Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Clinics |
Texto Completo: | https://www.revistas.usp.br/clinics/article/view/19430 |
Resumo: | INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life. |
id |
USP-19_d48b8b405caa1c6131f654a01449e923 |
---|---|
oai_identifier_str |
oai:revistas.usp.br:article/19430 |
network_acronym_str |
USP-19 |
network_name_str |
Clinics |
repository_id_str |
|
spelling |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers TobaccoPrenatal exposure delayed effectsPregnancy in adolescenceInfantNewborn behavior INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1943010.1590/S1807-59322011000900016Clinics; Vol. 66 No. 9 (2011); 1597-1603 Clinics; v. 66 n. 9 (2011); 1597-1603 Clinics; Vol. 66 Núm. 9 (2011); 1597-1603 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19430/21493Barros, Marina C. M.Mitsuhiro, Sandro SChalem, ElisaLaranjeira, Ronaldo RGuinsburg, Ruthinfo:eu-repo/semantics/openAccess2012-05-23T16:40:30Zoai:revistas.usp.br:article/19430Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:40:30Clinics - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers |
title |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers |
spellingShingle |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers Barros, Marina C. M. Tobacco Prenatal exposure delayed effects Pregnancy in adolescence Infant Newborn behavior |
title_short |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers |
title_full |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers |
title_fullStr |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers |
title_full_unstemmed |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers |
title_sort |
Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers |
author |
Barros, Marina C. M. |
author_facet |
Barros, Marina C. M. Mitsuhiro, Sandro S Chalem, Elisa Laranjeira, Ronaldo R Guinsburg, Ruth |
author_role |
author |
author2 |
Mitsuhiro, Sandro S Chalem, Elisa Laranjeira, Ronaldo R Guinsburg, Ruth |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Barros, Marina C. M. Mitsuhiro, Sandro S Chalem, Elisa Laranjeira, Ronaldo R Guinsburg, Ruth |
dc.subject.por.fl_str_mv |
Tobacco Prenatal exposure delayed effects Pregnancy in adolescence Infant Newborn behavior |
topic |
Tobacco Prenatal exposure delayed effects Pregnancy in adolescence Infant Newborn behavior |
description |
INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19430 10.1590/S1807-59322011000900016 |
url |
https://www.revistas.usp.br/clinics/article/view/19430 |
identifier_str_mv |
10.1590/S1807-59322011000900016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/clinics/article/view/19430/21493 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
publisher.none.fl_str_mv |
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo |
dc.source.none.fl_str_mv |
Clinics; Vol. 66 No. 9 (2011); 1597-1603 Clinics; v. 66 n. 9 (2011); 1597-1603 Clinics; Vol. 66 Núm. 9 (2011); 1597-1603 1980-5322 1807-5932 reponame:Clinics instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Clinics |
collection |
Clinics |
repository.name.fl_str_mv |
Clinics - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||clinics@hc.fm.usp.br |
_version_ |
1800222757263245312 |