Neuropeptides and oligopeptidases in schizophrenia
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/xmlui/handle/11600/62167 https://doi.org/10.1016/j.neubiorev.2019.11.024 |
Resumo: | Schizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient's livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders has been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases are able to cleave several of these neuropeptides, and their potential implication in SCZ was also demonstrated. Interestingly, these enzymes are able to play roles as modulators of neuropeptidergic systems, and they were also implicated in neurogenesis, neurite outgrowth, neuron migration, and therefore, in neurodevelopment and brain formation. Altered activity of oligopeptidases in SCZ was described only more recently, suggesting their possible utility as biomarkers for mental disorders diagnosis or treatment response. We provide here an updated and comprehensive review on neuropeptides and oligopeptidases involved in mental disorders, aiming to attract the attention of physicians to the potential of targeting this system for improving the therapy and for understanding the neurobiology underlying mental disorders as SCZ. |
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Rodriguez, Benjamín [UNIFESP]Nani, João Victor [UNIFESP]Almeida, Priscila G. C. [UNIFESP]Brietzke, ElisaLee, Richard S.Hayashi, Mirian A. F. [UNIFESP]http://lattes.cnpq.br/55593093952321472021-10-29T17:38:20Z2021-10-29T17:38:20Z2020-01Neuroscience and Biobehavioral Reviews, New York, v. 108, p. 679-693, Jan. 20201873-7528https://repositorio.unifesp.br/xmlui/handle/11600/62167https://doi.org/10.1016/j.neubiorev.2019.11.02410.1016/j.neubiorev.2019.11.024Schizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient's livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders has been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases are able to cleave several of these neuropeptides, and their potential implication in SCZ was also demonstrated. Interestingly, these enzymes are able to play roles as modulators of neuropeptidergic systems, and they were also implicated in neurogenesis, neurite outgrowth, neuron migration, and therefore, in neurodevelopment and brain formation. Altered activity of oligopeptidases in SCZ was described only more recently, suggesting their possible utility as biomarkers for mental disorders diagnosis or treatment response. We provide here an updated and comprehensive review on neuropeptides and oligopeptidases involved in mental disorders, aiming to attract the attention of physicians to the potential of targeting this system for improving the therapy and for understanding the neurobiology underlying mental disorders as SCZ.p. 679-693engPergamon PressNeuroscience & Biobehavioral ReviewsACENDEL1NeuropeptidesOligopeptidasesPOPSchizophreniaNeuropeptides and oligopeptidases in schizophreniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNew Yorkinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPEscola Paulista de Medicina (EPM)FarmacologiaOutraFarmacologiaORIGINAL1-s2.0-S0149763419303975-main.pdf1-s2.0-S0149763419303975-main.pdfapplication/pdf954711${dspace.ui.url}/bitstream/11600/62167/1/1-s2.0-S0149763419303975-main.pdf62732f2e4ab9ac6add5b28b6a692e77dMD51open 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dc.title.pt_BR.fl_str_mv |
Neuropeptides and oligopeptidases in schizophrenia |
title |
Neuropeptides and oligopeptidases in schizophrenia |
spellingShingle |
Neuropeptides and oligopeptidases in schizophrenia Rodriguez, Benjamín [UNIFESP] ACE NDEL1 Neuropeptides Oligopeptidases POP Schizophrenia |
title_short |
Neuropeptides and oligopeptidases in schizophrenia |
title_full |
Neuropeptides and oligopeptidases in schizophrenia |
title_fullStr |
Neuropeptides and oligopeptidases in schizophrenia |
title_full_unstemmed |
Neuropeptides and oligopeptidases in schizophrenia |
title_sort |
Neuropeptides and oligopeptidases in schizophrenia |
author |
Rodriguez, Benjamín [UNIFESP] |
author_facet |
Rodriguez, Benjamín [UNIFESP] Nani, João Victor [UNIFESP] Almeida, Priscila G. C. [UNIFESP] Brietzke, Elisa Lee, Richard S. Hayashi, Mirian A. F. [UNIFESP] |
author_role |
author |
author2 |
Nani, João Victor [UNIFESP] Almeida, Priscila G. C. [UNIFESP] Brietzke, Elisa Lee, Richard S. Hayashi, Mirian A. F. [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.authorLattes.pt_BR.fl_str_mv |
http://lattes.cnpq.br/5559309395232147 |
dc.contributor.author.fl_str_mv |
Rodriguez, Benjamín [UNIFESP] Nani, João Victor [UNIFESP] Almeida, Priscila G. C. [UNIFESP] Brietzke, Elisa Lee, Richard S. Hayashi, Mirian A. F. [UNIFESP] |
dc.subject.por.fl_str_mv |
ACE NDEL1 Neuropeptides Oligopeptidases POP Schizophrenia |
topic |
ACE NDEL1 Neuropeptides Oligopeptidases POP Schizophrenia |
description |
Schizophrenia (SCZ) is a complex psychiatric disorder with severe impact on patient's livelihood. In the last years, the importance of neuropeptides in SCZ and other CNS disorders has been recognized, mainly due to their ability to modulate the signaling of classical monoaminergic neurotransmitters as dopamine. In addition, a class of enzymes coined as oligopeptidases are able to cleave several of these neuropeptides, and their potential implication in SCZ was also demonstrated. Interestingly, these enzymes are able to play roles as modulators of neuropeptidergic systems, and they were also implicated in neurogenesis, neurite outgrowth, neuron migration, and therefore, in neurodevelopment and brain formation. Altered activity of oligopeptidases in SCZ was described only more recently, suggesting their possible utility as biomarkers for mental disorders diagnosis or treatment response. We provide here an updated and comprehensive review on neuropeptides and oligopeptidases involved in mental disorders, aiming to attract the attention of physicians to the potential of targeting this system for improving the therapy and for understanding the neurobiology underlying mental disorders as SCZ. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-01 |
dc.date.accessioned.fl_str_mv |
2021-10-29T17:38:20Z |
dc.date.available.fl_str_mv |
2021-10-29T17:38:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Neuroscience and Biobehavioral Reviews, New York, v. 108, p. 679-693, Jan. 2020 |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/xmlui/handle/11600/62167 https://doi.org/10.1016/j.neubiorev.2019.11.024 |
dc.identifier.issn.none.fl_str_mv |
1873-7528 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.neubiorev.2019.11.024 |
identifier_str_mv |
Neuroscience and Biobehavioral Reviews, New York, v. 108, p. 679-693, Jan. 2020 1873-7528 10.1016/j.neubiorev.2019.11.024 |
url |
https://repositorio.unifesp.br/xmlui/handle/11600/62167 https://doi.org/10.1016/j.neubiorev.2019.11.024 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Neuroscience & Biobehavioral Reviews |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
p. 679-693 |
dc.coverage.none.fl_str_mv |
New York |
dc.publisher.none.fl_str_mv |
Pergamon Press |
publisher.none.fl_str_mv |
Pergamon Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
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repository.name.fl_str_mv |
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repository.mail.fl_str_mv |
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