric artery in E-SHR compared to S-SHR, but similar decrease in arterial pressure was observed in both groups. Injections of KYN into the RVLM after i.v. L-NAME attenuated the hindlimb vasodilation evoked by KYN and increased the mesenteric vasodilation in ESHR. Swimming exercise can enhance the hindlimb vasodilation mediated by peripheral NO release, reducing the activation of neurons with EAA receptors in the RVLM in SHR.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Nucleo de Estudo Pesquisa e Assessoria a Pesquisa da Faculdade de Medicina do ABC (NEPAS, FMABC)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)FMABC, Dept Physiol, BR-09060650 Santo Andre, SP, BrazilFed Univ São Paulo UNIFESP, Dept Physiol, BR-04023901 São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04044020 São Paulo, BrazilSão Paulo State Univ UNESP, Sch Dent, Dept Pathol & Physiol, BR-14801385 Araraquara, SP, BrazilFed Univ São Paulo UNIFESP, Dept Physiol, BR-04023901 São Paulo, BrazilFed Univ São Paulo UNIFESP, Dept Pharmacol, BR-04044020 São Paulo, BrazilFAPESP: 06/60842-1Web of Science9engHindawi Publishing CorporationBiomed Research InternationalSwimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000332283900001.pdfapplication/pdf1891175${dspace.ui.url}/bitstream/11600/37139/1/WOS000332283900001.pdfacf65d4de5449a972a289a59daf8be9cMD51open accessTEXTWOS000332283900001.pdf.txtWOS000332283900001.pdf.txtExtracted texttext/plain45915${dspace.ui.url}/bitstream/11600/37139/2/WOS000332283900001.pdf.txtb1bcd59e85d301447428233c21befbe9MD52open access11600/371392022-10-11 17:19:34.822open accessoai:repositorio.unifesp.br:11600/37139Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:34:19.974516Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats |
title |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats |
spellingShingle |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats Ogihara, Cristiana Akemi [UNIFESP] |
title_short |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats |
title_full |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats |
title_fullStr |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats |
title_full_unstemmed |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats |
title_sort |
Swimming Exercise Changes Hemodynamic Responses Evoked by Blockade of Excitatory Amino Receptors in the Rostral Ventrolateral Medulla in Spontaneously Hypertensive Rats |
author |
Ogihara, Cristiana Akemi [UNIFESP] |
author_facet |
Ogihara, Cristiana Akemi [UNIFESP] Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP] Lazari, Maria de Fatima Magalhaes [UNIFESP] Giannocco, Gisele Lopes, Oswaldo Ubriaco [UNIFESP] Colombari, Eduardo Sato, Monica Akemi |
author_role |
author |
author2 |
Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP] Lazari, Maria de Fatima Magalhaes [UNIFESP] Giannocco, Gisele Lopes, Oswaldo Ubriaco [UNIFESP] Colombari, Eduardo Sato, Monica Akemi |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
FMABC Universidade Federal de São Paulo (UNIFESP) São Paulo State Univ UNESP |
dc.contributor.author.fl_str_mv |
Ogihara, Cristiana Akemi [UNIFESP] Schoorlemmer, Gerhardus Hermanus Maria [UNIFESP] Lazari, Maria de Fatima Magalhaes [UNIFESP] Giannocco, Gisele Lopes, Oswaldo Ubriaco [UNIFESP] Colombari, Eduardo Sato, Monica Akemi |
description |
Exercise training reduces sympathetic activity in hypertensive humans and rats. We hypothesized that the swimming exercisewould change the neurotransmission in the rostral ventrolateral medulla (RVLM), a key region involved in sympathetic outflow, and hemodynamic control in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats. Bilateral injections of kynurenic acid (KYN) were carried out in the RVLM in sedentary- (S-) or exercised- (E-) SHR and WKY rats submitted to swimming for 6 weeks. Rats were alpha-chloralose anesthetized and artificially ventilated, with Doppler flow probes around the lower abdominal aorta and superior mesenteric artery. Injections into the RVLM were made before and after i.v. L-NAME (nitric oxide synthase, NOS, inhibitor). Injections of KYN into the RVLM elicited a major vasodilation in the hindlimbmore than in the mesenteric artery in E-SHR compared to S-SHR, but similar decrease in arterial pressure was observed in both groups. Injections of KYN into the RVLM after i.v. L-NAME attenuated the hindlimb vasodilation evoked by KYN and increased the mesenteric vasodilation in ESHR. Swimming exercise can enhance the hindlimb vasodilation mediated by peripheral NO release, reducing the activation of neurons with EAA receptors in the RVLM in SHR. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:34:56Z |
dc.date.available.fl_str_mv |
2016-01-24T14:34:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/37139 https://dx.doi.org/10.1155/2014/487129 |
dc.identifier.issn.none.fl_str_mv |
2314-6133 |
dc.identifier.file.none.fl_str_mv |
WOS000332283900001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1155/2014/487129 |
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WOS:000332283900001 |
identifier_str_mv |
Biomed Research International. New York: Hindawi Publishing Corporation, 9 p., 2014. 2314-6133 WOS000332283900001.pdf 10.1155/2014/487129 WOS:000332283900001 |
url |
https://repositorio.unifesp.br/handle/11600/37139 https://dx.doi.org/10.1155/2014/487129 |
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eng |
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9 |
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Hindawi Publishing Corporation |
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Hindawi Publishing Corporation |
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