Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2007 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/0013000017z7k |
| DOI: | 10.1590/S0004-27302007000200003 |
| Texto Completo: | http://dx.doi.org/10.1590/S0004-27302007000200003 http://repositorio.unifesp.br/handle/11600/3581 |
Resumo: | Diabetic patients have a 3-fold higher risk of developing atherosclerosis and its clinical complications as compared to non-diabetic individuals. Part of the cardiovascular risk associated with diabetes is probably due to genetic determinants influencing both glucose homeostasis and the development of atherosclerosis. However, type 2 diabetes frequently coexists with other cardiovascular risk factors like arterial hypertension, central obesity and dyslipidemia. Genetic variability affecting many areas such as lipid and energy metabolisms, hypertension and haemodynamic mechanisms, blood clotting homeostasis, inflammation, and matrix turnover in the vascular wall will have an impact on the development of macrovascular complications in diabetic patients. Adiponectin is abundantly secreted by adipocytes. It plays important roles in lipid and glucose metabolisms and has direct anti-inflammatory and anti-atherogenic effects. In this review, we summarize recent data from the literature suggesting an implication of allelic variations of the adiponectin gene (ADIPOQ) in the genetic determinants of cardiovascular disease in diabetic subjects. |
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Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidencesO gene da adiponectina e o risco cardiovascular em pacientes com diabetes tipo 2: uma revisão das evidienciasGeneticsAdiponectinMacrovascular diseaseGenéticaAdiponectinaDoença macrovascularDiabetic patients have a 3-fold higher risk of developing atherosclerosis and its clinical complications as compared to non-diabetic individuals. Part of the cardiovascular risk associated with diabetes is probably due to genetic determinants influencing both glucose homeostasis and the development of atherosclerosis. However, type 2 diabetes frequently coexists with other cardiovascular risk factors like arterial hypertension, central obesity and dyslipidemia. Genetic variability affecting many areas such as lipid and energy metabolisms, hypertension and haemodynamic mechanisms, blood clotting homeostasis, inflammation, and matrix turnover in the vascular wall will have an impact on the development of macrovascular complications in diabetic patients. Adiponectin is abundantly secreted by adipocytes. It plays important roles in lipid and glucose metabolisms and has direct anti-inflammatory and anti-atherogenic effects. In this review, we summarize recent data from the literature suggesting an implication of allelic variations of the adiponectin gene (ADIPOQ) in the genetic determinants of cardiovascular disease in diabetic subjects.Os pacientes com diabetes apresentam risco três vezes maior de desenvolverem aterosclerose e suas complicações quando comparados a indivíduos sem hiperglicemia. Parte desse risco associado ao diabetes é provavelmente relacionado a determinantes genéticos que influenciam tanto a homeostase glicídica quanto o desenvolvimento da aterosclerose. Entretanto, o diabetes tipo 2 freqüentemente coexiste com outros fatores de risco cardiovascular, tais como hipertensão arterial, obesidade central e dislipidemia. A variabilidade genética interfere em várias áreas tais como o metabolismo lipídico, o metabolismo energético, hipertensão, mecanismos hemodinâmicos, mecanismos de coagulação, inflamação e na formação da matriz na parede vascular, que podem estar envolvidos nas complicações macrovasculares dos pacientes com diabetes. A adiponectina é secretada com abundância pelos adipócitos. Apresenta importante papel no metabolismo lipídico e glicídico, tendo ação direta tanto antiinflamatória quanto anti-aterogênica. Na atual revisão, nós resumimos os dados recentes da literatura que sugerem uma implicação de variantes alélicas do gene da adiponectina (ADIPOQ) que podem estar envolvidos na determinação genética da doença cardiovascular em indivíduos com diabetes.São Paulo University Laboratory of Cellular and Molecular EndocrinologyFederal University of São Paulo Laboratory of Molecular EndocrinologyFleury InstituteINSERMUniversité Paris 7UNIFESP, Laboratory of Molecular EndocrinologySciELOSociedade Brasileira de Endocrinologia e MetabologiaSão Paulo University Laboratory of Cellular and Molecular EndocrinologyUniversidade Federal de São Paulo (UNIFESP)Fleury InstituteINSERMUniversité Paris 7Ferrarezi, Daniela Andraus de FigueiredoCheurfa, NadirReis, André Fernandes [UNIFESP]Fumeron, FrédéricVelho, Gilberto [UNIFESP]2015-06-14T13:36:46Z2015-06-14T13:36:46Z2007-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion153-159application/pdfhttp://dx.doi.org/10.1590/S0004-27302007000200003Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 51, n. 2, p. 153-159, 2007.10.1590/S0004-27302007000200003S0004-27302007000200003.pdf0004-2730S0004-27302007000200003http://repositorio.unifesp.br/handle/11600/3581ark:/48912/0013000017z7kengArquivos Brasileiros de Endocrinologia & Metabologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-06T22:32:18Zoai:repositorio.unifesp.br/:11600/3581Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:02:37.933133Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences O gene da adiponectina e o risco cardiovascular em pacientes com diabetes tipo 2: uma revisão das evidiencias |
| title |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences |
| spellingShingle |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences Ferrarezi, Daniela Andraus de Figueiredo Genetics Adiponectin Macrovascular disease Genética Adiponectina Doença macrovascular Ferrarezi, Daniela Andraus de Figueiredo Genetics Adiponectin Macrovascular disease Genética Adiponectina Doença macrovascular |
| title_short |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences |
| title_full |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences |
| title_fullStr |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences |
| title_full_unstemmed |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences |
| title_sort |
Adiponectin gene and cardiovascular risk in type 2 diabetic patients: a review of evidences |
| author |
Ferrarezi, Daniela Andraus de Figueiredo |
| author_facet |
Ferrarezi, Daniela Andraus de Figueiredo Ferrarezi, Daniela Andraus de Figueiredo Cheurfa, Nadir Reis, André Fernandes [UNIFESP] Fumeron, Frédéric Velho, Gilberto [UNIFESP] Cheurfa, Nadir Reis, André Fernandes [UNIFESP] Fumeron, Frédéric Velho, Gilberto [UNIFESP] |
| author_role |
author |
| author2 |
Cheurfa, Nadir Reis, André Fernandes [UNIFESP] Fumeron, Frédéric Velho, Gilberto [UNIFESP] |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
São Paulo University Laboratory of Cellular and Molecular Endocrinology Universidade Federal de São Paulo (UNIFESP) Fleury Institute INSERM Université Paris 7 |
| dc.contributor.author.fl_str_mv |
Ferrarezi, Daniela Andraus de Figueiredo Cheurfa, Nadir Reis, André Fernandes [UNIFESP] Fumeron, Frédéric Velho, Gilberto [UNIFESP] |
| dc.subject.por.fl_str_mv |
Genetics Adiponectin Macrovascular disease Genética Adiponectina Doença macrovascular |
| topic |
Genetics Adiponectin Macrovascular disease Genética Adiponectina Doença macrovascular |
| description |
Diabetic patients have a 3-fold higher risk of developing atherosclerosis and its clinical complications as compared to non-diabetic individuals. Part of the cardiovascular risk associated with diabetes is probably due to genetic determinants influencing both glucose homeostasis and the development of atherosclerosis. However, type 2 diabetes frequently coexists with other cardiovascular risk factors like arterial hypertension, central obesity and dyslipidemia. Genetic variability affecting many areas such as lipid and energy metabolisms, hypertension and haemodynamic mechanisms, blood clotting homeostasis, inflammation, and matrix turnover in the vascular wall will have an impact on the development of macrovascular complications in diabetic patients. Adiponectin is abundantly secreted by adipocytes. It plays important roles in lipid and glucose metabolisms and has direct anti-inflammatory and anti-atherogenic effects. In this review, we summarize recent data from the literature suggesting an implication of allelic variations of the adiponectin gene (ADIPOQ) in the genetic determinants of cardiovascular disease in diabetic subjects. |
| publishDate |
2007 |
| dc.date.none.fl_str_mv |
2007-03-01 2015-06-14T13:36:46Z 2015-06-14T13:36:46Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0004-27302007000200003 Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 51, n. 2, p. 153-159, 2007. 10.1590/S0004-27302007000200003 S0004-27302007000200003.pdf 0004-2730 S0004-27302007000200003 http://repositorio.unifesp.br/handle/11600/3581 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/0013000017z7k |
| url |
http://dx.doi.org/10.1590/S0004-27302007000200003 http://repositorio.unifesp.br/handle/11600/3581 |
| identifier_str_mv |
Arquivos Brasileiros de Endocrinologia & Metabologia. Sociedade Brasileira de Endocrinologia e Metabologia, v. 51, n. 2, p. 153-159, 2007. 10.1590/S0004-27302007000200003 S0004-27302007000200003.pdf 0004-2730 S0004-27302007000200003 ark:/48912/0013000017z7k |
| dc.language.iso.fl_str_mv |
eng |
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eng |
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Arquivos Brasileiros de Endocrinologia & Metabologia |
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info:eu-repo/semantics/openAccess |
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openAccess |
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153-159 application/pdf |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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Sociedade Brasileira de Endocrinologia e Metabologia |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1822252045051101184 |
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10.1590/S0004-27302007000200003 |