Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers

Detalhes bibliográficos
Autor(a) principal: Barros, Marina C. M.
Data de Publicação: 2011
Outros Autores: Mitsuhiro, Sandro S, Chalem, Elisa, Laranjeira, Ronaldo R, Guinsburg, Ruth
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Clinics
Texto Completo: https://www.revistas.usp.br/clinics/article/view/19430
Resumo: INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life.
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spelling Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers TobaccoPrenatal exposure delayed effectsPregnancy in adolescenceInfantNewborn behavior INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life. Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/1943010.1590/S1807-59322011000900016Clinics; Vol. 66 No. 9 (2011); 1597-1603 Clinics; v. 66 n. 9 (2011); 1597-1603 Clinics; Vol. 66 Núm. 9 (2011); 1597-1603 1980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/19430/21493Barros, Marina C. M.Mitsuhiro, Sandro SChalem, ElisaLaranjeira, Ronaldo RGuinsburg, Ruthinfo:eu-repo/semantics/openAccess2012-05-23T16:40:30Zoai:revistas.usp.br:article/19430Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-05-23T16:40:30Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
spellingShingle Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
Barros, Marina C. M.
Tobacco
Prenatal exposure delayed effects
Pregnancy in adolescence
Infant
Newborn behavior
title_short Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_full Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_fullStr Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_full_unstemmed Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
title_sort Prenatal tobacco exposure is related to neurobehavioral modifications in infants of adolescent mothers
author Barros, Marina C. M.
author_facet Barros, Marina C. M.
Mitsuhiro, Sandro S
Chalem, Elisa
Laranjeira, Ronaldo R
Guinsburg, Ruth
author_role author
author2 Mitsuhiro, Sandro S
Chalem, Elisa
Laranjeira, Ronaldo R
Guinsburg, Ruth
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Barros, Marina C. M.
Mitsuhiro, Sandro S
Chalem, Elisa
Laranjeira, Ronaldo R
Guinsburg, Ruth
dc.subject.por.fl_str_mv Tobacco
Prenatal exposure delayed effects
Pregnancy in adolescence
Infant
Newborn behavior
topic Tobacco
Prenatal exposure delayed effects
Pregnancy in adolescence
Infant
Newborn behavior
description INTRODUCTION: Prenatal tobacco exposure interferes with neonatal outcomes. OBJECTIVE: To determine the neonatal neurobehavioral effects of in utero tobacco exposure. METHODS: This prospective cross-sectional study included healthy, term, with birth weight appropriate for gestacional age neonates without exposure to alcohol, drugs, or infections, born to adolescent mothers without psychiatric disorders or post-traumatic stress. Infants were classified according to in utero tobacco exposure, as identified by the Composite International Diagnostic Interview administered to mothers. Neurobehavior was assessed by the Neonatal Intensive Care Unit Network Neurobehavioral Scale. Both tools were administered between 24 and 72 hours after birth. Neurobehavioral outcomes were compared between exposed and nonexposed infants by ANOVA. The associations between neurobehavioral scores and number of cigarettes smoked were studied by linear correlation. RESULTS: During the study, 928 newborns of adolescent mothers were born, and 388 were included in the study. Of these, 23 were exposed to tobacco, and 365 neonates were not exposed. There were no differences between the groups in gestational age, birth weight, post-natal age at the exam, or time between last feeding and exam. Exposed neonates showed higher scores on arousal (p = 0.004), excitability (p = 0.003), and stress/abstinence signals (p = 0.019) and a lower score on regulation (p = 0.025). After adjusting for the type of anesthesia, mode of delivery, gender, age at neurologic exam, exam duration and time between last feeding and exam, differences in arousal and excitability remained significant. The mean number of cigarettes consumed daily was positively correlated with lethargy (p = 0.013) and inversely with attention (p = 0.043). CONCLUSIONS: Neonates exposed in utero to tobacco showed worse neurobehavioral performance between 24 and 48 hours of life.
publishDate 2011
dc.date.none.fl_str_mv 2011-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19430
10.1590/S1807-59322011000900016
url https://www.revistas.usp.br/clinics/article/view/19430
identifier_str_mv 10.1590/S1807-59322011000900016
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/19430/21493
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 66 No. 9 (2011); 1597-1603
Clinics; v. 66 n. 9 (2011); 1597-1603
Clinics; Vol. 66 Núm. 9 (2011); 1597-1603
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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