Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers

Detalhes bibliográficos
Autor(a) principal: Barros, Marina Carvalho de Moraes [UNIFESP]
Data de Publicação: 2011
Outros Autores: Mitsuhiro, Sandro Sendin [UNIFESP], Chalem, Elisa [UNIFESP], Laranjeira, Ronaldo [UNIFESP], Guinsburg, Ruth [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1807-59322011000900016
http://repositorio.unifesp.br/handle/11600/6129
Resumo: INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life.
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spelling Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothersTobaccoPrenatal exposure delayed effectsPregnancy in adolescenceInfantNewborn behaviorINTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life.Federal University of São PauloUNIFESP, EPM, São PauloSciELOFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2000/10293-5Faculdade de Medicina / USPUniversidade Federal de São Paulo (UNIFESP)Barros, Marina Carvalho de Moraes [UNIFESP]Mitsuhiro, Sandro Sendin [UNIFESP]Chalem, Elisa [UNIFESP]Laranjeira, Ronaldo [UNIFESP]Guinsburg, Ruth [UNIFESP]2015-06-14T13:42:43Z2015-06-14T13:42:43Z2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1597-1603application/pdfhttp://dx.doi.org/10.1590/S1807-59322011000900016Clinics. Faculdade de Medicina / USP, v. 66, n. 9, p. 1597-1603, 2011.10.1590/S1807-59322011000900016S1807-59322011000900016.pdf1807-5932S1807-59322011000900016http://repositorio.unifesp.br/handle/11600/6129WOS:000297498400016engClinicsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T09:52:13Zoai:repositorio.unifesp.br/:11600/6129Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-06T09:52:13Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
spellingShingle Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
Barros, Marina Carvalho de Moraes [UNIFESP]
Tobacco
Prenatal exposure delayed effects
Pregnancy in adolescence
Infant
Newborn behavior
title_short Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_full Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_fullStr Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_full_unstemmed Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_sort Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
author Barros, Marina Carvalho de Moraes [UNIFESP]
author_facet Barros, Marina Carvalho de Moraes [UNIFESP]
Mitsuhiro, Sandro Sendin [UNIFESP]
Chalem, Elisa [UNIFESP]
Laranjeira, Ronaldo [UNIFESP]
Guinsburg, Ruth [UNIFESP]
author_role author
author2 Mitsuhiro, Sandro Sendin [UNIFESP]
Chalem, Elisa [UNIFESP]
Laranjeira, Ronaldo [UNIFESP]
Guinsburg, Ruth [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Barros, Marina Carvalho de Moraes [UNIFESP]
Mitsuhiro, Sandro Sendin [UNIFESP]
Chalem, Elisa [UNIFESP]
Laranjeira, Ronaldo [UNIFESP]
Guinsburg, Ruth [UNIFESP]
dc.subject.por.fl_str_mv Tobacco
Prenatal exposure delayed effects
Pregnancy in adolescence
Infant
Newborn behavior
topic Tobacco
Prenatal exposure delayed effects
Pregnancy in adolescence
Infant
Newborn behavior
description INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
2015-06-14T13:42:43Z
2015-06-14T13:42:43Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1807-59322011000900016
Clinics. Faculdade de Medicina / USP, v. 66, n. 9, p. 1597-1603, 2011.
10.1590/S1807-59322011000900016
S1807-59322011000900016.pdf
1807-5932
S1807-59322011000900016
http://repositorio.unifesp.br/handle/11600/6129
WOS:000297498400016
url http://dx.doi.org/10.1590/S1807-59322011000900016
http://repositorio.unifesp.br/handle/11600/6129
identifier_str_mv Clinics. Faculdade de Medicina / USP, v. 66, n. 9, p. 1597-1603, 2011.
10.1590/S1807-59322011000900016
S1807-59322011000900016.pdf
1807-5932
S1807-59322011000900016
WOS:000297498400016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1597-1603
application/pdf
dc.publisher.none.fl_str_mv Faculdade de Medicina / USP
publisher.none.fl_str_mv Faculdade de Medicina / USP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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